Risk of asthma in adult twins with type 2 diabetes and increased body mass index
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Risk of asthma in adult twins with type 2 diabetes and increased body mass index. / Thomsen, S F; Duffy, D L; Kyvik, K O; Skytthe, A; Backer, V.
I: Allergy: European Journal of Allergy and Clinical Immunology, Bind 66, Nr. 4, 01.04.2011, s. 562-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Risk of asthma in adult twins with type 2 diabetes and increased body mass index
AU - Thomsen, S F
AU - Duffy, D L
AU - Kyvik, K O
AU - Skytthe, A
AU - Backer, V
N1 - © 2010 John Wiley & Sons A/S.
PY - 2011/4/1
Y1 - 2011/4/1
N2 - AIM:To examine the relationship between asthma, type 2 diabetes and increased body mass index (BMI) in adult twins.METHODS:We performed record linkage between questionnaire-defined asthma and BMI, and hospital discharge diagnoses of type 2 diabetes in 34,782 Danish twins, 20-71 years of age.RESULTS:The risk of asthma was increased in subjects with type 2 diabetes relative to nondiabetic subjects both in men (13.5%vs 7.5%), P = 0.001 and in women (16.6%vs 9.6%), P = 0.001. The result remained significant after adjustment for age, BMI, smoking, symptoms of chronic bronchitis, marital status and zygosity, men: OR = 1.70 (1.07-2.70), P = 0.026; women: OR = 1.88 (1.24-2.85), P = 0.003. In this analysis, BMI remained a highly significant predictor for asthma independently of diabetes status in women, P < 0.000 but not in men, P = 0.336. Significant positive genetic correlations were found between asthma and type 2 diabetes, 0.20 (0.01-0.40), P = 0.047; between asthma and BMI in women, 0.15 (0.07-0.22), P < 0.000; and between BMI and type 2 diabetes, 0.40 (0.29-0.43), P < 0.000.CONCLUSIONS:Asthma, type 2 diabetes and increased BMI are strongly associated in adults, particularly in women. These results suggest a common aetiology for asthma and metabolic syndrome.
AB - AIM:To examine the relationship between asthma, type 2 diabetes and increased body mass index (BMI) in adult twins.METHODS:We performed record linkage between questionnaire-defined asthma and BMI, and hospital discharge diagnoses of type 2 diabetes in 34,782 Danish twins, 20-71 years of age.RESULTS:The risk of asthma was increased in subjects with type 2 diabetes relative to nondiabetic subjects both in men (13.5%vs 7.5%), P = 0.001 and in women (16.6%vs 9.6%), P = 0.001. The result remained significant after adjustment for age, BMI, smoking, symptoms of chronic bronchitis, marital status and zygosity, men: OR = 1.70 (1.07-2.70), P = 0.026; women: OR = 1.88 (1.24-2.85), P = 0.003. In this analysis, BMI remained a highly significant predictor for asthma independently of diabetes status in women, P < 0.000 but not in men, P = 0.336. Significant positive genetic correlations were found between asthma and type 2 diabetes, 0.20 (0.01-0.40), P = 0.047; between asthma and BMI in women, 0.15 (0.07-0.22), P < 0.000; and between BMI and type 2 diabetes, 0.40 (0.29-0.43), P < 0.000.CONCLUSIONS:Asthma, type 2 diabetes and increased BMI are strongly associated in adults, particularly in women. These results suggest a common aetiology for asthma and metabolic syndrome.
U2 - 10.1111/j.1398-9995.2010.02504.x
DO - 10.1111/j.1398-9995.2010.02504.x
M3 - Journal article
C2 - 21083567
VL - 66
SP - 562
EP - 568
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
SN - 0105-4538
IS - 4
ER -
ID: 34096901