The influence of high versus low sodium intake on blood pressure and haemodynamics in patients with morbid obesity

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The influence of high versus low sodium intake on blood pressure and haemodynamics in patients with morbid obesity. / Bonfils, Peter K; Taskiran, Mustafa; Damgaard, Morten; Goetze, Jens P; Floyd, Andrea K; Funch-Jensen, Peter; Kristiansen, Viggo B; Gadsbøll, Niels.

I: Journal of Hypertension, Bind 31, Nr. 11, 11.2013, s. 2220-9; discussion 2229.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Bonfils, PK, Taskiran, M, Damgaard, M, Goetze, JP, Floyd, AK, Funch-Jensen, P, Kristiansen, VB & Gadsbøll, N 2013, 'The influence of high versus low sodium intake on blood pressure and haemodynamics in patients with morbid obesity', Journal of Hypertension, bind 31, nr. 11, s. 2220-9; discussion 2229. https://doi.org/10.1097/HJH.0b013e328363c769

APA

Bonfils, P. K., Taskiran, M., Damgaard, M., Goetze, J. P., Floyd, A. K., Funch-Jensen, P., ... Gadsbøll, N. (2013). The influence of high versus low sodium intake on blood pressure and haemodynamics in patients with morbid obesity. Journal of Hypertension, 31(11), 2220-9; discussion 2229. https://doi.org/10.1097/HJH.0b013e328363c769

Vancouver

Bonfils PK, Taskiran M, Damgaard M, Goetze JP, Floyd AK, Funch-Jensen P o.a. The influence of high versus low sodium intake on blood pressure and haemodynamics in patients with morbid obesity. Journal of Hypertension. 2013 nov;31(11):2220-9; discussion 2229. https://doi.org/10.1097/HJH.0b013e328363c769

Author

Bonfils, Peter K ; Taskiran, Mustafa ; Damgaard, Morten ; Goetze, Jens P ; Floyd, Andrea K ; Funch-Jensen, Peter ; Kristiansen, Viggo B ; Gadsbøll, Niels. / The influence of high versus low sodium intake on blood pressure and haemodynamics in patients with morbid obesity. I: Journal of Hypertension. 2013 ; Bind 31, Nr. 11. s. 2220-9; discussion 2229.

Bibtex

@article{a8148d42cba54e0c8ada43a8ff260716,
title = "The influence of high versus low sodium intake on blood pressure and haemodynamics in patients with morbid obesity",
abstract = "BACKGROUND: Many patients with morbid obesity (BMI > 40 kg/m) have hypertension. The complex pathophysiological abnormalities linking hypertension to obesity have not been fully clarified, but abnormal sodium handling could be an important mechanism.METHOD: Therefore, we examined changes in body fluid compartments and haemodynamic responses (at rest and during exercise) after 5 days of a low-sodium diet (90 mmol/day) and 5 days of a high-sodium diet (250 mmol/day) in 12 morbidly obese, hypertensive patients; 12 morbidly obese, normotensive patients and 12 nonobese controls.RESULTS: High sodium intake as compared to low sodium intake was associated with an increase in plasma volume (obese, hypertensive patients: 5 ± 4{\%}; obese, normotensive patients: 10 ± 11{\%}; nonobese controls: 7 ± 6{\%}), cardiac output (CO) (obese, hypertensive patients: 17 ± 12{\%}; obese, normotensive patients: 20 ± 16{\%}; nonobese controls: 13 ± 14{\%}) and stroke volume (SV) (obese, hypertensive patients: 27 ± 26{\%}; obese, normotensive patients: 27 ± 24{\%}; nonobese controls: 18 ± 27{\%}) in all three groups with no differences between the groups. Despite an increase in CO during high salt intake, 24-h blood pressure (BP) was unchanged in patients and controls as a result of a reduction in total peripheral resistance (obese, hypertensive patients: -11 ± 11{\%}; obese, normotensive patients: -10 ± 12{\%}; nonobese controls: -5 ± 14{\%}). Similar changes were observed during an incremental bicycle exercise test wherein CO and SV were higher, whereas mean arterial BP was unchanged at each exercise level during high sodium intake.CONCLUSION: Despite substantial increases in CO and SV, we did not observe any significant change in BP during high sodium intake, neither in morbid obese patients nor in lean individuals.",
author = "Bonfils, {Peter K} and Mustafa Taskiran and Morten Damgaard and Goetze, {Jens P} and Floyd, {Andrea K} and Peter Funch-Jensen and Kristiansen, {Viggo B} and Niels Gadsb{\o}ll",
year = "2013",
month = "11",
doi = "10.1097/HJH.0b013e328363c769",
language = "English",
volume = "31",
pages = "2220--9; discussion 2229",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "11",

