Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons

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Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons. / Shepherd, Leah; Souberbielle, Jean-Claude; Bastard, Jean-Philippe; Fellahi, Soraya; Capeau, Jaqueline; Reekie, Joanne; Reiss, Peter; Blaxhult, Anders; Bickel, Markus; Leen, Clifford; Kirk, Ole; Lundgren, Jens D; Mocroft, Amanda; Viard, Jean-Paul; EuroSIDA in EuroCoord.

I: The Journal of Infectious Diseases, Bind 210, Nr. 2, 15.07.2014, s. 234-43.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Shepherd, L, Souberbielle, J-C, Bastard, J-P, Fellahi, S, Capeau, J, Reekie, J, Reiss, P, Blaxhult, A, Bickel, M, Leen, C, Kirk, O, Lundgren, JD, Mocroft, A, Viard, J-P & EuroSIDA in EuroCoord 2014, 'Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons', The Journal of Infectious Diseases, bind 210, nr. 2, s. 234-43. https://doi.org/10.1093/infdis/jiu074

APA

Shepherd, L., Souberbielle, J-C., Bastard, J-P., Fellahi, S., Capeau, J., Reekie, J., Reiss, P., Blaxhult, A., Bickel, M., Leen, C., Kirk, O., Lundgren, J. D., Mocroft, A., Viard, J-P., & EuroSIDA in EuroCoord (2014). Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons. The Journal of Infectious Diseases, 210(2), 234-43. https://doi.org/10.1093/infdis/jiu074

Vancouver

Shepherd L, Souberbielle J-C, Bastard J-P, Fellahi S, Capeau J, Reekie J o.a. Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons. The Journal of Infectious Diseases. 2014 jul. 15;210(2):234-43. https://doi.org/10.1093/infdis/jiu074

Author

Shepherd, Leah ; Souberbielle, Jean-Claude ; Bastard, Jean-Philippe ; Fellahi, Soraya ; Capeau, Jaqueline ; Reekie, Joanne ; Reiss, Peter ; Blaxhult, Anders ; Bickel, Markus ; Leen, Clifford ; Kirk, Ole ; Lundgren, Jens D ; Mocroft, Amanda ; Viard, Jean-Paul ; EuroSIDA in EuroCoord. / Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons. I: The Journal of Infectious Diseases. 2014 ; Bind 210, Nr. 2. s. 234-43.

Bibtex

@article{7f5f535f5d054ec3b34d35d3641ab1a1,
title = "Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons",
abstract = "BACKGROUND: Low 25-hydroxyvitamin D (25(OH)D) has been associated with inflammation, human immunodeficiency virus (HIV) disease progression, and death. We aimed to identify the prognostic value of 25(OH)D for AIDS, non-AIDS-defining events and death, and its association with immunological/inflammatory markers.METHODS: Prospective 1-1 case-control study nested within the EuroSIDA cohort. Matched cases and controls for AIDS (n = 50 matched pairs), non-AIDS-defining (n = 63) events and death (n = 41), with plasma samples during follow-up were selected. Conditional logistic regression models investigated associations between 25(OH)D levels and annual 25(OH)D change and the probability of events. Mixed models investigated relationships between 25(OH)D levels and immunological/inflammatory markers.RESULTS: In sum, 250 patients were included. Median time between first and last sample and last sample and event was 44.6(interquartile range [IQR]: 22.7-72.3) and 3.1(IQR: 1.4-6.4) months. Odds of death decreased by 46.0%(95% confidence interval [CI], 2.0-70.0, P = .04) for a 2-fold increase in latest 25(OH)D level. There was no association between 25(OH)D and the occurrence of AIDS or non-AIDS-defining events (P > .05). In patients with current 25(OH)D <10 ng/mL, hsIL-6 concentration increased by 4.7%(95% CI, .2,9.4, P = .04) annually after adjustment for immunological/inflammatory markers, and no change in hsCRP rate was observed (P = .76).CONCLUSIONS: Low Vitamin D predicts short term mortality in HIV-positive persons. Effectiveness of vitamin D supplementation on inflammation and patient outcomes should be investigated.",
keywords = "Adult, Biological Markers, Cohort Studies, Disease Progression, Female, HIV Infections, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Survival Analysis, Vitamin D",
author = "Leah Shepherd and Jean-Claude Souberbielle and Jean-Philippe Bastard and Soraya Fellahi and Jaqueline Capeau and Joanne Reekie and Peter Reiss and Anders Blaxhult and Markus Bickel and Clifford Leen and Ole Kirk and Lundgren, {Jens D} and Amanda Mocroft and Jean-Paul Viard and {EuroSIDA in EuroCoord}",
note = "{\textcopyright} The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.",
year = "2014",
month = jul,
day = "15",
doi = "10.1093/infdis/jiu074",
language = "English",
volume = "210",
pages = "234--43",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons

