Urinary phthalate metabolites and depression in an elderly population: National Health and Nutrition Examination Survey 2005-2012

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Urinary phthalate metabolites and depression in an elderly population : National Health and Nutrition Examination Survey 2005-2012. / Kim, Kyoung-Nam; Choi, Yoon-Hyeong; Lim, Youn-Hee; Hong, Yun-Chul.

I: Environmental Research, Bind 145, 2016, s. 61-67.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Kim, K-N, Choi, Y-H, Lim, Y-H & Hong, Y-C 2016, 'Urinary phthalate metabolites and depression in an elderly population: National Health and Nutrition Examination Survey 2005-2012', Environmental Research, bind 145, s. 61-67. https://doi.org/10.1016/j.envres.2015.11.021

APA

Kim, K-N., Choi, Y-H., Lim, Y-H., & Hong, Y-C. (2016). Urinary phthalate metabolites and depression in an elderly population: National Health and Nutrition Examination Survey 2005-2012. Environmental Research, 145, 61-67. https://doi.org/10.1016/j.envres.2015.11.021

Vancouver

Kim K-N, Choi Y-H, Lim Y-H, Hong Y-C. Urinary phthalate metabolites and depression in an elderly population: National Health and Nutrition Examination Survey 2005-2012. Environmental Research. 2016;145:61-67. https://doi.org/10.1016/j.envres.2015.11.021

Author

Kim, Kyoung-Nam ; Choi, Yoon-Hyeong ; Lim, Youn-Hee ; Hong, Yun-Chul. / Urinary phthalate metabolites and depression in an elderly population : National Health and Nutrition Examination Survey 2005-2012. I: Environmental Research. 2016 ; Bind 145. s. 61-67.

Bibtex

@article{b33394b8e7a942d2ac206a98ad18c098,
title = "Urinary phthalate metabolites and depression in an elderly population: National Health and Nutrition Examination Survey 2005-2012",
abstract = "Previous animal studies have demonstrated that phthalate exposure is associated with depression-like behaviors. However, no human study has explored this relationship. We explored the association between urinary phthalate metabolite concentrations and depression in a nationally representative sample of the U.S. elderly population. We analyzed 2030 participants aged 60 years or older with available data on phthalates and depression from the 2005 to 2012 National Health and Nutrition Examination Survey (NHANES). We selected 10 urinary phthalate metabolites with a weighted detection rate >60%. Depression was defined as a 9-item Patient Health Questionnaire score ≥10. The models were adjusted for age, sex, race/ethnicity, education level, income-to-poverty ratio, health insurance coverage, marital status, smoking status, alcohol consumption, moderate physical activity, body mass index, comorbidity status, NHANEs cycle, and urinary creatinine levels. One-unit increases in log-transformed mono-(3-carboxypropyl) phthalate (MCPP) (odds ratio [OR]=1.24, 95% confidence interval [CI]=1.02-1.52) and mono(carboxynonyl) phthalate (MCNP) (OR=1.42, 95% CI=1.15-1.75) were positively associated with depression. When we stratified the urinary phthalate metabolites into quartiles, the highest quartiles (Q4) of MCNP (OR=2.57, 95% CI=1.25-5.27) and mono-n-butyl phthalate (MBP) (OR=2.40, 95% CI=1.10-5.22) were associated with depression compared with the lowest quartiles (Q1). Concentrations of urinary phthalate metabolites MCPP, MCNP, and MBP were positively associated with the risk of depression in a representative sample of the U.S. elderly population. However, the present cross-sectional study is hypothesis generating and the associations need to be investigated through further longitudinal studies. ",
keywords = "Aged, Aged, 80 and over, Biomarkers/urine, Cross-Sectional Studies, Data Interpretation, Statistical, Depression/epidemiology, Environmental Exposure/adverse effects, Environmental Pollutants/metabolism, Female, Humans, Male, Middle Aged, Nutrition Surveys, Phthalic Acids/metabolism, Surveys and Questionnaires, United States",
author = "Kyoung-Nam Kim and Yoon-Hyeong Choi and Youn-Hee Lim and Yun-Chul Hong",
note = "Copyright {\textcopyright} 2015 Elsevier Inc. All rights reserved.",
year = "2016",
doi = "10.1016/j.envres.2015.11.021",
language = "English",
volume = "145",
pages = "61--67",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Urinary phthalate metabolites and depression in an elderly population

