Regulation of beta cell replication.

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Standard

Regulation of beta cell replication. / Lee, Ying C; Nielsen, Jens Høiriis.

I: Molecular and Cellular Endocrinology, 2008.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lee, YC & Nielsen, JH 2008, 'Regulation of beta cell replication.', Molecular and Cellular Endocrinology. https://doi.org/10.1016/j.mce.2008.08.033

APA

Lee, Y. C., & Nielsen, J. H. (2008). Regulation of beta cell replication. Molecular and Cellular Endocrinology. https://doi.org/10.1016/j.mce.2008.08.033

Vancouver

Lee YC, Nielsen JH. Regulation of beta cell replication. Molecular and Cellular Endocrinology. 2008. https://doi.org/10.1016/j.mce.2008.08.033

Author

Lee, Ying C ; Nielsen, Jens Høiriis. / Regulation of beta cell replication. I: Molecular and Cellular Endocrinology. 2008.

Bibtex

@article{a99b5f90acd011ddb538000ea68e967b,
title = "Regulation of beta cell replication.",
abstract = "Beta cell mass, at any given time, is governed by cell differentiation, neogenesis, increased or decreased cell size (cell hypertrophy or atrophy), cell death (apoptosis), and beta cell proliferation. Nutrients, hormones and growth factors coupled with their signalling intermediates have been suggested to play a role in beta cell mass regulation. In addition, genetic mouse model studies have indicated that cyclins and cyclin-dependent kinases that determine cell cycle progression are involved in beta cell replication, and more recently, menin in association with cyclin-dependent kinase inhibitors has been demonstrated to be important in beta cell growth. In this review, we consider and highlight some aspects of cell cycle regulation in relation to beta cell replication. The role of cell cycle regulation in beta cell replication is mostly from studies in rodent models, but whether these findings can be extended to human beta cells remains to be shown.",
author = "Lee, {Ying C} and Nielsen, {Jens H{\o}iriis}",
year = "2008",
doi = "10.1016/j.mce.2008.08.033",
language = "English",
journal = "Molecular and Cellular Endocrinology",
issn = "0303-7207",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Regulation of beta cell replication.

AU - Lee, Ying C

AU - Nielsen, Jens Høiriis

PY - 2008

Y1 - 2008

N2 - Beta cell mass, at any given time, is governed by cell differentiation, neogenesis, increased or decreased cell size (cell hypertrophy or atrophy), cell death (apoptosis), and beta cell proliferation. Nutrients, hormones and growth factors coupled with their signalling intermediates have been suggested to play a role in beta cell mass regulation. In addition, genetic mouse model studies have indicated that cyclins and cyclin-dependent kinases that determine cell cycle progression are involved in beta cell replication, and more recently, menin in association with cyclin-dependent kinase inhibitors has been demonstrated to be important in beta cell growth. In this review, we consider and highlight some aspects of cell cycle regulation in relation to beta cell replication. The role of cell cycle regulation in beta cell replication is mostly from studies in rodent models, but whether these findings can be extended to human beta cells remains to be shown.

AB - Beta cell mass, at any given time, is governed by cell differentiation, neogenesis, increased or decreased cell size (cell hypertrophy or atrophy), cell death (apoptosis), and beta cell proliferation. Nutrients, hormones and growth factors coupled with their signalling intermediates have been suggested to play a role in beta cell mass regulation. In addition, genetic mouse model studies have indicated that cyclins and cyclin-dependent kinases that determine cell cycle progression are involved in beta cell replication, and more recently, menin in association with cyclin-dependent kinase inhibitors has been demonstrated to be important in beta cell growth. In this review, we consider and highlight some aspects of cell cycle regulation in relation to beta cell replication. The role of cell cycle regulation in beta cell replication is mostly from studies in rodent models, but whether these findings can be extended to human beta cells remains to be shown.

U2 - 10.1016/j.mce.2008.08.033

DO - 10.1016/j.mce.2008.08.033

M3 - Journal article

C2 - 18824066

JO - Molecular and Cellular Endocrinology

JF - Molecular and Cellular Endocrinology

SN - 0303-7207

ER -

ID: 8465452