Resistance training and testosterone levels in male patients with chronic kidney disease undergoing dialysis

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Resistance training and testosterone levels in male patients with chronic kidney disease undergoing dialysis. / Molsted, Stig; Andersen, Jesper L.; Eidemak, Inge; Harrison, Adrian Paul; Jørgensen, Niels.

I: Journal of Biomedicine and Biotechnology, Bind 2014, 121273, 2014.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Molsted, S, Andersen, JL, Eidemak, I, Harrison, AP & Jørgensen, N 2014, 'Resistance training and testosterone levels in male patients with chronic kidney disease undergoing dialysis', Journal of Biomedicine and Biotechnology, bind 2014, 121273. https://doi.org/10.1155/2014/121273

APA

Molsted, S., Andersen, J. L., Eidemak, I., Harrison, A. P., & Jørgensen, N. (2014). Resistance training and testosterone levels in male patients with chronic kidney disease undergoing dialysis. Journal of Biomedicine and Biotechnology, 2014, [121273]. https://doi.org/10.1155/2014/121273

Vancouver

Molsted S, Andersen JL, Eidemak I, Harrison AP, Jørgensen N. Resistance training and testosterone levels in male patients with chronic kidney disease undergoing dialysis. Journal of Biomedicine and Biotechnology. 2014;2014. 121273. https://doi.org/10.1155/2014/121273

Author

Molsted, Stig ; Andersen, Jesper L. ; Eidemak, Inge ; Harrison, Adrian Paul ; Jørgensen, Niels. / Resistance training and testosterone levels in male patients with chronic kidney disease undergoing dialysis. I: Journal of Biomedicine and Biotechnology. 2014 ; Bind 2014.

Bibtex

@article{fa8dbaa5e17847048461a982cd09d82c,
title = "Resistance training and testosterone levels in male patients with chronic kidney disease undergoing dialysis",
abstract = "BACKGROUND: We investigated serum testosterone and insulin-like growth factor 1 (IGF-1) levels' associations with muscle fibre size and resistance training in male dialysis patients.METHODS: Male patients were included in a 16-week control period followed by 16 weeks of resistance training thrice weekly. Blood samples were obtained to analyse testosterone, luteinizing hormone (LH), IGF-1, and IGF-binding protein 3. Muscle fibres' size was analysed in biopsies from m. vastus lateralis.RESULTS: The patients' testosterone levels were within the normal range at baseline (n = 20) (19.5 (8.2-52.1) nmol/L versus 17.6 (16.1-18.0), resp.) whereas LH levels were higher (13.0 (5.5-82.8) U/L versus 4.3 (3.3-4.6), P < 0.001, resp.). IGF-1 and IGF-binding protein 3 levels were higher in the patients compared with reference values (203 (59-590) ng/mL versus 151 (128-276), P = 0.014, and 5045 (3370-9370) ng/mL versus 3244 (3020-3983), P < 0.001, resp.). All hormone levels and muscle fibre size (n = 12) remained stable throughout the study. Age-adjusted IGF-1 was associated with type 1 and 2 fibre sizes (P < 0.05).CONCLUSION: Patients' total testosterone values were normal due to markedly increased LH values, which suggest a compensated primary insufficiency of the testosterone producing Leydig cell. Even though testosterone values were normal, resistance training was not associated with muscle hypertrophy. This trial is registered with ISRCTN72099857.",
keywords = "Adult, Aged, Exercise, Humans, Insulin-Like Growth Factor Binding Protein 3, Insulin-Like Growth Factor I, Male, Middle Aged, Muscle Fibers, Skeletal, Organ Size, Renal Insufficiency, Chronic, Testosterone",
author = "Stig Molsted and Andersen, {Jesper L.} and Inge Eidemak and Harrison, {Adrian Paul} and Niels J{\o}rgensen",
year = "2014",
doi = "10.1155/2014/121273",
language = "English",
volume = "2014",
journal = "BioMed Research International",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Resistance training and testosterone levels in male patients with chronic kidney disease undergoing dialysis

AU - Molsted, Stig

AU - Andersen, Jesper L.

