Site-selective three-component reaction for dual-functionalization of peptides
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
A site-selective dual-functionalization of peptides is presented, involving readily available maleimides as well as N-hydroxylamines. The modification proceeds through a three component 1,3-dipolar cycloaddition, forming a stable product. This was exemplified by the one-pot attachment of two molecular imaging moieties to a tumor binding cyclic peptide, and was extended to the conjugation of a DOTA chelator to a 12 kDa protein.
Originalsprog | Engelsk |
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Tidsskrift | Chemical Communications |
Vol/bind | 49 |
Udgave nummer | 19 |
Sider (fra-til) | 1936-1938 |
Antal sider | 3 |
ISSN | 1359-7345 |
DOI | |
Status | Udgivet - 2013 |
ID: 88717747