Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria. / Lennartz, Frank; Adams, Yvonne; Bengtsson, Anja; Olsen, Rebecca Wendelboe; Turner, Louise; Ndam, Nicaise T; Ecklu-Mensah, Gertrude Delali; Moussiliou, Azizath; Ofori, Michael F; Gamain, Benoit; Lusingu, John P.; Petersen, Jens Emil Vang; Wang, Christian William; Nunes-Silva, Sofia; Jespersen, Jakob Schmidt; Lau, Clinton K Y; Theander, Thor Grundtvig; Lavstsen, Thomas; Hviid, Lars; Higgins, Matthew K; Jensen, Anja Tatiana Ramstedt.

I: Cell Host & Microbe, Bind 21, Nr. 3, 08.03.2017, s. 403-414.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Lennartz, F, Adams, Y, Bengtsson, A, Olsen, RW, Turner, L, Ndam, NT, Ecklu-Mensah, GD, Moussiliou, A, Ofori, MF, Gamain, B, Lusingu, JP, Petersen, JEV, Wang, CW, Nunes-Silva, S, Jespersen, JS, Lau, CKY, Theander, TG, Lavstsen, T, Hviid, L, Higgins, MK & Jensen, ATR 2017, 'Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria', Cell Host & Microbe, bind 21, nr. 3, s. 403-414. https://doi.org/10.1016/j.chom.2017.02.009

APA

Lennartz, F., Adams, Y., Bengtsson, A., Olsen, R. W., Turner, L., Ndam, N. T., ... Jensen, A. T. R. (2017). Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria. Cell Host & Microbe, 21(3), 403-414. https://doi.org/10.1016/j.chom.2017.02.009

Vancouver

Lennartz F, Adams Y, Bengtsson A, Olsen RW, Turner L, Ndam NT o.a. Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria. Cell Host & Microbe. 2017 mar 8;21(3):403-414. https://doi.org/10.1016/j.chom.2017.02.009

Author

Lennartz, Frank ; Adams, Yvonne ; Bengtsson, Anja ; Olsen, Rebecca Wendelboe ; Turner, Louise ; Ndam, Nicaise T ; Ecklu-Mensah, Gertrude Delali ; Moussiliou, Azizath ; Ofori, Michael F ; Gamain, Benoit ; Lusingu, John P. ; Petersen, Jens Emil Vang ; Wang, Christian William ; Nunes-Silva, Sofia ; Jespersen, Jakob Schmidt ; Lau, Clinton K Y ; Theander, Thor Grundtvig ; Lavstsen, Thomas ; Hviid, Lars ; Higgins, Matthew K ; Jensen, Anja Tatiana Ramstedt. / Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria. I: Cell Host & Microbe. 2017 ; Bind 21, Nr. 3. s. 403-414.

Bibtex

@article{78e8c2c6482d476c92c36dfcde77f568,
title = "Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria",
abstract = "Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display parasite proteins of the PfEMP1 family that bind various endothelial receptors. Despite the importance of cerebral malaria, a binding phenotype linked to its symptoms has not been identified. Here, we used structural biology to determine how a group of PfEMP1 proteins interacts with intercellular adhesion molecule 1 (ICAM-1), allowing us to predict binders from a specific sequence motif alone. Analysis of multiple Plasmodium falciparum genomes showed that ICAM-1-binding PfEMP1s also interact with endothelial protein C receptor (EPCR), allowing infected erythrocytes to synergistically bind both receptors. Expression of these PfEMP1s, predicted to bind both ICAM-1 and EPCR, is associated with increased risk of developing cerebral malaria. This study therefore reveals an important PfEMP1-binding phenotype that could be targeted as part of a strategy to prevent cerebral malaria.",
author = "Frank Lennartz and Yvonne Adams and Anja Bengtsson and Olsen, {Rebecca Wendelboe} and Louise Turner and Ndam, {Nicaise T} and Ecklu-Mensah, {Gertrude Delali} and Azizath Moussiliou and Ofori, {Michael F} and Benoit Gamain and Lusingu, {John P.} and Petersen, {Jens Emil Vang} and Wang, {Christian William} and Sofia Nunes-Silva and Jespersen, {Jakob Schmidt} and Lau, {Clinton K Y} and Theander, {Thor Grundtvig} and Thomas Lavstsen and Lars Hviid and Higgins, {Matthew K} and Jensen, {Anja Tatiana Ramstedt}",
note = "Copyright {\circledC} 2017 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2017",
month = "3",
day = "8",
doi = "10.1016/j.chom.2017.02.009",
language = "English",
volume = "21",
pages = "403--414",
journal = "Cell Host & Microbe",
issn = "1931-3128",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - Structure-guided identification of a family of dual receptor-binding PfEMP1 that is associated with cerebral malaria

