Towards a standardized bioinformatics infrastructure for N- and O-glycomics
Publikation: Bidrag til tidsskrift › Review › fagfællebedømt
Dokumenter
- Towards a standardized bioinformatics infrastructure for N- and O-glycomics
Forlagets udgivne version, 1,07 MB, PDF-dokument
The mass spectrometry (MS)-based analysis of free polysaccharides and glycans released from proteins, lipids and proteoglycans increasingly relies on databases and software. Here, we review progress in the bioinformatics analysis of protein-released N- and O-linked glycans (N- and O-glycomics) and propose an e-infrastructure to overcome current deficits in data and experimental transparency. This workflow enables the standardized submission of MS-based glycomics information into the public repository UniCarb-DR. It implements the MIRAGE (Minimum Requirement for A Glycomics Experiment) reporting guidelines, storage of unprocessed MS data in the GlycoPOST repository and glycan structure registration using the GlyTouCan registry, thereby supporting the development and extension of a glycan structure knowledgebase.
Originalsprog | Engelsk |
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Artikelnummer | 3275 |
Tidsskrift | Nature Communications |
Vol/bind | 10 |
Udgave nummer | 1 |
Antal sider | 10 |
ISSN | 2041-1723 |
DOI | |
Status | Udgivet - 2019 |
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