The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism

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Standard

The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism. / Metz, Sophia; Krarup, Nikolaj T.; Bryrup, Thomas; Støy, Julie; Andersson, Ehm A; Christoffersen, Christina; Neville, Matt J.; Christiansen, Malene R; Jonsson, Anna E; Witte, Daniel R.; Kampmann, Ulla; Nielsen, Lars B.; Jørgensen, Niklas R; Karpe, Fredrik; Grarup, Niels; Pedersen, Oluf; Kilpeläinen, Tuomas O; Hansen, Torben.

I: Journal of the Endocrine Society, Bind 6, Nr. 5, bvac034, 2022.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Metz, S, Krarup, NT, Bryrup, T, Støy, J, Andersson, EA, Christoffersen, C, Neville, MJ, Christiansen, MR, Jonsson, AE, Witte, DR, Kampmann, U, Nielsen, LB, Jørgensen, NR, Karpe, F, Grarup, N, Pedersen, O, Kilpeläinen, TO & Hansen, T 2022, 'The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism', Journal of the Endocrine Society, bind 6, nr. 5, bvac034. https://doi.org/10.1210/jendso/bvac034

APA

Metz, S., Krarup, N. T., Bryrup, T., Støy, J., Andersson, E. A., Christoffersen, C., Neville, M. J., Christiansen, M. R., Jonsson, A. E., Witte, D. R., Kampmann, U., Nielsen, L. B., Jørgensen, N. R., Karpe, F., Grarup, N., Pedersen, O., Kilpeläinen, T. O., & Hansen, T. (2022). The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism. Journal of the Endocrine Society, 6(5), [bvac034]. https://doi.org/10.1210/jendso/bvac034

Vancouver

Metz S, Krarup NT, Bryrup T, Støy J, Andersson EA, Christoffersen C o.a. The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism. Journal of the Endocrine Society. 2022;6(5). bvac034. https://doi.org/10.1210/jendso/bvac034

Author

Metz, Sophia ; Krarup, Nikolaj T. ; Bryrup, Thomas ; Støy, Julie ; Andersson, Ehm A ; Christoffersen, Christina ; Neville, Matt J. ; Christiansen, Malene R ; Jonsson, Anna E ; Witte, Daniel R. ; Kampmann, Ulla ; Nielsen, Lars B. ; Jørgensen, Niklas R ; Karpe, Fredrik ; Grarup, Niels ; Pedersen, Oluf ; Kilpeläinen, Tuomas O ; Hansen, Torben. / The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism. I: Journal of the Endocrine Society. 2022 ; Bind 6, Nr. 5.

Bibtex

@article{22a3896fc6f246068c5fd1c46331cc4e,
title = "The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism",
abstract = "Blood lipid levels are linked to the risk of cardiovascular disease and regulated by genetic factors. A low-frequency polymorphism Arg82Cys (rs72836561) in the membrane protein nepmucin, encoded by CD300LG, is associated with lower fasting concentration of high-density lipoprotein cholesterol (HDLc) and higher fasting triglycerides. However, whether the variant is linked to postprandial lipids and glycemic status remains elusive.Here, we augment the genetic effect of Arg82Cys on fasting plasma concentrations of HDL subclasses, postprandial lipemia after a standardized high-fat meal, and glycemic status to further untangle its role in HDL metabolism.We elucidated fasting associations with HDL subclasses in a population-based cohort study (Oxford BioBank, OBB), including 4522 healthy men and women. We investigated fasting and postprandial consequences on HDL metabolism in recall-by-genotype (RbG) studies (fasting: 20 carrier/20 noncarrier; postprandial: 7 carrier/17 noncarrier), and shed light on the synergistic interaction with glycemic status.A lower fasting plasma concentration of cholesterol in large HDL particles was found in healthy male carriers of the Cys82 polymorphism compared to noncarriers, both in the OBB (P = .004) and RbG studies (P = .005). In addition, the Cys82 polymorphism was associated with low fasting plasma concentrations of ApoA1 (P = .008) in the OBB cohort. On the contrary, we did not find differences in postprandial lipemia or 2-hour plasma glucose levels.Taken together, our results indicate an association between the Arg82Cys variant and a lower concentration of HDL particles and HDLc, especially in larger HDL subclasses, suggesting a link between nepmucin and HDLc metabolism or maturation.",
author = "Sophia Metz and Krarup, {Nikolaj T.} and Thomas Bryrup and Julie St{\o}y and Andersson, {Ehm A} and Christina Christoffersen and Neville, {Matt J.} and Christiansen, {Malene R} and Jonsson, {Anna E} and Witte, {Daniel R.} and Ulla Kampmann and Nielsen, {Lars B.} and J{\o}rgensen, {Niklas R} and Fredrik Karpe and Niels Grarup and Oluf Pedersen and Kilpel{\"a}inen, {Tuomas O} and Torben Hansen",
year = "2022",
doi = "10.1210/jendso/bvac034",
language = "English",
volume = "6",
journal = "Endocrine Research Communications",
issn = "0743-5800",
publisher = "Taylor & Francis",
number = "5",

}

RIS

TY - JOUR

T1 - The Arg82Cys Polymorphism of the Protein Nepmucin Implies a Role in HDL Metabolism

AU - Metz, Sophia

AU - Krarup, Nikolaj T.