}

RIS

TY - JOUR

T1 - The influence of high versus low sodium intake on blood pressure and haemodynamics in patients with morbid obesity

AU - Bonfils, Peter K

AU - Taskiran, Mustafa

AU - Damgaard, Morten

AU - Goetze, Jens P

AU - Floyd, Andrea K

AU - Funch-Jensen, Peter

AU - Kristiansen, Viggo B

AU - Gadsbøll, Niels

PY - 2013/11

Y1 - 2013/11

N2 - BACKGROUND: Many patients with morbid obesity (BMI > 40 kg/m) have hypertension. The complex pathophysiological abnormalities linking hypertension to obesity have not been fully clarified, but abnormal sodium handling could be an important mechanism.METHOD: Therefore, we examined changes in body fluid compartments and haemodynamic responses (at rest and during exercise) after 5 days of a low-sodium diet (90 mmol/day) and 5 days of a high-sodium diet (250 mmol/day) in 12 morbidly obese, hypertensive patients; 12 morbidly obese, normotensive patients and 12 nonobese controls.RESULTS: High sodium intake as compared to low sodium intake was associated with an increase in plasma volume (obese, hypertensive patients: 5 ± 4%; obese, normotensive patients: 10 ± 11%; nonobese controls: 7 ± 6%), cardiac output (CO) (obese, hypertensive patients: 17 ± 12%; obese, normotensive patients: 20 ± 16%; nonobese controls: 13 ± 14%) and stroke volume (SV) (obese, hypertensive patients: 27 ± 26%; obese, normotensive patients: 27 ± 24%; nonobese controls: 18 ± 27%) in all three groups with no differences between the groups. Despite an increase in CO during high salt intake, 24-h blood pressure (BP) was unchanged in patients and controls as a result of a reduction in total peripheral resistance (obese, hypertensive patients: -11 ± 11%; obese, normotensive patients: -10 ± 12%; nonobese controls: -5 ± 14%). Similar changes were observed during an incremental bicycle exercise test wherein CO and SV were higher, whereas mean arterial BP was unchanged at each exercise level during high sodium intake.CONCLUSION: Despite substantial increases in CO and SV, we did not observe any significant change in BP during high sodium intake, neither in morbid obese patients nor in lean individuals.

AB - BACKGROUND: Many patients with morbid obesity (BMI > 40 kg/m) have hypertension. The complex pathophysiological abnormalities linking hypertension to obesity have not been fully clarified, but abnormal sodium handling could be an important mechanism.METHOD: Therefore, we examined changes in body fluid compartments and haemodynamic responses (at rest and during exercise) after 5 days of a low-sodium diet (90 mmol/day) and 5 days of a high-sodium diet (250 mmol/day) in 12 morbidly obese, hypertensive patients; 12 morbidly obese, normotensive patients and 12 nonobese controls.RESULTS: High sodium intake as compared to low sodium intake was associated with an increase in plasma volume (obese, hypertensive patients: 5 ± 4%; obese, normotensive patients: 10 ± 11%; nonobese controls: 7 ± 6%), cardiac output (CO) (obese, hypertensive patients: 17 ± 12%; obese, normotensive patients: 20 ± 16%; nonobese controls: 13 ± 14%) and stroke volume (SV) (obese, hypertensive patients: 27 ± 26%; obese, normotensive patients: 27 ± 24%; nonobese controls: 18 ± 27%) in all three groups with no differences between the groups. Despite an increase in CO during high salt intake, 24-h blood pressure (BP) was unchanged in patients and controls as a result of a reduction in total peripheral resistance (obese, hypertensive patients: -11 ± 11%; obese, normotensive patients: -10 ± 12%; nonobese controls: -5 ± 14%). Similar changes were observed during an incremental bicycle exercise test wherein CO and SV were higher, whereas mean arterial BP was unchanged at each exercise level during high sodium intake.CONCLUSION: Despite substantial increases in CO and SV, we did not observe any significant change in BP during high sodium intake, neither in morbid obese patients nor in lean individuals.

U2 - 10.1097/HJH.0b013e328363c769

DO - 10.1097/HJH.0b013e328363c769

M3 - Journal article

C2 - 23868085

VL - 31

SP - 2220-9; discussion 2229

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 11

ER -

ID: 120533436