AU - Eidemak, Inge

AU - Harrison, Adrian Paul

AU - Jørgensen, Niels

PY - 2014

Y1 - 2014

N2 - BACKGROUND: We investigated serum testosterone and insulin-like growth factor 1 (IGF-1) levels' associations with muscle fibre size and resistance training in male dialysis patients.METHODS: Male patients were included in a 16-week control period followed by 16 weeks of resistance training thrice weekly. Blood samples were obtained to analyse testosterone, luteinizing hormone (LH), IGF-1, and IGF-binding protein 3. Muscle fibres' size was analysed in biopsies from m. vastus lateralis.RESULTS: The patients' testosterone levels were within the normal range at baseline (n = 20) (19.5 (8.2-52.1) nmol/L versus 17.6 (16.1-18.0), resp.) whereas LH levels were higher (13.0 (5.5-82.8) U/L versus 4.3 (3.3-4.6), P < 0.001, resp.). IGF-1 and IGF-binding protein 3 levels were higher in the patients compared with reference values (203 (59-590) ng/mL versus 151 (128-276), P = 0.014, and 5045 (3370-9370) ng/mL versus 3244 (3020-3983), P < 0.001, resp.). All hormone levels and muscle fibre size (n = 12) remained stable throughout the study. Age-adjusted IGF-1 was associated with type 1 and 2 fibre sizes (P < 0.05).CONCLUSION: Patients' total testosterone values were normal due to markedly increased LH values, which suggest a compensated primary insufficiency of the testosterone producing Leydig cell. Even though testosterone values were normal, resistance training was not associated with muscle hypertrophy. This trial is registered with ISRCTN72099857.

AB - BACKGROUND: We investigated serum testosterone and insulin-like growth factor 1 (IGF-1) levels' associations with muscle fibre size and resistance training in male dialysis patients.METHODS: Male patients were included in a 16-week control period followed by 16 weeks of resistance training thrice weekly. Blood samples were obtained to analyse testosterone, luteinizing hormone (LH), IGF-1, and IGF-binding protein 3. Muscle fibres' size was analysed in biopsies from m. vastus lateralis.RESULTS: The patients' testosterone levels were within the normal range at baseline (n = 20) (19.5 (8.2-52.1) nmol/L versus 17.6 (16.1-18.0), resp.) whereas LH levels were higher (13.0 (5.5-82.8) U/L versus 4.3 (3.3-4.6), P < 0.001, resp.). IGF-1 and IGF-binding protein 3 levels were higher in the patients compared with reference values (203 (59-590) ng/mL versus 151 (128-276), P = 0.014, and 5045 (3370-9370) ng/mL versus 3244 (3020-3983), P < 0.001, resp.). All hormone levels and muscle fibre size (n = 12) remained stable throughout the study. Age-adjusted IGF-1 was associated with type 1 and 2 fibre sizes (P < 0.05).CONCLUSION: Patients' total testosterone values were normal due to markedly increased LH values, which suggest a compensated primary insufficiency of the testosterone producing Leydig cell. Even though testosterone values were normal, resistance training was not associated with muscle hypertrophy. This trial is registered with ISRCTN72099857.

KW - Adult

KW - Aged

KW - Exercise

KW - Humans

KW - Insulin-Like Growth Factor Binding Protein 3

KW - Insulin-Like Growth Factor I

KW - Male

KW - Middle Aged

KW - Muscle Fibers, Skeletal

KW - Organ Size

KW - Renal Insufficiency, Chronic

KW - Testosterone

U2 - 10.1155/2014/121273

DO - 10.1155/2014/121273

M3 - Journal article

C2 - 24804194

VL - 2014

JO - BioMed Research International

JF - BioMed Research International

SN - 2314-6133

M1 - 121273

ER -

ID: 137739344