SAC during early cell divisions: Sacrificing fidelity over timely division, regulated differently across organisms Chromosome alignment and segregation are left unsupervised from the onset of development until checkpoint activity is acquired, varying from species to species
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
SAC during early cell divisions : Sacrificing fidelity over timely division, regulated differently across organisms Chromosome alignment and segregation are left unsupervised from the onset of development until checkpoint activity is acquired, varying from species to species. / Duro, Joana; Nilsson, Jakob.
I: BioEssays, Bind 43, Nr. 3, 2000174, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - SAC during early cell divisions
T2 - Sacrificing fidelity over timely division, regulated differently across organisms Chromosome alignment and segregation are left unsupervised from the onset of development until checkpoint activity is acquired, varying from species to species
AU - Duro, Joana
AU - Nilsson, Jakob
PY - 2021
Y1 - 2021
N2 - Early embryogenesis is marked by a frail Spindle Assembly Checkpoint (SAC). The time of SAC acquisition varies depending on the species, cell size or a yet to be uncovered developmental timer. This means that for a specific number of divisions, biorientation of sister chromatids occurs unsupervised. When error-prone segregation is an issue, an aneuploidy-selective apoptosis system can come into play to eliminate chromosomally unbalanced cells resulting in healthy newborns. However, aneuploidy content can be too great to overcome, endangering viability.SAC generates a diffusible signal to lengthen time spent in mitosis if needed, ensuring correct chromosome segregation, a fundamental factor in the generation of euploid cells. Thus, it remains puzzling what benefit could come from delaying SAC acquisition till later in the development. In this review, we describe what is known on SAC acquisition in distinct species and highlight pending research as well as potential applications for such knowledge.
AB - Early embryogenesis is marked by a frail Spindle Assembly Checkpoint (SAC). The time of SAC acquisition varies depending on the species, cell size or a yet to be uncovered developmental timer. This means that for a specific number of divisions, biorientation of sister chromatids occurs unsupervised. When error-prone segregation is an issue, an aneuploidy-selective apoptosis system can come into play to eliminate chromosomally unbalanced cells resulting in healthy newborns. However, aneuploidy content can be too great to overcome, endangering viability.SAC generates a diffusible signal to lengthen time spent in mitosis if needed, ensuring correct chromosome segregation, a fundamental factor in the generation of euploid cells. Thus, it remains puzzling what benefit could come from delaying SAC acquisition till later in the development. In this review, we describe what is known on SAC acquisition in distinct species and highlight pending research as well as potential applications for such knowledge.
KW - aneuploidy
KW - chromosome segregation
KW - early embryogenesis
KW - SAC
KW - SPINDLE ASSEMBLY CHECKPOINT
KW - HUMAN PREIMPLANTATION EMBRYOS
KW - CYCLE CONTROL
KW - MIDBLASTULA TRANSITION
KW - MICROTUBULE-BINDING
KW - DNA-REPLICATION
KW - XENOPUS
KW - ATTACHMENT
KW - PROTEIN
KW - MPS1
U2 - 10.1002/bies.202000174
DO - 10.1002/bies.202000174
M3 - Journal article
C2 - 33251610
VL - 43
JO - BioEssays
JF - BioEssays
SN - 0265-9247
IS - 3
M1 - 2000174
ER -
ID: 253078466