AU - Lennartz, Frank

AU - Adams, Yvonne

AU - Bengtsson, Anja

AU - Olsen, Rebecca Wendelboe

AU - Turner, Louise

AU - Ndam, Nicaise T

AU - Ecklu-Mensah, Gertrude Delali

AU - Moussiliou, Azizath

AU - Ofori, Michael F

AU - Gamain, Benoit

AU - Lusingu, John P.

AU - Petersen, Jens Emil Vang

AU - Wang, Christian William

AU - Nunes-Silva, Sofia

AU - Jespersen, Jakob Schmidt

AU - Lau, Clinton K Y

AU - Theander, Thor Grundtvig

AU - Lavstsen, Thomas

AU - Hviid, Lars

AU - Higgins, Matthew K

AU - Jensen, Anja Tatiana Ramstedt

N1 - Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2017/3/8

Y1 - 2017/3/8

N2 - Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display parasite proteins of the PfEMP1 family that bind various endothelial receptors. Despite the importance of cerebral malaria, a binding phenotype linked to its symptoms has not been identified. Here, we used structural biology to determine how a group of PfEMP1 proteins interacts with intercellular adhesion molecule 1 (ICAM-1), allowing us to predict binders from a specific sequence motif alone. Analysis of multiple Plasmodium falciparum genomes showed that ICAM-1-binding PfEMP1s also interact with endothelial protein C receptor (EPCR), allowing infected erythrocytes to synergistically bind both receptors. Expression of these PfEMP1s, predicted to bind both ICAM-1 and EPCR, is associated with increased risk of developing cerebral malaria. This study therefore reveals an important PfEMP1-binding phenotype that could be targeted as part of a strategy to prevent cerebral malaria.

AB - Cerebral malaria is a deadly outcome of infection by Plasmodium falciparum, occurring when parasite-infected erythrocytes accumulate in the brain. These erythrocytes display parasite proteins of the PfEMP1 family that bind various endothelial receptors. Despite the importance of cerebral malaria, a binding phenotype linked to its symptoms has not been identified. Here, we used structural biology to determine how a group of PfEMP1 proteins interacts with intercellular adhesion molecule 1 (ICAM-1), allowing us to predict binders from a specific sequence motif alone. Analysis of multiple Plasmodium falciparum genomes showed that ICAM-1-binding PfEMP1s also interact with endothelial protein C receptor (EPCR), allowing infected erythrocytes to synergistically bind both receptors. Expression of these PfEMP1s, predicted to bind both ICAM-1 and EPCR, is associated with increased risk of developing cerebral malaria. This study therefore reveals an important PfEMP1-binding phenotype that could be targeted as part of a strategy to prevent cerebral malaria.

U2 - 10.1016/j.chom.2017.02.009

DO - 10.1016/j.chom.2017.02.009

M3 - Journal article

C2 - 28279348

VL - 21

SP - 403

EP - 414

JO - Cell Host & Microbe

JF - Cell Host & Microbe

SN - 1931-3128

IS - 3

ER -

ID: 174111963