Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

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Standard

Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor. / Ahorukomeye, Peter; Disotuar, Maria M; Gajewiak, Joanna; Karanth, Santhosh; Watkins, Maren; Robinson, Samuel D; Flórez Salcedo, Paula; Smith, Nicholas A; Smith, Brian J; Schlegel, Amnon; Forbes, Briony E; Olivera, Baldomero; Hung-Chieh Chou, Danny; Safavi-Hemami, Helena.

I: eLife, Bind 8, e41574, 2019.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ahorukomeye, P, Disotuar, MM, Gajewiak, J, Karanth, S, Watkins, M, Robinson, SD, Flórez Salcedo, P, Smith, NA, Smith, BJ, Schlegel, A, Forbes, BE, Olivera, B, Hung-Chieh Chou, D & Safavi-Hemami, H 2019, 'Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor', eLife, bind 8, e41574. https://doi.org/10.7554/eLife.41574

APA

Ahorukomeye, P., Disotuar, M. M., Gajewiak, J., Karanth, S., Watkins, M., Robinson, S. D., Flórez Salcedo, P., Smith, N. A., Smith, B. J., Schlegel, A., Forbes, B. E., Olivera, B., Hung-Chieh Chou, D., & Safavi-Hemami, H. (2019). Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor. eLife, 8, [e41574]. https://doi.org/10.7554/eLife.41574

Vancouver

Ahorukomeye P, Disotuar MM, Gajewiak J, Karanth S, Watkins M, Robinson SD o.a. Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor. eLife. 2019;8. e41574. https://doi.org/10.7554/eLife.41574

Author

Ahorukomeye, Peter ; Disotuar, Maria M ; Gajewiak, Joanna ; Karanth, Santhosh ; Watkins, Maren ; Robinson, Samuel D ; Flórez Salcedo, Paula ; Smith, Nicholas A ; Smith, Brian J ; Schlegel, Amnon ; Forbes, Briony E ; Olivera, Baldomero ; Hung-Chieh Chou, Danny ; Safavi-Hemami, Helena. / Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor. I: eLife. 2019 ; Bind 8.

Bibtex

@article{6ceb10e5ee0e44a0a2c4aa13d8eae291,

title = "Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor",

abstract = "The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to induce hypoglycemic shock in its prey. We recently showed that this venom insulin, Con-Ins G1, has unique characteristics relevant to the design of new insulin therapeutics. Here, we show that fish-hunting cone snails provide a rich source of minimized ligands of the vertebrate insulin receptor. Insulins from C. geographus, Conus tulipa and Conus kinoshitai exhibit diverse sequences, yet all bind to and activate the human insulin receptor. Molecular dynamics reveal unique modes of action that are distinct from any other insulins known in nature. When tested in zebrafish and mice, venom insulins significantly lower blood glucose in the streptozotocin-induced model of diabetes. Our findings suggest that cone snails have evolved diverse strategies to activate the vertebrate insulin receptor and provide unique insight into the design of novel drugs for the treatment of diabetes.",

author = "Peter Ahorukomeye and Disotuar, {Maria M} and Joanna Gajewiak and Santhosh Karanth and Maren Watkins and Robinson, {Samuel D} and {Fl{\'o}rez Salcedo}, Paula and Smith, {Nicholas A} and Smith, {Brian J} and Amnon Schlegel and Forbes, {Briony E} and Baldomero Olivera and {Hung-Chieh Chou}, Danny and Helena Safavi-Hemami",

note = "{\textcopyright} 2019, Ahorukomeye et al.",

year = "2019",

doi = "10.7554/eLife.41574",

language = "English",

volume = "8",

journal = "eLife",

issn = "2050-084X",

publisher = "eLife Sciences Publications Ltd.",

}

RIS

TY - JOUR

T1 - Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

AU - Ahorukomeye, Peter

AU - Disotuar, Maria M

AU - Gajewiak, Joanna

AU - Karanth, Santhosh

AU - Watkins, Maren

AU - Robinson, Samuel D

AU - Flórez Salcedo, Paula

AU - Smith, Nicholas A

AU - Smith, Brian J

AU - Schlegel, Amnon

AU - Forbes, Briony E

AU - Olivera, Baldomero

AU - Hung-Chieh Chou, Danny

AU - Safavi-Hemami, Helena

PY - 2019

Y1 - 2019

N2 - The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to induce hypoglycemic shock in its prey. We recently showed that this venom insulin, Con-Ins G1, has unique characteristics relevant to the design of new insulin therapeutics. Here, we show that fish-hunting cone snails provide a rich source of minimized ligands of the vertebrate insulin receptor. Insulins from C. geographus, Conus tulipa and Conus kinoshitai exhibit diverse sequences, yet all bind to and activate the human insulin receptor. Molecular dynamics reveal unique modes of action that are distinct from any other insulins known in nature. When tested in zebrafish and mice, venom insulins significantly lower blood glucose in the streptozotocin-induced model of diabetes. Our findings suggest that cone snails have evolved diverse strategies to activate the vertebrate insulin receptor and provide unique insight into the design of novel drugs for the treatment of diabetes.

AB - The fish-hunting marine cone snail Conus geographus uses a specialized venom insulin to induce hypoglycemic shock in its prey. We recently showed that this venom insulin, Con-Ins G1, has unique characteristics relevant to the design of new insulin therapeutics. Here, we show that fish-hunting cone snails provide a rich source of minimized ligands of the vertebrate insulin receptor. Insulins from C. geographus, Conus tulipa and Conus kinoshitai exhibit diverse sequences, yet all bind to and activate the human insulin receptor. Molecular dynamics reveal unique modes of action that are distinct from any other insulins known in nature. When tested in zebrafish and mice, venom insulins significantly lower blood glucose in the streptozotocin-induced model of diabetes. Our findings suggest that cone snails have evolved diverse strategies to activate the vertebrate insulin receptor and provide unique insight into the design of novel drugs for the treatment of diabetes.

U2 - 10.7554/eLife.41574

DO - 10.7554/eLife.41574

M3 - Journal article

C2 - 30747102

VL - 8

JO - eLife

JF - eLife

SN - 2050-084X

M1 - e41574

ER -

ID: 232822888