Serious clinical events in HIV-positive persons with chronic kidney disease

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Serious clinical events in HIV-positive persons with chronic kidney disease. / Ryom, Lene; Lundgren, Jens D; Law, Matthew; Kirk, Ole; El-Sadr, Wafaa; Bonnet, Fabrice; Weber, Rainer; Fontas, Eric; Monforte, Antonella d'Arminio; Phillips, Andrew; Reiss, Peter; de Wit, Stephane; Hatleberg, Camilla Ingrid; Sabin, Caroline; Mocroft, Amanda; D:A:D Study Group.

I: AIDS, Bind 33, Nr. 14, 2019, s. 2173-2188.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Ryom, L, Lundgren, JD, Law, M, Kirk, O, El-Sadr, W, Bonnet, F, Weber, R, Fontas, E, Monforte, ADA, Phillips, A, Reiss, P, de Wit, S, Hatleberg, CI, Sabin, C, Mocroft, A & D:A:D Study Group 2019, 'Serious clinical events in HIV-positive persons with chronic kidney disease', AIDS, bind 33, nr. 14, s. 2173-2188. https://doi.org/10.1097/QAD.0000000000002331

APA

Ryom, L., Lundgren, J. D., Law, M., Kirk, O., El-Sadr, W., Bonnet, F., Weber, R., Fontas, E., Monforte, A. DA., Phillips, A., Reiss, P., de Wit, S., Hatleberg, C. I., Sabin, C., Mocroft, A., & D:A:D Study Group (2019). Serious clinical events in HIV-positive persons with chronic kidney disease. AIDS, 33(14), 2173-2188. https://doi.org/10.1097/QAD.0000000000002331

Vancouver

Ryom L, Lundgren JD, Law M, Kirk O, El-Sadr W, Bonnet F o.a. Serious clinical events in HIV-positive persons with chronic kidney disease. AIDS. 2019;33(14):2173-2188. https://doi.org/10.1097/QAD.0000000000002331

Author

Ryom, Lene ; Lundgren, Jens D ; Law, Matthew ; Kirk, Ole ; El-Sadr, Wafaa ; Bonnet, Fabrice ; Weber, Rainer ; Fontas, Eric ; Monforte, Antonella d'Arminio ; Phillips, Andrew ; Reiss, Peter ; de Wit, Stephane ; Hatleberg, Camilla Ingrid ; Sabin, Caroline ; Mocroft, Amanda ; D:A:D Study Group. / Serious clinical events in HIV-positive persons with chronic kidney disease. I: AIDS. 2019 ; Bind 33, Nr. 14. s. 2173-2188.

Bibtex

@article{be71e573e3c441fabe461aecbfe5218e,
title = "Serious clinical events in HIV-positive persons with chronic kidney disease",
abstract = "OBJECTIVES: Predictors of chronic kidney disease (CKD) amongst HIV-positive persons are well established, but insights into the prognosis after CKD including the role of modifiable risk factors are limited.DESIGN: Prospective cohort study.METHODS: D:A:D participants developing CKD (confirmed, >3 months apart, eGFR ≤ 60 ml/min per 1.73 m or 25% eGFR decrease when eGFR ≤ 60 ml/min per 1.73 m) were followed to incident serious clinical events (SCE); end stage renal and liver disease (ESRL and ESLD), cardiovascular disease (CVD), AIDS-defining and non-AIDS-defining malignancies (NADM), other AIDS or death, 6 months after last visit or 1 February 2016. Poisson regression models considered associations between SCE and modifiable risk factors.RESULTS: During 2.7 (IQR 1.1-5.1) years median follow-up 595 persons with CKD (24.1%) developed a SCE [incidence rate 68.9/1000 PYFU (95% confidence interval 63.4-74.4)] with 8.3% (6.9-9.0) estimated to experience any SCE at 1 year. The most common SCE was death (12.7%), followed by NADM (5.8%), CVD (5.6%), other AIDS (5.0%) and ESRD (2.9%). Crude SCE ratios were significantly higher in those with vs. without CKD, strongest for ESRD [65.9 (43.8-100.9)] and death [4.8 (4.3-5.3)]. Smoking was consistently associated with all CKD-related SCE. Diabetes predicted CVD, NADM and death, whereas dyslipidaemia was only significantly associated with CVD. Poor HIV-status predicted other AIDS and death, eGFR less than 30 ml/min per 1.73 m predicted CVD and death and low BMI predicted other AIDS and death.CONCLUSION: In an era where many HIV-positive persons require less monitoring because of efficient antiretroviral treatment, persons with CKD carry a high burden of SCE. Several potentially modifiable risk factors play a central role for CKD-related morbidity and mortality.",
author = "Lene Ryom and Lundgren, {Jens D} and Matthew Law and Ole Kirk and Wafaa El-Sadr and Fabrice Bonnet and Rainer Weber and Eric Fontas and Monforte, {Antonella d'Arminio} and Andrew Phillips and Peter Reiss and {de Wit}, Stephane and Hatleberg, {Camilla Ingrid} and Caroline Sabin and Amanda Mocroft and {D:A:D Study Group}",
year = "2019",
doi = "10.1097/QAD.0000000000002331",
language = "English",
volume = "33",
pages = "2173--2188",
journal = "AIDS",
issn = "1350-2840",
publisher = "Lippincott Williams & Wilkins, Ltd.",
number = "14",

