Xanthones from the twigs of Garcinia oblongifolia and their antidiabetic activity
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Three new xanthones, oblongixanthone F-H (1-3), along with eight known xanthones (4-11), were isolated from an EtOAc extract of the twigs of Garcinia oblongifolia. Their structures were elucidated by spectroscopic analysis including 1D- and 2D-NMR spectroscopy and mass spectrometry. The antidiabetic effects of all isolated compounds were evaluated by in vitro α-glucosidase and PTP1B inhibition assays. Compound 11 was the most active compound, and inhibited α-glucosidase and PTP1B with IC50 values of 1.7 ± 0.5 and 14.1 ± 3.5 μM, respectively
Originalsprog | Engelsk |
---|---|
Tidsskrift | Fitoterapia |
Vol/bind | 118 |
Sider (fra-til) | 126-131 |
ISSN | 1971-551X |
DOI | |
Status | Udgivet - 2017 |
ID: 174043664