Determinants of neurodevelopment in early childhood - results from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010 ) Mother-Child Cohort
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Determinants of neurodevelopment in early childhood - results from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010 ) Mother-Child Cohort. / Bjarnadóttir, Elín; Stokholm, Jakob; Chawes, Bo; Thorsen, Jonathan; Mora-Jensen, Anna Rosa Cecilie; Deleuran, Maja; Bønnelykke, Klaus; Lauritzen, Lotte; Bisgaard, Hans.
I: Acta Paediatrica, Bind 108, Nr. 9, 2019, s. 1632-1641.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Determinants of neurodevelopment in early childhood - results from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2010 ) Mother-Child Cohort
AU - Bjarnadóttir, Elín
AU - Stokholm, Jakob
AU - Chawes, Bo
AU - Thorsen, Jonathan
AU - Mora-Jensen, Anna Rosa Cecilie
AU - Deleuran, Maja
AU - Bønnelykke, Klaus
AU - Lauritzen, Lotte
AU - Bisgaard, Hans
N1 - CURIS 2019 NEXS 106 This article is protected by copyright. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Aim: The objective of this study was to identify possible pre- and postnatal factors influencing neurodevelopment of the young child.Methods: We used data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother-child cohort, but excluded those with a neurological diagnosis, born <37 weeks of gestation and birth weights <2500g, resulting in 650 children analyzed. Neurodevelopment was assessed as age of achievement of early milestones, language scores at 1 and 2 years and cognitive score at 2 ½ years of age.Results: Neurodevelopmental scores were not associated with breastfeeding, persistent wheeze, eczema, and number of sick days (p>0.05 in all tests). Early age at milestone achievement was associated with male sex (p=0.05), lower maternal age (p=0.02), higher gestational age (p<0.001) and paternity leave (p=0.01). A higher 1-year language score was associated with female sex (p=0.02) and maternal smoking during pregnancy (p=0.01) and a higher 2-year language score with female sex (p<0.001) and being first born (p=0.01). A higher cognitive score was associated with female sex (p=0.02).Conclusion: Neurodevelopmental scores were unrelated to breast-feeding, persistent wheeze, eczema, and number of sick days.
AB - Aim: The objective of this study was to identify possible pre- and postnatal factors influencing neurodevelopment of the young child.Methods: We used data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) mother-child cohort, but excluded those with a neurological diagnosis, born <37 weeks of gestation and birth weights <2500g, resulting in 650 children analyzed. Neurodevelopment was assessed as age of achievement of early milestones, language scores at 1 and 2 years and cognitive score at 2 ½ years of age.Results: Neurodevelopmental scores were not associated with breastfeeding, persistent wheeze, eczema, and number of sick days (p>0.05 in all tests). Early age at milestone achievement was associated with male sex (p=0.05), lower maternal age (p=0.02), higher gestational age (p<0.001) and paternity leave (p=0.01). A higher 1-year language score was associated with female sex (p=0.02) and maternal smoking during pregnancy (p=0.01) and a higher 2-year language score with female sex (p<0.001) and being first born (p=0.01). A higher cognitive score was associated with female sex (p=0.02).Conclusion: Neurodevelopmental scores were unrelated to breast-feeding, persistent wheeze, eczema, and number of sick days.
KW - Faculty of Science
KW - Cognitive development
KW - Language development
KW - Motor development
KW - Neurological development
U2 - 10.1111/apa.14753
DO - 10.1111/apa.14753
M3 - Journal article
C2 - 30748036
VL - 108
SP - 1632
EP - 1641
JO - Acta Paediatrica
JF - Acta Paediatrica
SN - 0803-5253
IS - 9
ER -
ID: 213319895