The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia

Publikation: Bidrag til tidsskriftReviewfagfællebedømt

Standard

The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia. / Sylow, Lykke; Tokarz, Victoria L; Richter, Erik A.; Klip, Amira.

I: Cell Metabolism, Bind 33, Nr. 4, 2021, s. 758-780.

Publikation: Bidrag til tidsskriftReviewfagfællebedømt

Harvard

Sylow, L, Tokarz, VL, Richter, EA & Klip, A 2021, 'The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia', Cell Metabolism, bind 33, nr. 4, s. 758-780. https://doi.org/10.1016/j.cmet.2021.03.020

APA

Sylow, L., Tokarz, V. L., Richter, E. A., & Klip, A. (2021). The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia. Cell Metabolism, 33(4), 758-780. https://doi.org/10.1016/j.cmet.2021.03.020

Vancouver

Sylow L, Tokarz VL, Richter EA, Klip A. The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia. Cell Metabolism. 2021;33(4):758-780. https://doi.org/10.1016/j.cmet.2021.03.020

Author

Sylow, Lykke ; Tokarz, Victoria L ; Richter, Erik A. ; Klip, Amira. / The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia. I: Cell Metabolism. 2021 ; Bind 33, Nr. 4. s. 758-780.

Bibtex

@article{276be2035c4d4fe3945019f859db82fc,
title = "The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia",
abstract = "As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle contraction or exercise with increased sensitivity to subsequent insulin stimulation. Insulin's dominating control of glucose metabolism is orchestrated by complex and highly regulated signaling cascades that elicit diverse and unique effects on skeletal muscle. We discuss the discoveries that have led to our current understanding of how insulin promotes glucose uptake in muscle. We also touch upon insulin access to muscle, and insulin signaling toward glycogen, lipid, and protein metabolism. We draw from human and rodent studies in vivo, isolated muscle preparations, and muscle cell cultures to home in on the molecular, biophysical, and structural elements mediating these responses. Finally, we offer some perspective on molecular defects that potentially underlie the failure of muscle to take up glucose efficiently during obesity and type 2 diabetes.",
author = "Lykke Sylow and Tokarz, {Victoria L} and Richter, {Erik A.} and Amira Klip",
note = "Copyright {\textcopyright} 2021 Elsevier Inc. All rights reserved.",
year = "2021",
doi = "10.1016/j.cmet.2021.03.020",
language = "English",
volume = "33",
pages = "758--780",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - The many actions of insulin in skeletal muscle, the paramount tissue determining glycemia

AU - Sylow, Lykke

AU - Tokarz, Victoria L

AU - Richter, Erik A.

AU - Klip, Amira

N1 - Copyright © 2021 Elsevier Inc. All rights reserved.

PY - 2021

Y1 - 2021

N2 - As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle contraction or exercise with increased sensitivity to subsequent insulin stimulation. Insulin's dominating control of glucose metabolism is orchestrated by complex and highly regulated signaling cascades that elicit diverse and unique effects on skeletal muscle. We discuss the discoveries that have led to our current understanding of how insulin promotes glucose uptake in muscle. We also touch upon insulin access to muscle, and insulin signaling toward glycogen, lipid, and protein metabolism. We draw from human and rodent studies in vivo, isolated muscle preparations, and muscle cell cultures to home in on the molecular, biophysical, and structural elements mediating these responses. Finally, we offer some perspective on molecular defects that potentially underlie the failure of muscle to take up glucose efficiently during obesity and type 2 diabetes.

AB - As the principal tissue for insulin-stimulated glucose disposal, skeletal muscle is a primary driver of whole-body glycemic control. Skeletal muscle also uniquely responds to muscle contraction or exercise with increased sensitivity to subsequent insulin stimulation. Insulin's dominating control of glucose metabolism is orchestrated by complex and highly regulated signaling cascades that elicit diverse and unique effects on skeletal muscle. We discuss the discoveries that have led to our current understanding of how insulin promotes glucose uptake in muscle. We also touch upon insulin access to muscle, and insulin signaling toward glycogen, lipid, and protein metabolism. We draw from human and rodent studies in vivo, isolated muscle preparations, and muscle cell cultures to home in on the molecular, biophysical, and structural elements mediating these responses. Finally, we offer some perspective on molecular defects that potentially underlie the failure of muscle to take up glucose efficiently during obesity and type 2 diabetes.

U2 - 10.1016/j.cmet.2021.03.020

DO - 10.1016/j.cmet.2021.03.020

M3 - Review

C2 - 33826918

VL - 33

SP - 758

EP - 780

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 4

ER -

ID: 259836499