Three distinct developmental pathways for adaptive and two IFN-γ-producing γδ T subsets in adult thymus
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Dokumenter
- Buus TB 2017 Nat Comms
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Murine γδ T cells include subsets that are programmed for distinct effector functions during their development in the thymus. Under pathological conditions, different γδ T cell subsets can be protective or can exacerbate a disease. Here we show that CD117, CD200 and CD371, together with other markers, identify seven developmental stages of γδ T cells. These seven stages can be divided into three distinct developmental pathways that are enriched for different TCRδ repertoires and exhibit characteristic expression patterns associated with adaptive (γδTn), IFN-γ-producing (γδT1) and IFN-γ/IL-4-co-producing γδ T cells (γδNKT). Developmental progression towards both IFN-γ-producing subsets can be induced by TCR signalling, and each pathway results in thymic emigration at a different stage. Finally, we show that γδT1 cells are the predominating IFN-γ-producing subset developing in the adult thymus. Thus, this study maps out three distinct development pathways that result in the programming of γδTn, γδT1 and γδNKT cells.
Originalsprog | Engelsk |
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Artikelnummer | 1911 |
Tidsskrift | Nature Communications |
Vol/bind | 8 |
Udgave nummer | 1911 |
Antal sider | 13 |
ISSN | 2041-1723 |
DOI | |
Status | Udgivet - 4 dec. 2017 |
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