Systematic review on the current knowledge and use of single-cell RNA sequencing in head and neck cancer
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Systematic review on the current knowledge and use of single-cell RNA sequencing in head and neck cancer. / Stampe, Helene; Jakobsen, Kathrine Kronberg; Bendtsen, Simone Kloch; Grønhøj, Christian; von Buchwald, Christian.
I: APMIS, Bind 129, Nr. 11, 2021, s. 619-625.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Systematic review on the current knowledge and use of single-cell RNA sequencing in head and neck cancer
AU - Stampe, Helene
AU - Jakobsen, Kathrine Kronberg
AU - Bendtsen, Simone Kloch
AU - Grønhøj, Christian
AU - von Buchwald, Christian
N1 - Publisher Copyright: © 2021 Scandinavian Societies for Medical Microbiology and Pathology
PY - 2021
Y1 - 2021
N2 - Single-cell RNA sequencing (scRNA-seq) is a novel method enabling genetic characterization of tumor tissue at a single-cell level. This study systematically reviewed the literature on studies using scRNA-seq to characterize head and neck squamous cell carcinomas (HNSCCs). Seven studies were included, of which two studies performed scRNA-seq on 20 patients in total, and five studies used scRNA-seq data in a subsequent clinical study. The former mentioned two studies found intra-tumoral genetic heterogeneity among malignant cells but genetic uniformity among non-malignant cells. The five latter studies used scRNA-seq data in various ways. Three studies identified biomarkers related to predicting whether a patient would benefit from immunotherapeutic treatment. One study characterized genes related to the perineural invasion. One study identified genes to be used in diagnostics. Further studies performing scRNA-seq on HNSCC are required to continue the ongoing development and use of scRNA-seq.
AB - Single-cell RNA sequencing (scRNA-seq) is a novel method enabling genetic characterization of tumor tissue at a single-cell level. This study systematically reviewed the literature on studies using scRNA-seq to characterize head and neck squamous cell carcinomas (HNSCCs). Seven studies were included, of which two studies performed scRNA-seq on 20 patients in total, and five studies used scRNA-seq data in a subsequent clinical study. The former mentioned two studies found intra-tumoral genetic heterogeneity among malignant cells but genetic uniformity among non-malignant cells. The five latter studies used scRNA-seq data in various ways. Three studies identified biomarkers related to predicting whether a patient would benefit from immunotherapeutic treatment. One study characterized genes related to the perineural invasion. One study identified genes to be used in diagnostics. Further studies performing scRNA-seq on HNSCC are required to continue the ongoing development and use of scRNA-seq.
KW - head and neck cancer
KW - head and neck squamous cell carcinoma
KW - HNSCC
KW - scRNA-seq
KW - Single-cell RNA sequencing
U2 - 10.1111/apm.13173
DO - 10.1111/apm.13173
M3 - Review
C2 - 34561896
AN - SCOPUS:85117838737
VL - 129
SP - 619
EP - 625
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 11
ER -
ID: 302570354