The plasma concentration of HDL-associated apolipoprotein M is influenced by LDL-receptor-mediated clearance of apoB-containing particles

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Standard

The plasma concentration of HDL-associated apolipoprotein M is influenced by LDL-receptor-mediated clearance of apoB-containing particles. / Christoffersen, Christina; Benn, Marianne; Christensen, Pernille Møller; Gordts, Philip L S M; Roebroek, Anton J M; Frikke-Schmidt, Ruth; Tybjaerg-Hansen, Anne; Dahlback, Bjorn; Nielsen, Lars Bo.

I: Journal of Lipid Research, 2012.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Christoffersen, C, Benn, M, Christensen, PM, Gordts, PLSM, Roebroek, AJM, Frikke-Schmidt, R, Tybjaerg-Hansen, A, Dahlback, B & Nielsen, LB 2012, 'The plasma concentration of HDL-associated apolipoprotein M is influenced by LDL-receptor-mediated clearance of apoB-containing particles', Journal of Lipid Research. https://doi.org/10.1194/jlr.P023697

APA

Christoffersen, C., Benn, M., Christensen, P. M., Gordts, P. L. S. M., Roebroek, A. J. M., Frikke-Schmidt, R., Tybjaerg-Hansen, A., Dahlback, B., & Nielsen, L. B. (2012). The plasma concentration of HDL-associated apolipoprotein M is influenced by LDL-receptor-mediated clearance of apoB-containing particles. Journal of Lipid Research. https://doi.org/10.1194/jlr.P023697

Vancouver

Christoffersen C, Benn M, Christensen PM, Gordts PLSM, Roebroek AJM, Frikke-Schmidt R o.a. The plasma concentration of HDL-associated apolipoprotein M is influenced by LDL-receptor-mediated clearance of apoB-containing particles. Journal of Lipid Research. 2012. https://doi.org/10.1194/jlr.P023697

Author

Christoffersen, Christina ; Benn, Marianne ; Christensen, Pernille Møller ; Gordts, Philip L S M ; Roebroek, Anton J M ; Frikke-Schmidt, Ruth ; Tybjaerg-Hansen, Anne ; Dahlback, Bjorn ; Nielsen, Lars Bo. / The plasma concentration of HDL-associated apolipoprotein M is influenced by LDL-receptor-mediated clearance of apoB-containing particles. I: Journal of Lipid Research. 2012.

Bibtex

@article{c0587edb3c26407a93b6e4301a0a1254,
title = "The plasma concentration of HDL-associated apolipoprotein M is influenced by LDL-receptor-mediated clearance of apoB-containing particles",
abstract = "Apolipoprotein (apo) M is mainly associated with HDL. Nevertheless, we have consistently observed positive correlations of apoM with plasma LDL cholesterol in humans. Moreover, LDL-receptor deficiency is associated with increased plasma apoM in mice. Here, we tested the idea that plasma apoM concentrations are affected by the rate of LDL-receptor mediated clearance of apoB-containing particles. We measured apoM in humans each carrying one of 3 different LDL-receptor mutations (n=9) or the apoB3500 mutation (n=12). These carriers had increased plasma apoM (1.34±0.13 µmol/L, P=0.003, and 1.23±0.10 µmol/l, P=0.02, respectively) as compared with non-carriers (0.93±0.04 µmol/L). When we injected human apoM-containing HDL into Wt (n=6) or LDL-receptor deficient mice (n=6), the removal of HDL-associated human apoM was delayed in the LDL-receptor deficient mice. After 2 hrs 54±5% versus 90±8% (P <0.005) of the initial amounts of human apoM remained in plasma of Wt and LDL-receptor deficient mice, respectively. Finally, we compared the turnover of radio-iodinated LDL and plasma apoM concentrations in 45 normocholesterolemic humans. There was a negative correlation between plasma apoM and the fractional catabolic rate of LDL (r=-0.38, P=0.009). These data suggest that the plasma clearance of apoM, despite apoM primarily being associated with HDL, is influenced by LDL-receptor mediated clearance of apoB-containing particles.",
author = "Christina Christoffersen and Marianne Benn and Christensen, {Pernille M{\o}ller} and Gordts, {Philip L S M} and Roebroek, {Anton J M} and Ruth Frikke-Schmidt and Anne Tybjaerg-Hansen and Bjorn Dahlback and Nielsen, {Lars Bo}",
year = "2012",
doi = "10.1194/jlr.P023697",
language = "English",
journal = "Journal of Lipid Research",
issn = "0022-2275",
publisher = "American Society for Biochemistry and Molecular Biology, Inc.",