AU - Bryrup, Thomas

AU - Støy, Julie

AU - Andersson, Ehm A

AU - Christoffersen, Christina

AU - Neville, Matt J.

AU - Christiansen, Malene R

AU - Jonsson, Anna E

AU - Witte, Daniel R.

AU - Kampmann, Ulla

AU - Nielsen, Lars B.

AU - Jørgensen, Niklas R

AU - Karpe, Fredrik

AU - Grarup, Niels

AU - Pedersen, Oluf

AU - Kilpeläinen, Tuomas O

AU - Hansen, Torben

PY - 2022

Y1 - 2022

N2 - Blood lipid levels are linked to the risk of cardiovascular disease and regulated by genetic factors. A low-frequency polymorphism Arg82Cys (rs72836561) in the membrane protein nepmucin, encoded by CD300LG, is associated with lower fasting concentration of high-density lipoprotein cholesterol (HDLc) and higher fasting triglycerides. However, whether the variant is linked to postprandial lipids and glycemic status remains elusive.Here, we augment the genetic effect of Arg82Cys on fasting plasma concentrations of HDL subclasses, postprandial lipemia after a standardized high-fat meal, and glycemic status to further untangle its role in HDL metabolism.We elucidated fasting associations with HDL subclasses in a population-based cohort study (Oxford BioBank, OBB), including 4522 healthy men and women. We investigated fasting and postprandial consequences on HDL metabolism in recall-by-genotype (RbG) studies (fasting: 20 carrier/20 noncarrier; postprandial: 7 carrier/17 noncarrier), and shed light on the synergistic interaction with glycemic status.A lower fasting plasma concentration of cholesterol in large HDL particles was found in healthy male carriers of the Cys82 polymorphism compared to noncarriers, both in the OBB (P = .004) and RbG studies (P = .005). In addition, the Cys82 polymorphism was associated with low fasting plasma concentrations of ApoA1 (P = .008) in the OBB cohort. On the contrary, we did not find differences in postprandial lipemia or 2-hour plasma glucose levels.Taken together, our results indicate an association between the Arg82Cys variant and a lower concentration of HDL particles and HDLc, especially in larger HDL subclasses, suggesting a link between nepmucin and HDLc metabolism or maturation.

AB - Blood lipid levels are linked to the risk of cardiovascular disease and regulated by genetic factors. A low-frequency polymorphism Arg82Cys (rs72836561) in the membrane protein nepmucin, encoded by CD300LG, is associated with lower fasting concentration of high-density lipoprotein cholesterol (HDLc) and higher fasting triglycerides. However, whether the variant is linked to postprandial lipids and glycemic status remains elusive.Here, we augment the genetic effect of Arg82Cys on fasting plasma concentrations of HDL subclasses, postprandial lipemia after a standardized high-fat meal, and glycemic status to further untangle its role in HDL metabolism.We elucidated fasting associations with HDL subclasses in a population-based cohort study (Oxford BioBank, OBB), including 4522 healthy men and women. We investigated fasting and postprandial consequences on HDL metabolism in recall-by-genotype (RbG) studies (fasting: 20 carrier/20 noncarrier; postprandial: 7 carrier/17 noncarrier), and shed light on the synergistic interaction with glycemic status.A lower fasting plasma concentration of cholesterol in large HDL particles was found in healthy male carriers of the Cys82 polymorphism compared to noncarriers, both in the OBB (P = .004) and RbG studies (P = .005). In addition, the Cys82 polymorphism was associated with low fasting plasma concentrations of ApoA1 (P = .008) in the OBB cohort. On the contrary, we did not find differences in postprandial lipemia or 2-hour plasma glucose levels.Taken together, our results indicate an association between the Arg82Cys variant and a lower concentration of HDL particles and HDLc, especially in larger HDL subclasses, suggesting a link between nepmucin and HDLc metabolism or maturation.

U2 - 10.1210/jendso/bvac034

DO - 10.1210/jendso/bvac034

M3 - Journal article

C2 - 35382499

VL - 6

JO - Endocrine Research Communications

JF - Endocrine Research Communications

SN - 0743-5800

IS - 5

M1 - bvac034

ER -

ID: 302067032