Simultaneous Assessment of White Matter Changes in Microstructure and Connectedness in the Blind Brain

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Simultaneous Assessment of White Matter Changes in Microstructure and Connectedness in the Blind Brain. / Reislev, Nina Linde; Dyrby, Tim Bjørn; Siebner, Hartwig Roman; Kupers, Ron; Ptito, Maurice.

I: Neural Plasticity, Bind 2016, 6029241, 2016.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Reislev, NL, Dyrby, TB, Siebner, HR, Kupers, R & Ptito, M 2016, 'Simultaneous Assessment of White Matter Changes in Microstructure and Connectedness in the Blind Brain', Neural Plasticity, bind 2016, 6029241. https://doi.org/10.1155/2016/6029241

APA

Reislev, N. L., Dyrby, T. B., Siebner, H. R., Kupers, R., & Ptito, M. (2016). Simultaneous Assessment of White Matter Changes in Microstructure and Connectedness in the Blind Brain. Neural Plasticity, 2016, [6029241]. https://doi.org/10.1155/2016/6029241

Vancouver

Reislev NL, Dyrby TB, Siebner HR, Kupers R, Ptito M. Simultaneous Assessment of White Matter Changes in Microstructure and Connectedness in the Blind Brain. Neural Plasticity. 2016;2016. 6029241. https://doi.org/10.1155/2016/6029241

Author

Reislev, Nina Linde ; Dyrby, Tim Bjørn ; Siebner, Hartwig Roman ; Kupers, Ron ; Ptito, Maurice. / Simultaneous Assessment of White Matter Changes in Microstructure and Connectedness in the Blind Brain. I: Neural Plasticity. 2016 ; Bind 2016.

Bibtex

@article{7bae374ecb654548bc9f9be18081ab67,
title = "Simultaneous Assessment of White Matter Changes in Microstructure and Connectedness in the Blind Brain",
abstract = "Magnetic resonance imaging (MRI) of the human brain has provided converging evidence that visual deprivation induces regional changes in white matter (WM) microstructure. It remains unclear how these changes modify network connections between brain regions. Here we used diffusion-weighted MRI to relate differences in microstructure and structural connectedness of WM in individuals with congenital or late-onset blindness relative to normally sighted controls. Diffusion tensor imaging (DTI) provided voxel-specific microstructural features of the tissue, while anatomical connectivity mapping (ACM) assessed the connectedness of each voxel with the rest of the brain. ACM yielded reduced anatomical connectivity in the corpus callosum in individuals with congenital but not late-onset blindness. ACM did not identify any brain region where blindness resulted in increased anatomical connectivity. DTI revealed widespread microstructural differences as indexed by a reduced regional fractional anisotropy (FA). Blind individuals showed lower FA in the primary visual and the ventral visual processing stream relative to sighted controls regardless of the blindness onset. The results show that visual deprivation shapes WM microstructure and anatomical connectivity, but these changes appear to be spatially dissociated as changes emerge in different WM tracts. They also indicate that regional differences in anatomical connectivity depend on the onset of blindness.",
author = "Reislev, {Nina Linde} and Dyrby, {Tim Bj{\o}rn} and Siebner, {Hartwig Roman} and Ron Kupers and Maurice Ptito",
year = "2016",
doi = "10.1155/2016/6029241",
language = "English",
volume = "2016",
journal = "Neural Plasticity",
issn = "2090-5904",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Simultaneous Assessment of White Matter Changes in Microstructure and Connectedness in the Blind Brain

AU - Reislev, Nina Linde

AU - Dyrby, Tim Bjørn

AU - Siebner, Hartwig Roman

AU - Kupers, Ron

AU - Ptito, Maurice

PY - 2016

Y1 - 2016

N2 - Magnetic resonance imaging (MRI) of the human brain has provided converging evidence that visual deprivation induces regional changes in white matter (WM) microstructure. It remains unclear how these changes modify network connections between brain regions. Here we used diffusion-weighted MRI to relate differences in microstructure and structural connectedness of WM in individuals with congenital or late-onset blindness relative to normally sighted controls. Diffusion tensor imaging (DTI) provided voxel-specific microstructural features of the tissue, while anatomical connectivity mapping (ACM) assessed the connectedness of each voxel with the rest of the brain. ACM yielded reduced anatomical connectivity in the corpus callosum in individuals with congenital but not late-onset blindness. ACM did not identify any brain region where blindness resulted in increased anatomical connectivity. DTI revealed widespread microstructural differences as indexed by a reduced regional fractional anisotropy (FA). Blind individuals showed lower FA in the primary visual and the ventral visual processing stream relative to sighted controls regardless of the blindness onset. The results show that visual deprivation shapes WM microstructure and anatomical connectivity, but these changes appear to be spatially dissociated as changes emerge in different WM tracts. They also indicate that regional differences in anatomical connectivity depend on the onset of blindness.

AB - Magnetic resonance imaging (MRI) of the human brain has provided converging evidence that visual deprivation induces regional changes in white matter (WM) microstructure. It remains unclear how these changes modify network connections between brain regions. Here we used diffusion-weighted MRI to relate differences in microstructure and structural connectedness of WM in individuals with congenital or late-onset blindness relative to normally sighted controls. Diffusion tensor imaging (DTI) provided voxel-specific microstructural features of the tissue, while anatomical connectivity mapping (ACM) assessed the connectedness of each voxel with the rest of the brain. ACM yielded reduced anatomical connectivity in the corpus callosum in individuals with congenital but not late-onset blindness. ACM did not identify any brain region where blindness resulted in increased anatomical connectivity. DTI revealed widespread microstructural differences as indexed by a reduced regional fractional anisotropy (FA). Blind individuals showed lower FA in the primary visual and the ventral visual processing stream relative to sighted controls regardless of the blindness onset. The results show that visual deprivation shapes WM microstructure and anatomical connectivity, but these changes appear to be spatially dissociated as changes emerge in different WM tracts. They also indicate that regional differences in anatomical connectivity depend on the onset of blindness.

U2 - 10.1155/2016/6029241

DO - 10.1155/2016/6029241

M3 - Journal article

C2 - 26881120

VL - 2016

JO - Neural Plasticity

JF - Neural Plasticity

SN - 2090-5904

M1 - 6029241

ER -

ID: 177096299