Risk Factors for Recurrence of Follicular Thyroid Cancer: A Systematic Review

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Standard

Risk Factors for Recurrence of Follicular Thyroid Cancer : A Systematic Review. / Grønlund, Mathias Peter; Jensen, Jakob Schmidt; Hahn, Christoffer Holst; Grønhøj, Christian; Buchwald, Christian Von.

I: Thyroid, Bind 31, Nr. 10, 01.10.2021, s. 1523-1530.

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Harvard

Grønlund, MP, Jensen, JS, Hahn, CH, Grønhøj, C & Buchwald, CV 2021, 'Risk Factors for Recurrence of Follicular Thyroid Cancer: A Systematic Review', Thyroid, bind 31, nr. 10, s. 1523-1530. https://doi.org/10.1089/thy.2020.0921

APA

Grønlund, M. P., Jensen, J. S., Hahn, C. H., Grønhøj, C., & Buchwald, C. V. (2021). Risk Factors for Recurrence of Follicular Thyroid Cancer: A Systematic Review. Thyroid, 31(10), 1523-1530. https://doi.org/10.1089/thy.2020.0921

Vancouver

Grønlund MP, Jensen JS, Hahn CH, Grønhøj C, Buchwald CV. Risk Factors for Recurrence of Follicular Thyroid Cancer: A Systematic Review. Thyroid. 2021 okt. 1;31(10):1523-1530. https://doi.org/10.1089/thy.2020.0921

Author

Grønlund, Mathias Peter ; Jensen, Jakob Schmidt ; Hahn, Christoffer Holst ; Grønhøj, Christian ; Buchwald, Christian Von. / Risk Factors for Recurrence of Follicular Thyroid Cancer : A Systematic Review. I: Thyroid. 2021 ; Bind 31, Nr. 10. s. 1523-1530.

Bibtex

@article{64a6a0fc0db647d3b756c09d3a8f82ae,
title = "Risk Factors for Recurrence of Follicular Thyroid Cancer: A Systematic Review",
abstract = "Background: In risk assessment of recurrence, papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) are often grouped together as differentiated thyroid cancer (DTC). However, while risk factors affecting recurrence of PTC are well established, risk factors for recurrence of FTC are not. This systematic review examines risk factors for recurrence of FTC and evaluates their significance. Methods: A systematic search on PubMed and Embase was performed in September 2020, including studies evaluating risk factors for recurrence of FTC. A quality assessment of the enrolled studies was performed. Results: Nine studies (n = 1544 patients) from eight countries were included. The average recurrence rate was 13.6%, and distant metastasis (DM) constituted 64.8% of the recurrent cases. The risk factors examined were sex, age at diagnosis, primary tumor size, degree of invasiveness, focality, positive resection margin, lymph node (LN) metastasis, and DM at diagnosis. Risk factors correlated with recurrence of FTC were age older than 45 years, primary tumor size above 40 mm, widespread invasion, multifocality, positive resection margin, LN metastasis, and DM at diagnosis. Sex was not a statistically significant risk factor. Conclusions: We identified seven risk factors associated with recurrence of FTC. Age and multifocality were found to be of greater impact regarding recurrence risk of FTC compared with PTC. Future research needs to address the impact of different risk factors for recurrence of FTC particularly including age, primary tumor size, angioinvasion, and mutational status. ",
keywords = "follicular thyroid cancer, recurrence, risk factors, systematic review",
author = "Gr{\o}nlund, {Mathias Peter} and Jensen, {Jakob Schmidt} and Hahn, {Christoffer Holst} and Christian Gr{\o}nh{\o}j and Buchwald, {Christian Von}",
note = "Publisher Copyright: {\textcopyright} 2021, Mary Ann Liebert, Inc., publishers 2021.",
year = "2021",
month = oct,
day = "1",
doi = "10.1089/thy.2020.0921",
language = "English",
volume = "31",
pages = "1523--1530",
journal = "Thyroid",
issn = "1050-7256",
publisher = "Mary AnnLiebert, Inc. Publishers",
number = "10",

}

RIS

TY - JOUR

T1 - Risk Factors for Recurrence of Follicular Thyroid Cancer

T2 - A Systematic Review

AU - Grønlund, Mathias Peter

AU - Jensen, Jakob Schmidt

AU - Hahn, Christoffer Holst

AU - Grønhøj, Christian

AU - Buchwald, Christian Von

N1 - Publisher Copyright: © 2021, Mary Ann Liebert, Inc., publishers 2021.

PY - 2021/10/1

Y1 - 2021/10/1

N2 - Background: In risk assessment of recurrence, papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) are often grouped together as differentiated thyroid cancer (DTC). However, while risk factors affecting recurrence of PTC are well established, risk factors for recurrence of FTC are not. This systematic review examines risk factors for recurrence of FTC and evaluates their significance. Methods: A systematic search on PubMed and Embase was performed in September 2020, including studies evaluating risk factors for recurrence of FTC. A quality assessment of the enrolled studies was performed. Results: Nine studies (n = 1544 patients) from eight countries were included. The average recurrence rate was 13.6%, and distant metastasis (DM) constituted 64.8% of the recurrent cases. The risk factors examined were sex, age at diagnosis, primary tumor size, degree of invasiveness, focality, positive resection margin, lymph node (LN) metastasis, and DM at diagnosis. Risk factors correlated with recurrence of FTC were age older than 45 years, primary tumor size above 40 mm, widespread invasion, multifocality, positive resection margin, LN metastasis, and DM at diagnosis. Sex was not a statistically significant risk factor. Conclusions: We identified seven risk factors associated with recurrence of FTC. Age and multifocality were found to be of greater impact regarding recurrence risk of FTC compared with PTC. Future research needs to address the impact of different risk factors for recurrence of FTC particularly including age, primary tumor size, angioinvasion, and mutational status.

AB - Background: In risk assessment of recurrence, papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC) are often grouped together as differentiated thyroid cancer (DTC). However, while risk factors affecting recurrence of PTC are well established, risk factors for recurrence of FTC are not. This systematic review examines risk factors for recurrence of FTC and evaluates their significance. Methods: A systematic search on PubMed and Embase was performed in September 2020, including studies evaluating risk factors for recurrence of FTC. A quality assessment of the enrolled studies was performed. Results: Nine studies (n = 1544 patients) from eight countries were included. The average recurrence rate was 13.6%, and distant metastasis (DM) constituted 64.8% of the recurrent cases. The risk factors examined were sex, age at diagnosis, primary tumor size, degree of invasiveness, focality, positive resection margin, lymph node (LN) metastasis, and DM at diagnosis. Risk factors correlated with recurrence of FTC were age older than 45 years, primary tumor size above 40 mm, widespread invasion, multifocality, positive resection margin, LN metastasis, and DM at diagnosis. Sex was not a statistically significant risk factor. Conclusions: We identified seven risk factors associated with recurrence of FTC. Age and multifocality were found to be of greater impact regarding recurrence risk of FTC compared with PTC. Future research needs to address the impact of different risk factors for recurrence of FTC particularly including age, primary tumor size, angioinvasion, and mutational status.

KW - follicular thyroid cancer

KW - recurrence

KW - risk factors

KW - systematic review

U2 - 10.1089/thy.2020.0921

DO - 10.1089/thy.2020.0921

M3 - Review

C2 - 34102860

AN - SCOPUS:85118374833

VL - 31

SP - 1523

EP - 1530

JO - Thyroid

JF - Thyroid

SN - 1050-7256

IS - 10

ER -

ID: 302555602