The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response
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The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response. / Thiel, S; Holmskov, U; Hviid, L; Laursen, S B; Jensenius, J C.
I: Clinical and Experimental Immunology, Bind 90, Nr. 1, 1992, s. 31-5.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response
AU - Thiel, S
AU - Holmskov, U
AU - Hviid, L
AU - Laursen, S B
AU - Jensenius, J C
N1 - Keywords: Acute-Phase Reaction; Carrier Proteins; Collectins; Humans; Lectins; Malaria, Falciparum; Surgical Procedures, Operative; Time Factors
PY - 1992
Y1 - 1992
N2 - Two ELISAs for estimating mannan-binding protein (MBP) were constructed and the concentration of MBP in plasma was followed in patients undergoing major surgery and in patients having a malarial attack. In both cases increases of MBP in the plasma were observed. The relative increase and the kinetics varied from person to person. The concentration of MBP increased between 1.5- and three-fold following surgery. In some patients an increase was seen at day 1 whereas in others the increase was not observed until days 3-9. In the malaria patients an increased level of MBP was maintained during 30 days of treatment with chloroquine. The relative increase in MBP was independent of the presurgery or premalaria levels.
AB - Two ELISAs for estimating mannan-binding protein (MBP) were constructed and the concentration of MBP in plasma was followed in patients undergoing major surgery and in patients having a malarial attack. In both cases increases of MBP in the plasma were observed. The relative increase and the kinetics varied from person to person. The concentration of MBP increased between 1.5- and three-fold following surgery. In some patients an increase was seen at day 1 whereas in others the increase was not observed until days 3-9. In the malaria patients an increased level of MBP was maintained during 30 days of treatment with chloroquine. The relative increase in MBP was independent of the presurgery or premalaria levels.
M3 - Journal article
C2 - 1395098
VL - 90
SP - 31
EP - 35
JO - Clinical and Experimental Immunology, Supplement
JF - Clinical and Experimental Immunology, Supplement
SN - 0964-2536
IS - 1
ER -
ID: 6748444