}

RIS

TY - JOUR

T1 - Serious clinical events in HIV-positive persons with chronic kidney disease

AU - Ryom, Lene

AU - Lundgren, Jens D

AU - Law, Matthew

AU - Kirk, Ole

AU - El-Sadr, Wafaa

AU - Bonnet, Fabrice

AU - Weber, Rainer

AU - Fontas, Eric

AU - Monforte, Antonella d'Arminio

AU - Phillips, Andrew

AU - Reiss, Peter

AU - de Wit, Stephane

AU - Hatleberg, Camilla Ingrid

AU - Sabin, Caroline

AU - Mocroft, Amanda

AU - D:A:D Study Group

PY - 2019

Y1 - 2019

N2 - OBJECTIVES: Predictors of chronic kidney disease (CKD) amongst HIV-positive persons are well established, but insights into the prognosis after CKD including the role of modifiable risk factors are limited.DESIGN: Prospective cohort study.METHODS: D:A:D participants developing CKD (confirmed, >3 months apart, eGFR ≤ 60 ml/min per 1.73 m or 25% eGFR decrease when eGFR ≤ 60 ml/min per 1.73 m) were followed to incident serious clinical events (SCE); end stage renal and liver disease (ESRL and ESLD), cardiovascular disease (CVD), AIDS-defining and non-AIDS-defining malignancies (NADM), other AIDS or death, 6 months after last visit or 1 February 2016. Poisson regression models considered associations between SCE and modifiable risk factors.RESULTS: During 2.7 (IQR 1.1-5.1) years median follow-up 595 persons with CKD (24.1%) developed a SCE [incidence rate 68.9/1000 PYFU (95% confidence interval 63.4-74.4)] with 8.3% (6.9-9.0) estimated to experience any SCE at 1 year. The most common SCE was death (12.7%), followed by NADM (5.8%), CVD (5.6%), other AIDS (5.0%) and ESRD (2.9%). Crude SCE ratios were significantly higher in those with vs. without CKD, strongest for ESRD [65.9 (43.8-100.9)] and death [4.8 (4.3-5.3)]. Smoking was consistently associated with all CKD-related SCE. Diabetes predicted CVD, NADM and death, whereas dyslipidaemia was only significantly associated with CVD. Poor HIV-status predicted other AIDS and death, eGFR less than 30 ml/min per 1.73 m predicted CVD and death and low BMI predicted other AIDS and death.CONCLUSION: In an era where many HIV-positive persons require less monitoring because of efficient antiretroviral treatment, persons with CKD carry a high burden of SCE. Several potentially modifiable risk factors play a central role for CKD-related morbidity and mortality.

AB - OBJECTIVES: Predictors of chronic kidney disease (CKD) amongst HIV-positive persons are well established, but insights into the prognosis after CKD including the role of modifiable risk factors are limited.DESIGN: Prospective cohort study.METHODS: D:A:D participants developing CKD (confirmed, >3 months apart, eGFR ≤ 60 ml/min per 1.73 m or 25% eGFR decrease when eGFR ≤ 60 ml/min per 1.73 m) were followed to incident serious clinical events (SCE); end stage renal and liver disease (ESRL and ESLD), cardiovascular disease (CVD), AIDS-defining and non-AIDS-defining malignancies (NADM), other AIDS or death, 6 months after last visit or 1 February 2016. Poisson regression models considered associations between SCE and modifiable risk factors.RESULTS: During 2.7 (IQR 1.1-5.1) years median follow-up 595 persons with CKD (24.1%) developed a SCE [incidence rate 68.9/1000 PYFU (95% confidence interval 63.4-74.4)] with 8.3% (6.9-9.0) estimated to experience any SCE at 1 year. The most common SCE was death (12.7%), followed by NADM (5.8%), CVD (5.6%), other AIDS (5.0%) and ESRD (2.9%). Crude SCE ratios were significantly higher in those with vs. without CKD, strongest for ESRD [65.9 (43.8-100.9)] and death [4.8 (4.3-5.3)]. Smoking was consistently associated with all CKD-related SCE. Diabetes predicted CVD, NADM and death, whereas dyslipidaemia was only significantly associated with CVD. Poor HIV-status predicted other AIDS and death, eGFR less than 30 ml/min per 1.73 m predicted CVD and death and low BMI predicted other AIDS and death.CONCLUSION: In an era where many HIV-positive persons require less monitoring because of efficient antiretroviral treatment, persons with CKD carry a high burden of SCE. Several potentially modifiable risk factors play a central role for CKD-related morbidity and mortality.

U2 - 10.1097/QAD.0000000000002331

DO - 10.1097/QAD.0000000000002331

M3 - Journal article

C2 - 31385862

VL - 33

SP - 2173

EP - 2188

JO - AIDS

JF - AIDS

SN - 1350-2840

IS - 14

ER -

ID: 237849759