Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Dokumenter

  • Article

    Forlagets udgivne version, 1,61 MB, PDF-dokument

Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy. If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue. The term reserve respiratory capacity or spare respiratory capacity is used to describe the amount of extra ATP that can be produced by oxidative phosphorylation in case of a sudden increase in energy demand. Depletion of the reserve respiratory capacity has been related to a range of pathologies affecting high energy requiring tissues. During aging of an organism, and as a result of mitochondrial dysfunctions, the efficiency of oxidative phosphorylation declines. Based on examples from the energy requiring tissues such as brain, heart, and skeletal muscle, we propose that the age-related decline of oxidative phosphorylation decreases the reserve respiratory capacity of the affected tissue, sensitizes the cells to surges in ATP demand, and increases the risk of resulting pathologies.
Bidragets oversatte titelEr der en forbindelse mellem mitokondriel reserve respiratorisk kapacitet og aldring?
OriginalsprogEngelsk
TidsskriftJournal of Aging Research
Vol/bind2012
Sider (fra-til)192503
Antal sider9
ISSN2090-2204
DOI
StatusUdgivet - 2012

Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk


Ingen data tilgængelig

ID: 38379152