Calpain 3 is important for muscle regeneration: evidence from patients with limb girdle muscular dystrophies

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

  • Simon Hauerslev
  • Marie-Louise Sveen
  • Morten Duno
  • Corrado Angelini
  • Vissing, John
  • Thomas O Krag
Limb girdle muscular dystrophy (LGMD) type 2A is caused by mutations in the CAPN3 gene and complete lack of functional calpain 3 leads to the most severe muscle wasting. Calpain 3 is suggested to be involved in maturation of contractile elements after muscle degeneration. The aim of this study was to investigate how mutations in the four functional domains of calpain 3 affect muscle regeneration.
TidsskriftB M C Musculoskeletal Disorders
Sider (fra-til)43-53
Antal sider11
StatusUdgivet - 2012

ID: 48603950