T2 - National Health and Nutrition Examination Survey 2005-2012

AU - Kim, Kyoung-Nam

AU - Choi, Yoon-Hyeong

AU - Lim, Youn-Hee

AU - Hong, Yun-Chul

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2016

Y1 - 2016

N2 - Previous animal studies have demonstrated that phthalate exposure is associated with depression-like behaviors. However, no human study has explored this relationship. We explored the association between urinary phthalate metabolite concentrations and depression in a nationally representative sample of the U.S. elderly population. We analyzed 2030 participants aged 60 years or older with available data on phthalates and depression from the 2005 to 2012 National Health and Nutrition Examination Survey (NHANES). We selected 10 urinary phthalate metabolites with a weighted detection rate >60%. Depression was defined as a 9-item Patient Health Questionnaire score ≥10. The models were adjusted for age, sex, race/ethnicity, education level, income-to-poverty ratio, health insurance coverage, marital status, smoking status, alcohol consumption, moderate physical activity, body mass index, comorbidity status, NHANEs cycle, and urinary creatinine levels. One-unit increases in log-transformed mono-(3-carboxypropyl) phthalate (MCPP) (odds ratio [OR]=1.24, 95% confidence interval [CI]=1.02-1.52) and mono(carboxynonyl) phthalate (MCNP) (OR=1.42, 95% CI=1.15-1.75) were positively associated with depression. When we stratified the urinary phthalate metabolites into quartiles, the highest quartiles (Q4) of MCNP (OR=2.57, 95% CI=1.25-5.27) and mono-n-butyl phthalate (MBP) (OR=2.40, 95% CI=1.10-5.22) were associated with depression compared with the lowest quartiles (Q1). Concentrations of urinary phthalate metabolites MCPP, MCNP, and MBP were positively associated with the risk of depression in a representative sample of the U.S. elderly population. However, the present cross-sectional study is hypothesis generating and the associations need to be investigated through further longitudinal studies.

AB - Previous animal studies have demonstrated that phthalate exposure is associated with depression-like behaviors. However, no human study has explored this relationship. We explored the association between urinary phthalate metabolite concentrations and depression in a nationally representative sample of the U.S. elderly population. We analyzed 2030 participants aged 60 years or older with available data on phthalates and depression from the 2005 to 2012 National Health and Nutrition Examination Survey (NHANES). We selected 10 urinary phthalate metabolites with a weighted detection rate >60%. Depression was defined as a 9-item Patient Health Questionnaire score ≥10. The models were adjusted for age, sex, race/ethnicity, education level, income-to-poverty ratio, health insurance coverage, marital status, smoking status, alcohol consumption, moderate physical activity, body mass index, comorbidity status, NHANEs cycle, and urinary creatinine levels. One-unit increases in log-transformed mono-(3-carboxypropyl) phthalate (MCPP) (odds ratio [OR]=1.24, 95% confidence interval [CI]=1.02-1.52) and mono(carboxynonyl) phthalate (MCNP) (OR=1.42, 95% CI=1.15-1.75) were positively associated with depression. When we stratified the urinary phthalate metabolites into quartiles, the highest quartiles (Q4) of MCNP (OR=2.57, 95% CI=1.25-5.27) and mono-n-butyl phthalate (MBP) (OR=2.40, 95% CI=1.10-5.22) were associated with depression compared with the lowest quartiles (Q1). Concentrations of urinary phthalate metabolites MCPP, MCNP, and MBP were positively associated with the risk of depression in a representative sample of the U.S. elderly population. However, the present cross-sectional study is hypothesis generating and the associations need to be investigated through further longitudinal studies.

KW - Aged

KW - Aged, 80 and over

KW - Biomarkers/urine

KW - Cross-Sectional Studies

KW - Data Interpretation, Statistical

KW - Depression/epidemiology

KW - Environmental Exposure/adverse effects

KW - Environmental Pollutants/metabolism

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Nutrition Surveys

KW - Phthalic Acids/metabolism

KW - Surveys and Questionnaires

KW - United States

U2 - 10.1016/j.envres.2015.11.021

DO - 10.1016/j.envres.2015.11.021

M3 - Journal article

C2 - 26624239

VL - 145

SP - 61

EP - 67

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

ER -

ID: 230069764