Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men
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Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men. / Janus, Charlotte; Vistisen, Dorte; Amadid, Hanan; Witte, Daniel R; Lauritzen, Torsten; Brage, Søren; Bjerregaard, Anne-Louise; Hansen, Torben; Holst, Jens Juul; Jørgensen, Marit Eika; Pedersen, Oluf; Færch, Kristine; Torekov, Signe.
I: Endocrine Connections, Bind 8, Nr. 12, 2019, s. 1607–1617.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Habitual activity associates with lower fasting and greater glucose-induced GLP-1 response in men
AU - Janus, Charlotte
AU - Vistisen, Dorte
AU - Amadid, Hanan
AU - Witte, Daniel R
AU - Lauritzen, Torsten
AU - Brage, Søren
AU - Bjerregaard, Anne-Louise
AU - Hansen, Torben
AU - Holst, Jens Juul
AU - Jørgensen, Marit Eika
AU - Pedersen, Oluf
AU - Færch, Kristine
AU - Torekov, Signe
PY - 2019
Y1 - 2019
N2 - RATIONALE: The hormone glucagon-like peptide-1 (GLP-1) decreases blood glucose and appetite. Greater physical activity (PA) is associated with lower incidence of type 2 diabetes. While acute exercise may increase glucose-induced response of GLP-1, it is unknown how habitual PA affects GLP-1 secretion. We hypothesised that habitual PA associates with greater glucose-induced GLP-1 responses in overweight individuals.METHODS: Cross-sectional analysis of habitual PA levels and GLP-1 concentrations in 1326 individuals (mean (SD) age 66 (7) years, BMI 27.1 (4.5) kg/m2) from the ADDITION-PRO cohort. Fasting and oral glucose-stimulated GLP-1 responseswere measured using validated radioimmunoassay. PA was measured using 7-days combined accelerometry and heart rate monitoring. From this, energy expenditure (PAEE;kJ/kg/day) and fractions of time spent in activity intensities (hours/day) were calculated. Cardiorespiratory fitness (CRF;ml O2/kg/min) was calculated using step tests. Age-, BMI- and insulin sensitivity-adjusted associations between PA and GLP-1, stratified by sex, were evaluated by linear regression analysis.RESULTS: In 703 men, fasting GLP-1 concentrations were 20% lower (95%CI: -33;-3%, P=0.02) for every hour of moderate-intensity PA performed. Higher CRF and PAEE were associated with 1-2% lower fasting GLP-1 (P=0.01). For every hour moderate-intensity PA, the glucose-stimulated GLP-1 response was 16% greater at peak 30 min (1;33%, PrAUC0-30=0.04) and 20% greater at full response (3;40%, PrAUC0-120=0.02). No associations were found in women who performed PA 22 min/day versus 32 min/day for men.CONCLUSION: Moderate-intensity PA is associated with lower fasting and greater glucose-induced GLP-1 responses in overweight men, possibly contributing to improved glucose and appetite regulation with increased habitual PA.
AB - RATIONALE: The hormone glucagon-like peptide-1 (GLP-1) decreases blood glucose and appetite. Greater physical activity (PA) is associated with lower incidence of type 2 diabetes. While acute exercise may increase glucose-induced response of GLP-1, it is unknown how habitual PA affects GLP-1 secretion. We hypothesised that habitual PA associates with greater glucose-induced GLP-1 responses in overweight individuals.METHODS: Cross-sectional analysis of habitual PA levels and GLP-1 concentrations in 1326 individuals (mean (SD) age 66 (7) years, BMI 27.1 (4.5) kg/m2) from the ADDITION-PRO cohort. Fasting and oral glucose-stimulated GLP-1 responseswere measured using validated radioimmunoassay. PA was measured using 7-days combined accelerometry and heart rate monitoring. From this, energy expenditure (PAEE;kJ/kg/day) and fractions of time spent in activity intensities (hours/day) were calculated. Cardiorespiratory fitness (CRF;ml O2/kg/min) was calculated using step tests. Age-, BMI- and insulin sensitivity-adjusted associations between PA and GLP-1, stratified by sex, were evaluated by linear regression analysis.RESULTS: In 703 men, fasting GLP-1 concentrations were 20% lower (95%CI: -33;-3%, P=0.02) for every hour of moderate-intensity PA performed. Higher CRF and PAEE were associated with 1-2% lower fasting GLP-1 (P=0.01). For every hour moderate-intensity PA, the glucose-stimulated GLP-1 response was 16% greater at peak 30 min (1;33%, PrAUC0-30=0.04) and 20% greater at full response (3;40%, PrAUC0-120=0.02). No associations were found in women who performed PA 22 min/day versus 32 min/day for men.CONCLUSION: Moderate-intensity PA is associated with lower fasting and greater glucose-induced GLP-1 responses in overweight men, possibly contributing to improved glucose and appetite regulation with increased habitual PA.
U2 - 10.1530/EC-19-0408
DO - 10.1530/EC-19-0408
M3 - Journal article
C2 - 31804964
VL - 8
SP - 1607
EP - 1617
JO - Endocrine Connections
JF - Endocrine Connections
SN - 2049-3614
IS - 12
ER -
ID: 231716183