The functions of pannier during Drosophila embryogenesis
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The functions of pannier during Drosophila embryogenesis. / Herranz, H; Morata, G.
I: Development (Cambridge, England), Bind 128, Nr. 23, 12.2001, s. 4837-46.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The functions of pannier during Drosophila embryogenesis
AU - Herranz, H
AU - Morata, G
PY - 2001/12
Y1 - 2001/12
N2 - The pannier (pnr) gene of Drosophila encodes a zinc-finger transcription factor of the GATA family and is involved in several developmental processes during embryonic and imaginal development. We report some novel aspects of the regulation and function of pnr during embryogenesis. Previous work has shown that pnr is activated by decapentaplegic (dpp) in early development, but we find that after stage 10, the roles are reversed and pnr becomes an upstream regulator of dpp. This function of pnr is necessary for the activation of the Dpp pathway in the epidermal cells implicated in dorsal closure and is not mediated by the JNK pathway, which is also necessary for Dpp activity in these cells. In addition, we show that pnr behaves as a selector-like gene in generating morphological diversity in the dorsoventral body axis. It is responsible for maintaining a subdivision of the dorsal half of the embryo into two distinct, dorsomedial and dorsolateral, regions, and also specifies the identity of the dorsomedial region. These results, together with prior work on its function in adults, suggest that pnr is a major factor in the genetic subdivision of the body of Drosophila.
AB - The pannier (pnr) gene of Drosophila encodes a zinc-finger transcription factor of the GATA family and is involved in several developmental processes during embryonic and imaginal development. We report some novel aspects of the regulation and function of pnr during embryogenesis. Previous work has shown that pnr is activated by decapentaplegic (dpp) in early development, but we find that after stage 10, the roles are reversed and pnr becomes an upstream regulator of dpp. This function of pnr is necessary for the activation of the Dpp pathway in the epidermal cells implicated in dorsal closure and is not mediated by the JNK pathway, which is also necessary for Dpp activity in these cells. In addition, we show that pnr behaves as a selector-like gene in generating morphological diversity in the dorsoventral body axis. It is responsible for maintaining a subdivision of the dorsal half of the embryo into two distinct, dorsomedial and dorsolateral, regions, and also specifies the identity of the dorsomedial region. These results, together with prior work on its function in adults, suggest that pnr is a major factor in the genetic subdivision of the body of Drosophila.
KW - Amino Acid Sequence
KW - Animals
KW - Body Patterning
KW - Drosophila
KW - Drosophila Proteins
KW - Gene Deletion
KW - Gene Expression Regulation, Developmental
KW - Genes, Insect
KW - Larva
KW - Molecular Sequence Data
KW - Mutation
KW - Phenotype
KW - Transcription Factors
M3 - Journal article
C2 - 11731463
VL - 128
SP - 4837
EP - 4846
JO - Development
JF - Development
SN - 0950-1991
IS - 23
ER -
ID: 119179991