Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways
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The proinflammatory cytokine IL-1beta induces apoptosis in pancreatic beta cells via pathways dependent on nuclear factor-kappaB (NF-kappaB), mitogen-activated protein kinase, and protein kinase C. We recently showed suppressor of cytokine signalling (SOCS)-3 to be a natural negative feedback regulator of IL-1beta- and IFN-gamma-mediated signalling in rat islets and beta cell lines, preventing their deleterious effects. However, the mechanisms underlying SOCS-3 inhibition of IL-1beta signalling and prevention against apoptosis remain unknown.
Originalsprog | Engelsk |
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Tidsskrift | Diabetologia |
Vol/bind | 47 |
Udgave nummer | 11 |
Sider (fra-til) | 1998-2011 |
Antal sider | 14 |
ISSN | 0012-186X |
DOI | |
Status | Udgivet - 1 nov. 2004 |
ID: 33902540