The prevalences of Salmonella Genomic Island 1 variants in human and animal Salmonella Typhimurium DT104 are distinguishable using a Bayesian approach
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The prevalences of Salmonella Genomic Island 1 variants in human and animal Salmonella Typhimurium DT104 are distinguishable using a Bayesian approach. / Mather, Alison E; Denwood, Matthew; Haydon, Daniel T; Matthews, Louise; Mellor, Dominic J; Coia, John E; Brown, Derek J; Reid, Stuart W J.
I: PLOS ONE, Bind 6, Nr. 11, 2011, s. e27220.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The prevalences of Salmonella Genomic Island 1 variants in human and animal Salmonella Typhimurium DT104 are distinguishable using a Bayesian approach
AU - Mather, Alison E
AU - Denwood, Matthew
AU - Haydon, Daniel T
AU - Matthews, Louise
AU - Mellor, Dominic J
AU - Coia, John E
AU - Brown, Derek J
AU - Reid, Stuart W J
PY - 2011
Y1 - 2011
N2 - Throughout the 1990 s, there was an epidemic of multidrug resistant Salmonella Typhimurium DT104 in both animals and humans in Scotland. The use of antimicrobials in agriculture is often cited as a major source of antimicrobial resistance in pathogenic bacteria of humans, suggesting that DT104 in animals and humans should demonstrate similar prevalences of resistance determinants. Until very recently, only the application of molecular methods would allow such a comparison and our understanding has been hindered by the fact that surveillance data are primarily phenotypic in nature. Here, using large scale surveillance datasets and a novel Bayesian approach, we infer and compare the prevalence of Salmonella Genomic Island 1 (SGI1), SGI1 variants, and resistance determinants independent of SGI1 in animal and human DT104 isolates from such phenotypic data. We demonstrate differences in the prevalences of SGI1, SGI1-B, SGI1-C, absence of SGI1, and tetracycline resistance determinants independent of SGI1 between these human and animal populations, a finding that challenges established tenets that DT104 in domestic animals and humans are from the same well-mixed microbial population.
AB - Throughout the 1990 s, there was an epidemic of multidrug resistant Salmonella Typhimurium DT104 in both animals and humans in Scotland. The use of antimicrobials in agriculture is often cited as a major source of antimicrobial resistance in pathogenic bacteria of humans, suggesting that DT104 in animals and humans should demonstrate similar prevalences of resistance determinants. Until very recently, only the application of molecular methods would allow such a comparison and our understanding has been hindered by the fact that surveillance data are primarily phenotypic in nature. Here, using large scale surveillance datasets and a novel Bayesian approach, we infer and compare the prevalence of Salmonella Genomic Island 1 (SGI1), SGI1 variants, and resistance determinants independent of SGI1 in animal and human DT104 isolates from such phenotypic data. We demonstrate differences in the prevalences of SGI1, SGI1-B, SGI1-C, absence of SGI1, and tetracycline resistance determinants independent of SGI1 between these human and animal populations, a finding that challenges established tenets that DT104 in domestic animals and humans are from the same well-mixed microbial population.
KW - Animals
KW - Anti-Bacterial Agents
KW - Bayes Theorem
KW - Drug Resistance, Multiple, Bacterial
KW - Gene Frequency
KW - Genetic Variation
KW - Genomic Islands
KW - Humans
KW - Markov Chains
KW - Monte Carlo Method
KW - Salmonella Infections
KW - Salmonella Infections, Animal
KW - Salmonella typhimurium
KW - Species Specificity
U2 - 10.1371/journal.pone.0027220
DO - 10.1371/journal.pone.0027220
M3 - Journal article
C2 - 22125606
VL - 6
SP - e27220
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 11
ER -
ID: 137015139