Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74

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Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74. / Dasgupta, Asish; Mukherjee, Sayanti; Chaki, Shaswati; Dastidar, Sujata G; Hendricks, Oliver; Christensen, Jørn B; Kristiansen, Jette E.; Amaral, Leonard.

I: International Journal of Antimicrobial Agents, Bind 35, Nr. 2, 01.02.2010, s. 174-6.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Dasgupta, A, Mukherjee, S, Chaki, S, Dastidar, SG, Hendricks, O, Christensen, JB, Kristiansen, JE & Amaral, L 2010, 'Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74', International Journal of Antimicrobial Agents, bind 35, nr. 2, s. 174-6. https://doi.org/10.1016/j.ijantimicag.2009.09.027

APA

Dasgupta, A., Mukherjee, S., Chaki, S., Dastidar, S. G., Hendricks, O., Christensen, J. B., Kristiansen, J. E., & Amaral, L. (2010). Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74. International Journal of Antimicrobial Agents, 35(2), 174-6. https://doi.org/10.1016/j.ijantimicag.2009.09.027

Vancouver

Dasgupta A, Mukherjee S, Chaki S, Dastidar SG, Hendricks O, Christensen JB o.a. Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74. International Journal of Antimicrobial Agents. 2010 feb. 1;35(2):174-6. https://doi.org/10.1016/j.ijantimicag.2009.09.027

Author

Dasgupta, Asish ; Mukherjee, Sayanti ; Chaki, Shaswati ; Dastidar, Sujata G ; Hendricks, Oliver ; Christensen, Jørn B ; Kristiansen, Jette E. ; Amaral, Leonard. / Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74. I: International Journal of Antimicrobial Agents. 2010 ; Bind 35, Nr. 2. s. 174-6.

Bibtex

@article{147157610235482583a4bfb39e37ed83,
title = "Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74",
abstract = "When administered to mice at doses of 100microg/mouse and 200microg/mouse, thioridazine (TDZ) significantly protected animals from the lethality produced by a virulent strain of Salmonella enterica serovar Typhimurium and reduced the number of bacteria retrieved from the spleen, liver and heart blood. The protection conferred by TDZ against a virulent Salmonella infection is hypothesised to be due to a reduction in the 55kDa virulence protein of the outer membrane of the organism, as this protein is almost totally absent when the organism is exposed to the phenothiazine. It is further hypothesised that the reduction in the 55kDa virulence factor renders the organism susceptible to the action of hydrolytic enzymes of the neutrophil phagolysosome, whereas in the absence of exposure to TDZ intracellular ingestion and localisation of the phagocytosed bacterium does not result in killing owing to rapid induction of the two-step PmrA/B regulon that results in the eventual synthesis and insertion of lipid A into the nascent lipopolysaccharide layer of the outer membrane.",
keywords = "Animals, Anti-Infective Agents, Antibiotic Prophylaxis, Bacterial Proteins, Blood, Colony Count, Microbial, Liver, Male, Mice, Microbial Viability, Neutrophils, Salmonella Infections, Animal, Salmonella typhimurium, Spleen, Survival Analysis, Thioridazine, Virulence Factors",
author = "Asish Dasgupta and Sayanti Mukherjee and Shaswati Chaki and Dastidar, {Sujata G} and Oliver Hendricks and Christensen, {J{\o}rn B} and Kristiansen, {Jette E.} and Leonard Amaral",
note = "Copyright 2009 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.",
year = "2010",
month = feb,
day = "1",
doi = "10.1016/j.ijantimicag.2009.09.027",
language = "English",
volume = "35",
pages = "174--6",
journal = "International Journal of Antimicrobial Agents",
issn = "0924-8579",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Thioridazine protects the mouse from a virulent infection by Salmonella enterica serovar Typhimurium 74

AU - Dasgupta, Asish

AU - Mukherjee, Sayanti

AU - Chaki, Shaswati

AU - Dastidar, Sujata G

AU - Hendricks, Oliver

AU - Christensen, Jørn B

AU - Kristiansen, Jette E.

AU - Amaral, Leonard

N1 - Copyright 2009 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

PY - 2010/2/1

Y1 - 2010/2/1

N2 - When administered to mice at doses of 100microg/mouse and 200microg/mouse, thioridazine (TDZ) significantly protected animals from the lethality produced by a virulent strain of Salmonella enterica serovar Typhimurium and reduced the number of bacteria retrieved from the spleen, liver and heart blood. The protection conferred by TDZ against a virulent Salmonella infection is hypothesised to be due to a reduction in the 55kDa virulence protein of the outer membrane of the organism, as this protein is almost totally absent when the organism is exposed to the phenothiazine. It is further hypothesised that the reduction in the 55kDa virulence factor renders the organism susceptible to the action of hydrolytic enzymes of the neutrophil phagolysosome, whereas in the absence of exposure to TDZ intracellular ingestion and localisation of the phagocytosed bacterium does not result in killing owing to rapid induction of the two-step PmrA/B regulon that results in the eventual synthesis and insertion of lipid A into the nascent lipopolysaccharide layer of the outer membrane.

AB - When administered to mice at doses of 100microg/mouse and 200microg/mouse, thioridazine (TDZ) significantly protected animals from the lethality produced by a virulent strain of Salmonella enterica serovar Typhimurium and reduced the number of bacteria retrieved from the spleen, liver and heart blood. The protection conferred by TDZ against a virulent Salmonella infection is hypothesised to be due to a reduction in the 55kDa virulence protein of the outer membrane of the organism, as this protein is almost totally absent when the organism is exposed to the phenothiazine. It is further hypothesised that the reduction in the 55kDa virulence factor renders the organism susceptible to the action of hydrolytic enzymes of the neutrophil phagolysosome, whereas in the absence of exposure to TDZ intracellular ingestion and localisation of the phagocytosed bacterium does not result in killing owing to rapid induction of the two-step PmrA/B regulon that results in the eventual synthesis and insertion of lipid A into the nascent lipopolysaccharide layer of the outer membrane.

KW - Animals

KW - Anti-Infective Agents

KW - Antibiotic Prophylaxis

KW - Bacterial Proteins

KW - Blood

KW - Colony Count, Microbial

KW - Liver

KW - Male

KW - Mice

KW - Microbial Viability

KW - Neutrophils

KW - Salmonella Infections, Animal

KW - Salmonella typhimurium

KW - Spleen

KW - Survival Analysis

KW - Thioridazine

KW - Virulence Factors

U2 - 10.1016/j.ijantimicag.2009.09.027

DO - 10.1016/j.ijantimicag.2009.09.027

M3 - Journal article

C2 - 20005679

VL - 35

SP - 174

EP - 176

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

SN - 0924-8579

IS - 2

ER -

ID: 33247814