Reduced levels of pulmonary surfactant in COVID-19 ARDS

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Standard

Reduced levels of pulmonary surfactant in COVID-19 ARDS. / Schousboe, Peter; Ronit, Andreas; Nielsen, Henning B.; Benfield, Thomas; Wiese, Lothar; Scoutaris, Nikolaos; Verder, Henrik; Berg, Ronan M.G.; Verder, Povl; Plovsing, Ronni R.

I: Scientific Reports, Bind 12, Nr. 1, 4040, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Schousboe, P, Ronit, A, Nielsen, HB, Benfield, T, Wiese, L, Scoutaris, N, Verder, H, Berg, RMG, Verder, P & Plovsing, RR 2022, 'Reduced levels of pulmonary surfactant in COVID-19 ARDS', Scientific Reports, bind 12, nr. 1, 4040. https://doi.org/10.1038/s41598-022-07944-4

APA

Schousboe, P., Ronit, A., Nielsen, H. B., Benfield, T., Wiese, L., Scoutaris, N., Verder, H., Berg, R. M. G., Verder, P., & Plovsing, R. R. (2022). Reduced levels of pulmonary surfactant in COVID-19 ARDS. Scientific Reports, 12(1), [4040]. https://doi.org/10.1038/s41598-022-07944-4

Vancouver

Schousboe P, Ronit A, Nielsen HB, Benfield T, Wiese L, Scoutaris N o.a. Reduced levels of pulmonary surfactant in COVID-19 ARDS. Scientific Reports. 2022;12(1). 4040. https://doi.org/10.1038/s41598-022-07944-4

Author

Schousboe, Peter ; Ronit, Andreas ; Nielsen, Henning B. ; Benfield, Thomas ; Wiese, Lothar ; Scoutaris, Nikolaos ; Verder, Henrik ; Berg, Ronan M.G. ; Verder, Povl ; Plovsing, Ronni R. / Reduced levels of pulmonary surfactant in COVID-19 ARDS. I: Scientific Reports. 2022 ; Bind 12, Nr. 1.

Bibtex

@article{39fe356991034eaba7bcce6160dbac3a,

title = "Reduced levels of pulmonary surfactant in COVID-19 ARDS",

abstract = "To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.",

author = "Peter Schousboe and Andreas Ronit and Nielsen, {Henning B.} and Thomas Benfield and Lothar Wiese and Nikolaos Scoutaris and Henrik Verder and Berg, {Ronan M.G.} and Povl Verder and Plovsing, {Ronni R.}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

doi = "10.1038/s41598-022-07944-4",

language = "English",

volume = "12",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "nature publishing group",

number = "1",

}

RIS

TY - JOUR

T1 - Reduced levels of pulmonary surfactant in COVID-19 ARDS

AU - Schousboe, Peter

AU - Ronit, Andreas

AU - Nielsen, Henning B.

AU - Benfield, Thomas

AU - Wiese, Lothar

AU - Scoutaris, Nikolaos

AU - Verder, Henrik

AU - Berg, Ronan M.G.

AU - Verder, Povl

AU - Plovsing, Ronni R.

PY - 2022

Y1 - 2022

N2 - To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.

AB - To provide novel data on surfactant levels in adult COVID-19 patients, we collected bronchoalveolar lavage fluid less than 72 h after intubation and used Fourier Transform Infrared Spectroscopy to measure levels of dipalmitoylphosphatidylcholine (DPPC). A total of eleven COVID-19 patients with moderate-to-severe ARDS (CARDS) and 15 healthy controls were included. CARDS patients had lower DPPC levels than healthy controls. Moreover, a principal component analysis was able to separate patient groups into distinguishable subgroups. Our findings indicate markedly impaired pulmonary surfactant levels in COVID-19 patients, justifying further studies and clinical trials of exogenous surfactant.

U2 - 10.1038/s41598-022-07944-4

DO - 10.1038/s41598-022-07944-4

M3 - Journal article

C2 - 35260704

AN - SCOPUS:85126080874

VL - 12

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 4040

ER -

ID: 302378375