Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels. / Engelbrechtsen, Line; Iepsen, Eva Pers Winning; Galijatovic, Ehm Astrid Andersson; Mahendran, Yuvaraj; Lundgren, Julie Rehné; Jonsson, Anna Elisabet; Madsbad, Sten; Holst, Jens Juul; Vestergaard, Henrik; Hansen, Torben; Torekov, Signe Sørensen.

I: Metabolomics, Bind 12, Nr. 12, 181, 12.2016, s. 1-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Engelbrechtsen, L, Iepsen, EPW, Galijatovic, EAA, Mahendran, Y, Lundgren, JR, Jonsson, AE, Madsbad, S, Holst, JJ, Vestergaard, H, Hansen, T & Torekov, SS 2016, 'Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels', Metabolomics, bind 12, nr. 12, 181, s. 1-9. https://doi.org/10.1007/s11306-016-1128-0

APA

Engelbrechtsen, L., Iepsen, E. P. W., Galijatovic, E. A. A., Mahendran, Y., Lundgren, J. R., Jonsson, A. E., Madsbad, S., Holst, J. J., Vestergaard, H., Hansen, T., & Torekov, S. S. (2016). Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels. Metabolomics, 12(12), 1-9. [181]. https://doi.org/10.1007/s11306-016-1128-0

Vancouver

Engelbrechtsen L, Iepsen EPW, Galijatovic EAA, Mahendran Y, Lundgren JR, Jonsson AE o.a. Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels. Metabolomics. 2016 dec;12(12):1-9. 181. https://doi.org/10.1007/s11306-016-1128-0

Author

Engelbrechtsen, Line ; Iepsen, Eva Pers Winning ; Galijatovic, Ehm Astrid Andersson ; Mahendran, Yuvaraj ; Lundgren, Julie Rehné ; Jonsson, Anna Elisabet ; Madsbad, Sten ; Holst, Jens Juul ; Vestergaard, Henrik ; Hansen, Torben ; Torekov, Signe Sørensen. / Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels. I: Metabolomics. 2016 ; Bind 12, Nr. 12. s. 1-9.

Bibtex

@article{dd7ae79ed589475c9b4f462e55febd14,
title = "Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels",
abstract = "Introduction Increased levels of circulating branched chain amino acids (BCAAs), as well as phenylalanine, and tyrosine have been suggested to be involved in the pathogenesis of insulin resistance and type 2 diabetes. However, it is unknown how these metabolites are affected by weight loss, and during weight-maintaining treatment with glucagon-like peptide-1 receptor agonist (GLP-1 RA). Objective We aimed to characterize changes in metabolites related to protein turnover and glycolysis after a weight loss intervention followed by long term weight maintenance with/without GLP-1 RA. Methods Fifty-eight obese individuals underwent a diet-induced 12 % body weight loss during 8 weeks. Participants were randomized to weight maintenance with or without administration of the GLP-1 RA liraglutide (1.2 mg/day) for 52 weeks. Metabolomic profiling by high-throughput proton nuclear magnetic resonance spectroscopy was used for quantification of metabolites. Results The weight loss was maintained in both groups and was associated with 9–20 % decreases in plasma concentrations of alanine, phenylalanine, histidine, tyrosine and the BCAAs leucine, isoleucine and valine (p < 0.05). Plasma citrate levels increased during weight loss (p = 5.2 × 10−15) and showed inverse correlation with insulin resistance measured by HOMA–IR levels (r = −0.318, p = 0.025). Valine concentrations were lower in the control group compared to the GLP-1RA group during weight maintenance (p = 0.005). Conclusion Weight loss is associated with marked changes in plasma concentrations of eight amino acids and glycolysis-related metabolites. Levels of the suggested type 2 diabetes risk markers (BCAAs) remain low during long-term weight maintenance. ",
author = "Line Engelbrechtsen and Iepsen, {Eva Pers Winning} and Galijatovic, {Ehm Astrid Andersson} and Yuvaraj Mahendran and Lundgren, {Julie Rehn{\'e}} and Jonsson, {Anna Elisabet} and Sten Madsbad and Holst, {Jens Juul} and Henrik Vestergaard and Torben Hansen and Torekov, {Signe S{\o}rensen}",
year = "2016",
month = dec,
doi = "10.1007/s11306-016-1128-0",
language = "English",
volume = "12",
pages = "1--9",
journal = "Metabolomics",
issn = "1573-3882",
publisher = "Springer",
number = "12",