}

RIS

TY - JOUR

T1 - The plasma concentration of HDL-associated apolipoprotein M is influenced by LDL-receptor-mediated clearance of apoB-containing particles

AU - Christoffersen, Christina

AU - Benn, Marianne

AU - Christensen, Pernille Møller

AU - Gordts, Philip L S M

AU - Roebroek, Anton J M

AU - Frikke-Schmidt, Ruth

AU - Tybjaerg-Hansen, Anne

AU - Dahlback, Bjorn

AU - Nielsen, Lars Bo

PY - 2012

Y1 - 2012

N2 - Apolipoprotein (apo) M is mainly associated with HDL. Nevertheless, we have consistently observed positive correlations of apoM with plasma LDL cholesterol in humans. Moreover, LDL-receptor deficiency is associated with increased plasma apoM in mice. Here, we tested the idea that plasma apoM concentrations are affected by the rate of LDL-receptor mediated clearance of apoB-containing particles. We measured apoM in humans each carrying one of 3 different LDL-receptor mutations (n=9) or the apoB3500 mutation (n=12). These carriers had increased plasma apoM (1.34±0.13 µmol/L, P=0.003, and 1.23±0.10 µmol/l, P=0.02, respectively) as compared with non-carriers (0.93±0.04 µmol/L). When we injected human apoM-containing HDL into Wt (n=6) or LDL-receptor deficient mice (n=6), the removal of HDL-associated human apoM was delayed in the LDL-receptor deficient mice. After 2 hrs 54±5% versus 90±8% (P <0.005) of the initial amounts of human apoM remained in plasma of Wt and LDL-receptor deficient mice, respectively. Finally, we compared the turnover of radio-iodinated LDL and plasma apoM concentrations in 45 normocholesterolemic humans. There was a negative correlation between plasma apoM and the fractional catabolic rate of LDL (r=-0.38, P=0.009). These data suggest that the plasma clearance of apoM, despite apoM primarily being associated with HDL, is influenced by LDL-receptor mediated clearance of apoB-containing particles.

AB - Apolipoprotein (apo) M is mainly associated with HDL. Nevertheless, we have consistently observed positive correlations of apoM with plasma LDL cholesterol in humans. Moreover, LDL-receptor deficiency is associated with increased plasma apoM in mice. Here, we tested the idea that plasma apoM concentrations are affected by the rate of LDL-receptor mediated clearance of apoB-containing particles. We measured apoM in humans each carrying one of 3 different LDL-receptor mutations (n=9) or the apoB3500 mutation (n=12). These carriers had increased plasma apoM (1.34±0.13 µmol/L, P=0.003, and 1.23±0.10 µmol/l, P=0.02, respectively) as compared with non-carriers (0.93±0.04 µmol/L). When we injected human apoM-containing HDL into Wt (n=6) or LDL-receptor deficient mice (n=6), the removal of HDL-associated human apoM was delayed in the LDL-receptor deficient mice. After 2 hrs 54±5% versus 90±8% (P <0.005) of the initial amounts of human apoM remained in plasma of Wt and LDL-receptor deficient mice, respectively. Finally, we compared the turnover of radio-iodinated LDL and plasma apoM concentrations in 45 normocholesterolemic humans. There was a negative correlation between plasma apoM and the fractional catabolic rate of LDL (r=-0.38, P=0.009). These data suggest that the plasma clearance of apoM, despite apoM primarily being associated with HDL, is influenced by LDL-receptor mediated clearance of apoB-containing particles.

U2 - 10.1194/jlr.P023697

DO - 10.1194/jlr.P023697

M3 - Journal article

C2 - 22826357

JO - Journal of Lipid Research

JF - Journal of Lipid Research

SN - 0022-2275

ER -

ID: 40317109