Reduced levels of pulmonary surfactant in COVID-19 ARDS

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To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.

TidsskriftScientific Reports
Udgave nummer1
Antal sider5
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
The study was supported by the Lundbeck Foundation (Grant R349-2020-540).

Publisher Copyright:
© 2022, The Author(s).

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