}

RIS

TY - JOUR

T1 - Weight loss and weight maintenance obtained with or without GLP-1 analogue treatment decrease branched chain amino acid levels

AU - Engelbrechtsen, Line

AU - Iepsen, Eva Pers Winning

AU - Galijatovic, Ehm Astrid Andersson

AU - Mahendran, Yuvaraj

AU - Lundgren, Julie Rehné

AU - Jonsson, Anna Elisabet

AU - Madsbad, Sten

AU - Holst, Jens Juul

AU - Vestergaard, Henrik

AU - Hansen, Torben

AU - Torekov, Signe Sørensen

PY - 2016/12

Y1 - 2016/12

N2 - Introduction Increased levels of circulating branched chain amino acids (BCAAs), as well as phenylalanine, and tyrosine have been suggested to be involved in the pathogenesis of insulin resistance and type 2 diabetes. However, it is unknown how these metabolites are affected by weight loss, and during weight-maintaining treatment with glucagon-like peptide-1 receptor agonist (GLP-1 RA). Objective We aimed to characterize changes in metabolites related to protein turnover and glycolysis after a weight loss intervention followed by long term weight maintenance with/without GLP-1 RA. Methods Fifty-eight obese individuals underwent a diet-induced 12 % body weight loss during 8 weeks. Participants were randomized to weight maintenance with or without administration of the GLP-1 RA liraglutide (1.2 mg/day) for 52 weeks. Metabolomic profiling by high-throughput proton nuclear magnetic resonance spectroscopy was used for quantification of metabolites. Results The weight loss was maintained in both groups and was associated with 9–20 % decreases in plasma concentrations of alanine, phenylalanine, histidine, tyrosine and the BCAAs leucine, isoleucine and valine (p < 0.05). Plasma citrate levels increased during weight loss (p = 5.2 × 10−15) and showed inverse correlation with insulin resistance measured by HOMA–IR levels (r = −0.318, p = 0.025). Valine concentrations were lower in the control group compared to the GLP-1RA group during weight maintenance (p = 0.005). Conclusion Weight loss is associated with marked changes in plasma concentrations of eight amino acids and glycolysis-related metabolites. Levels of the suggested type 2 diabetes risk markers (BCAAs) remain low during long-term weight maintenance.

AB - Introduction Increased levels of circulating branched chain amino acids (BCAAs), as well as phenylalanine, and tyrosine have been suggested to be involved in the pathogenesis of insulin resistance and type 2 diabetes. However, it is unknown how these metabolites are affected by weight loss, and during weight-maintaining treatment with glucagon-like peptide-1 receptor agonist (GLP-1 RA). Objective We aimed to characterize changes in metabolites related to protein turnover and glycolysis after a weight loss intervention followed by long term weight maintenance with/without GLP-1 RA. Methods Fifty-eight obese individuals underwent a diet-induced 12 % body weight loss during 8 weeks. Participants were randomized to weight maintenance with or without administration of the GLP-1 RA liraglutide (1.2 mg/day) for 52 weeks. Metabolomic profiling by high-throughput proton nuclear magnetic resonance spectroscopy was used for quantification of metabolites. Results The weight loss was maintained in both groups and was associated with 9–20 % decreases in plasma concentrations of alanine, phenylalanine, histidine, tyrosine and the BCAAs leucine, isoleucine and valine (p < 0.05). Plasma citrate levels increased during weight loss (p = 5.2 × 10−15) and showed inverse correlation with insulin resistance measured by HOMA–IR levels (r = −0.318, p = 0.025). Valine concentrations were lower in the control group compared to the GLP-1RA group during weight maintenance (p = 0.005). Conclusion Weight loss is associated with marked changes in plasma concentrations of eight amino acids and glycolysis-related metabolites. Levels of the suggested type 2 diabetes risk markers (BCAAs) remain low during long-term weight maintenance.

U2 - 10.1007/s11306-016-1128-0

DO - 10.1007/s11306-016-1128-0

M3 - Journal article

VL - 12

SP - 1

EP - 9

JO - Metabolomics

JF - Metabolomics

SN - 1573-3882

IS - 12

M1 - 181

ER -

ID: 169159035