Use of register‐ and survey‐based measures of anxiety in a population‐based Danish cohort
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Use of register‐ and survey‐based measures of anxiety in a population‐based Danish cohort. / Osler, Merete; Rozing, Maarten Pieter; Wium‐Andersen, Ida Kim; Wium‐Andersen, Marie Kim; Dantoft, Thomas Meinertz; Fink, Per; Jørgensen, Martin Balslev; Jørgensen, Terese Sara Høj.
I: Acta Psychiatrica Scandinavica, Bind 144, Nr. 5, 2021, s. 501-509.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Use of register‐ and survey‐based measures of anxiety in a population‐based Danish cohort
AU - Osler, Merete
AU - Rozing, Maarten Pieter
AU - Wium‐Andersen, Ida Kim
AU - Wium‐Andersen, Marie Kim
AU - Dantoft, Thomas Meinertz
AU - Fink, Per
AU - Jørgensen, Martin Balslev
AU - Jørgensen, Terese Sara Høj
PY - 2021
Y1 - 2021
N2 - ObjectiveWe explored the comparability of anxiety measures from register- and survey-based data including analyses of prevalence and associations with selected psychiatric and somatic diseases.MethodsWe measured anxiety using Danish registers (hospital diagnosis and anxiolytic drug prescriptions), self-reports, symptom checklist (SCL) scores, and a clinical interview in 7493 adults with mean age 52 (SD 13.3) years who participated in a health survey between 2012 and 2015. We estimated the prevalence of anxiety, agreement between different measures and performed quantitative bias analysis.ResultsThe lifetime prevalence of hospital diagnosed anxiety, anxiolytic drug prescriptions, and self-reported anxiety were 4.4%, 6.2%, and 5.1%, respectively, after adjusting for selective participation. The agreement between the different anxiety measures was low. Thus, 25% with an anxiety diagnosis and 20% with anxiolytic drug prescriptions also had a high SCL score. Anxiolytic drugs were the only measure significantly associated with higher odds of heart disease. Hospital diagnosis and self-reported anxiety were associated with depression with odds ratio (OR) above 15, whereas anxiolytic drug prescriptions were less strongly associated (OR = 2.2(95% confidence interval: 1.26–3.91)). The risk estimates attenuated considerably when correcting for measurement error, whereas the ORs became slightly higher when the selective participation in the survey was accounted for.ConclusionAnxiety diagnosed in hospitals and self-reported anxiety showed low level of agreement but provide comparable results regarding frequency measures and associations with disease outcomes.
AB - ObjectiveWe explored the comparability of anxiety measures from register- and survey-based data including analyses of prevalence and associations with selected psychiatric and somatic diseases.MethodsWe measured anxiety using Danish registers (hospital diagnosis and anxiolytic drug prescriptions), self-reports, symptom checklist (SCL) scores, and a clinical interview in 7493 adults with mean age 52 (SD 13.3) years who participated in a health survey between 2012 and 2015. We estimated the prevalence of anxiety, agreement between different measures and performed quantitative bias analysis.ResultsThe lifetime prevalence of hospital diagnosed anxiety, anxiolytic drug prescriptions, and self-reported anxiety were 4.4%, 6.2%, and 5.1%, respectively, after adjusting for selective participation. The agreement between the different anxiety measures was low. Thus, 25% with an anxiety diagnosis and 20% with anxiolytic drug prescriptions also had a high SCL score. Anxiolytic drugs were the only measure significantly associated with higher odds of heart disease. Hospital diagnosis and self-reported anxiety were associated with depression with odds ratio (OR) above 15, whereas anxiolytic drug prescriptions were less strongly associated (OR = 2.2(95% confidence interval: 1.26–3.91)). The risk estimates attenuated considerably when correcting for measurement error, whereas the ORs became slightly higher when the selective participation in the survey was accounted for.ConclusionAnxiety diagnosed in hospitals and self-reported anxiety showed low level of agreement but provide comparable results regarding frequency measures and associations with disease outcomes.
U2 - 10.1111/acps.13339
DO - 10.1111/acps.13339
M3 - Journal article
C2 - 34139021
VL - 144
SP - 501
EP - 509
JO - Acta Psychiatrica Scandinavica. Supplementum
JF - Acta Psychiatrica Scandinavica. Supplementum
SN - 0065-1591
IS - 5
ER -
ID: 273705598