What are the DNA lesions underlying formaldehyde toxicity?
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Formaldehyde is a highly reactive organic compound. Humans can be exposed to exogenous sources of formaldehyde, but formaldehyde is also produced endogenously as a byproduct of cellular metabolism. Because formaldehyde can react with DNA, it is considered a major endogenous source of DNA damage. However, the nature of the lesions underlying formaldehyde toxicity in cells remains vastly unknown. Here, we review the current knowledge of the different types of nucleic acid lesions that are induced by formaldehyde and describe the repair pathways known to counteract formaldehyde toxicity. Taking this knowledge together, we discuss and speculate on the predominant lesions generated by formaldehyde, which underly its natural toxicity.
Originalsprog | Engelsk |
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Artikelnummer | 103667 |
Tidsskrift | DNA Repair |
Vol/bind | 138 |
Antal sider | 14 |
ISSN | 1568-7864 |
DOI | |
Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:
We thank Ivan Valle Rosado and members of the Duxin laboratory for valuable feedback on the manuscript. The Novo Nordisk Foundation Center for Protein Research is supported financially by the Novo Nordisk Foundation (grant agreement NNF14CC0001). This work has received funding from The Danish Cancer Society (grant agreement R302-A17610). B.B is supported by EMBO (grant agreement ALTF 1149-2020). All figures were created using BioRender.com.
Publisher Copyright:
© 2024
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