The functions of pannier during Drosophila embryogenesis

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Standard

The functions of pannier during Drosophila embryogenesis. / Herranz, H; Morata, G.

I: Development (Cambridge, England), Bind 128, Nr. 23, 12.2001, s. 4837-46.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Herranz, H & Morata, G 2001, 'The functions of pannier during Drosophila embryogenesis', Development (Cambridge, England), bind 128, nr. 23, s. 4837-46.

APA

Herranz, H., & Morata, G. (2001). The functions of pannier during Drosophila embryogenesis. Development (Cambridge, England), 128(23), 4837-46.

Vancouver

Herranz H, Morata G. The functions of pannier during Drosophila embryogenesis. Development (Cambridge, England). 2001 dec.;128(23):4837-46.

Author

Herranz, H ; Morata, G. / The functions of pannier during Drosophila embryogenesis. I: Development (Cambridge, England). 2001 ; Bind 128, Nr. 23. s. 4837-46.

Bibtex

@article{a4cb92ea54514e448016b60dd3ae036d,
title = "The functions of pannier during Drosophila embryogenesis",
abstract = "The pannier (pnr) gene of Drosophila encodes a zinc-finger transcription factor of the GATA family and is involved in several developmental processes during embryonic and imaginal development. We report some novel aspects of the regulation and function of pnr during embryogenesis. Previous work has shown that pnr is activated by decapentaplegic (dpp) in early development, but we find that after stage 10, the roles are reversed and pnr becomes an upstream regulator of dpp. This function of pnr is necessary for the activation of the Dpp pathway in the epidermal cells implicated in dorsal closure and is not mediated by the JNK pathway, which is also necessary for Dpp activity in these cells. In addition, we show that pnr behaves as a selector-like gene in generating morphological diversity in the dorsoventral body axis. It is responsible for maintaining a subdivision of the dorsal half of the embryo into two distinct, dorsomedial and dorsolateral, regions, and also specifies the identity of the dorsomedial region. These results, together with prior work on its function in adults, suggest that pnr is a major factor in the genetic subdivision of the body of Drosophila.",
keywords = "Amino Acid Sequence, Animals, Body Patterning, Drosophila, Drosophila Proteins, Gene Deletion, Gene Expression Regulation, Developmental, Genes, Insect, Larva, Molecular Sequence Data, Mutation, Phenotype, Transcription Factors",
author = "H Herranz and G Morata",
year = "2001",
month = dec,
language = "English",
volume = "128",
pages = "4837--46",
journal = "Development",
issn = "0950-1991",
publisher = "The Company of Biologists",
number = "23",

}

RIS

TY - JOUR

T1 - The functions of pannier during Drosophila embryogenesis

AU - Herranz, H

AU - Morata, G

PY - 2001/12

Y1 - 2001/12

N2 - The pannier (pnr) gene of Drosophila encodes a zinc-finger transcription factor of the GATA family and is involved in several developmental processes during embryonic and imaginal development. We report some novel aspects of the regulation and function of pnr during embryogenesis. Previous work has shown that pnr is activated by decapentaplegic (dpp) in early development, but we find that after stage 10, the roles are reversed and pnr becomes an upstream regulator of dpp. This function of pnr is necessary for the activation of the Dpp pathway in the epidermal cells implicated in dorsal closure and is not mediated by the JNK pathway, which is also necessary for Dpp activity in these cells. In addition, we show that pnr behaves as a selector-like gene in generating morphological diversity in the dorsoventral body axis. It is responsible for maintaining a subdivision of the dorsal half of the embryo into two distinct, dorsomedial and dorsolateral, regions, and also specifies the identity of the dorsomedial region. These results, together with prior work on its function in adults, suggest that pnr is a major factor in the genetic subdivision of the body of Drosophila.

AB - The pannier (pnr) gene of Drosophila encodes a zinc-finger transcription factor of the GATA family and is involved in several developmental processes during embryonic and imaginal development. We report some novel aspects of the regulation and function of pnr during embryogenesis. Previous work has shown that pnr is activated by decapentaplegic (dpp) in early development, but we find that after stage 10, the roles are reversed and pnr becomes an upstream regulator of dpp. This function of pnr is necessary for the activation of the Dpp pathway in the epidermal cells implicated in dorsal closure and is not mediated by the JNK pathway, which is also necessary for Dpp activity in these cells. In addition, we show that pnr behaves as a selector-like gene in generating morphological diversity in the dorsoventral body axis. It is responsible for maintaining a subdivision of the dorsal half of the embryo into two distinct, dorsomedial and dorsolateral, regions, and also specifies the identity of the dorsomedial region. These results, together with prior work on its function in adults, suggest that pnr is a major factor in the genetic subdivision of the body of Drosophila.

KW - Amino Acid Sequence

KW - Animals

KW - Body Patterning

KW - Drosophila

KW - Drosophila Proteins

KW - Gene Deletion

KW - Gene Expression Regulation, Developmental

KW - Genes, Insect

KW - Larva

KW - Molecular Sequence Data

KW - Mutation

KW - Phenotype

KW - Transcription Factors

M3 - Journal article

C2 - 11731463

VL - 128

SP - 4837

EP - 4846

JO - Development

JF - Development

SN - 0950-1991

IS - 23

ER -

ID: 119179991