Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians. / Meijsen, Joeri; Hu, Kejia; Krebs, Morten D.; Athanasiadis, Georgios; Washbrook, Sarah; Zetterberg, Richard; Avelar e Silva, Raquel Nogueira; Shorter, John R.; Gådin, Jesper R.; Bergstedt, Jacob; Howard, David M.; Ye, Weimin; Lu, Yi; Valdimarsdóttir, Unnur A.; Ingason, Andrés; Helenius, Dorte; Plana-Ripoll, Oleguer; McGrath, John J.; Micali, Nadia; Andreassen, Ole A.; Werge, Thomas M.; Fang, Fang; Buil, Alfonso.

I: Nature Communications, Bind 15, Nr. 1, 5064, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Meijsen, J, Hu, K, Krebs, MD, Athanasiadis, G, Washbrook, S, Zetterberg, R, Avelar e Silva, RN, Shorter, JR, Gådin, JR, Bergstedt, J, Howard, DM, Ye, W, Lu, Y, Valdimarsdóttir, UA, Ingason, A, Helenius, D, Plana-Ripoll, O, McGrath, JJ, Micali, N, Andreassen, OA, Werge, TM, Fang, F & Buil, A 2024, 'Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians', Nature Communications, bind 15, nr. 1, 5064. https://doi.org/10.1038/s41467-024-49507-3

APA

Meijsen, J., Hu, K., Krebs, M. D., Athanasiadis, G., Washbrook, S., Zetterberg, R., Avelar e Silva, R. N., Shorter, J. R., Gådin, J. R., Bergstedt, J., Howard, D. M., Ye, W., Lu, Y., Valdimarsdóttir, U. A., Ingason, A., Helenius, D., Plana-Ripoll, O., McGrath, J. J., Micali, N., ... Buil, A. (2024). Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians. Nature Communications, 15(1), [5064]. https://doi.org/10.1038/s41467-024-49507-3

Vancouver

Meijsen J, Hu K, Krebs MD, Athanasiadis G, Washbrook S, Zetterberg R o.a. Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians. Nature Communications. 2024;15(1). 5064. https://doi.org/10.1038/s41467-024-49507-3

Author

Meijsen, Joeri ; Hu, Kejia ; Krebs, Morten D. ; Athanasiadis, Georgios ; Washbrook, Sarah ; Zetterberg, Richard ; Avelar e Silva, Raquel Nogueira ; Shorter, John R. ; Gådin, Jesper R. ; Bergstedt, Jacob ; Howard, David M. ; Ye, Weimin ; Lu, Yi ; Valdimarsdóttir, Unnur A. ; Ingason, Andrés ; Helenius, Dorte ; Plana-Ripoll, Oleguer ; McGrath, John J. ; Micali, Nadia ; Andreassen, Ole A. ; Werge, Thomas M. ; Fang, Fang ; Buil, Alfonso. / Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians. I: Nature Communications. 2024 ; Bind 15, Nr. 1.

Bibtex

@article{8723f909725944c9965025c864b85372,
title = "Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians",
abstract = "Mental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records and near-complete genealogies of Denmark and Sweden (n = 17 million) to reveal the genetic and environmental contributions underlying the observed comorbidity between six mental disorders and 15 cardiometabolic disorders. Genetic factors contributed about 50% to the comorbidity of schizophrenia, affective disorders, and autism spectrum disorder with cardiometabolic disorders, whereas the comorbidity of attention-deficit/hyperactivity disorder and anorexia with cardiometabolic disorders was mainly or fully driven by environmental factors. In this work we provide causal insight to guide clinical and scientific initiatives directed at achieving mechanistic understanding as well as preventing and alleviating the consequences of these disorders.",
author = "Joeri Meijsen and Kejia Hu and Krebs, {Morten D.} and Georgios Athanasiadis and Sarah Washbrook and Richard Zetterberg and {Avelar e Silva}, {Raquel Nogueira} and Shorter, {John R.} and G{\aa}din, {Jesper R.} and Jacob Bergstedt and Howard, {David M.} and Weimin Ye and Yi Lu and Valdimarsd{\'o}ttir, {Unnur A.} and Andr{\'e}s Ingason and Dorte Helenius and Oleguer Plana-Ripoll and McGrath, {John J.} and Nadia Micali and Andreassen, {Ole A.} and Werge, {Thomas M.} and Fang Fang and Alfonso Buil",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",
year = "2024",
doi = "10.1038/s41467-024-49507-3",
language = "English",
volume = "15",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians

AU - Meijsen, Joeri

AU - Hu, Kejia

AU - Krebs, Morten D.

AU - Athanasiadis, Georgios

AU - Washbrook, Sarah

AU - Zetterberg, Richard

AU - Avelar e Silva, Raquel Nogueira

AU - Shorter, John R.

AU - Gådin, Jesper R.

AU - Bergstedt, Jacob

AU - Howard, David M.

AU - Ye, Weimin

AU - Lu, Yi

AU - Valdimarsdóttir, Unnur A.

AU - Ingason, Andrés

AU - Helenius, Dorte

AU - Plana-Ripoll, Oleguer

AU - McGrath, John J.

AU - Micali, Nadia

AU - Andreassen, Ole A.

AU - Werge, Thomas M.

AU - Fang, Fang

AU - Buil, Alfonso

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024

Y1 - 2024

N2 - Mental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records and near-complete genealogies of Denmark and Sweden (n = 17 million) to reveal the genetic and environmental contributions underlying the observed comorbidity between six mental disorders and 15 cardiometabolic disorders. Genetic factors contributed about 50% to the comorbidity of schizophrenia, affective disorders, and autism spectrum disorder with cardiometabolic disorders, whereas the comorbidity of attention-deficit/hyperactivity disorder and anorexia with cardiometabolic disorders was mainly or fully driven by environmental factors. In this work we provide causal insight to guide clinical and scientific initiatives directed at achieving mechanistic understanding as well as preventing and alleviating the consequences of these disorders.

AB - Mental disorders are leading causes of disability and premature death worldwide, partly due to high comorbidity with cardiometabolic disorders. Reasons for this comorbidity are still poorly understood. We leverage nation-wide health records and near-complete genealogies of Denmark and Sweden (n = 17 million) to reveal the genetic and environmental contributions underlying the observed comorbidity between six mental disorders and 15 cardiometabolic disorders. Genetic factors contributed about 50% to the comorbidity of schizophrenia, affective disorders, and autism spectrum disorder with cardiometabolic disorders, whereas the comorbidity of attention-deficit/hyperactivity disorder and anorexia with cardiometabolic disorders was mainly or fully driven by environmental factors. In this work we provide causal insight to guide clinical and scientific initiatives directed at achieving mechanistic understanding as well as preventing and alleviating the consequences of these disorders.

U2 - 10.1038/s41467-024-49507-3

DO - 10.1038/s41467-024-49507-3

M3 - Journal article

C2 - 38871766

AN - SCOPUS:85195946758

VL - 15

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 5064

ER -

ID: 395870592