AU - Shepherd, Leah

AU - Souberbielle, Jean-Claude

AU - Bastard, Jean-Philippe

AU - Fellahi, Soraya

AU - Capeau, Jaqueline

AU - Reekie, Joanne

AU - Reiss, Peter

AU - Blaxhult, Anders

AU - Bickel, Markus

AU - Leen, Clifford

AU - Kirk, Ole

AU - Lundgren, Jens D

AU - Mocroft, Amanda

AU - Viard, Jean-Paul

AU - EuroSIDA in EuroCoord

N1 - © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

PY - 2014/7/15

Y1 - 2014/7/15

N2 - BACKGROUND: Low 25-hydroxyvitamin D (25(OH)D) has been associated with inflammation, human immunodeficiency virus (HIV) disease progression, and death. We aimed to identify the prognostic value of 25(OH)D for AIDS, non-AIDS-defining events and death, and its association with immunological/inflammatory markers.METHODS: Prospective 1-1 case-control study nested within the EuroSIDA cohort. Matched cases and controls for AIDS (n = 50 matched pairs), non-AIDS-defining (n = 63) events and death (n = 41), with plasma samples during follow-up were selected. Conditional logistic regression models investigated associations between 25(OH)D levels and annual 25(OH)D change and the probability of events. Mixed models investigated relationships between 25(OH)D levels and immunological/inflammatory markers.RESULTS: In sum, 250 patients were included. Median time between first and last sample and last sample and event was 44.6(interquartile range [IQR]: 22.7-72.3) and 3.1(IQR: 1.4-6.4) months. Odds of death decreased by 46.0%(95% confidence interval [CI], 2.0-70.0, P = .04) for a 2-fold increase in latest 25(OH)D level. There was no association between 25(OH)D and the occurrence of AIDS or non-AIDS-defining events (P > .05). In patients with current 25(OH)D <10 ng/mL, hsIL-6 concentration increased by 4.7%(95% CI, .2,9.4, P = .04) annually after adjustment for immunological/inflammatory markers, and no change in hsCRP rate was observed (P = .76).CONCLUSIONS: Low Vitamin D predicts short term mortality in HIV-positive persons. Effectiveness of vitamin D supplementation on inflammation and patient outcomes should be investigated.

AB - BACKGROUND: Low 25-hydroxyvitamin D (25(OH)D) has been associated with inflammation, human immunodeficiency virus (HIV) disease progression, and death. We aimed to identify the prognostic value of 25(OH)D for AIDS, non-AIDS-defining events and death, and its association with immunological/inflammatory markers.METHODS: Prospective 1-1 case-control study nested within the EuroSIDA cohort. Matched cases and controls for AIDS (n = 50 matched pairs), non-AIDS-defining (n = 63) events and death (n = 41), with plasma samples during follow-up were selected. Conditional logistic regression models investigated associations between 25(OH)D levels and annual 25(OH)D change and the probability of events. Mixed models investigated relationships between 25(OH)D levels and immunological/inflammatory markers.RESULTS: In sum, 250 patients were included. Median time between first and last sample and last sample and event was 44.6(interquartile range [IQR]: 22.7-72.3) and 3.1(IQR: 1.4-6.4) months. Odds of death decreased by 46.0%(95% confidence interval [CI], 2.0-70.0, P = .04) for a 2-fold increase in latest 25(OH)D level. There was no association between 25(OH)D and the occurrence of AIDS or non-AIDS-defining events (P > .05). In patients with current 25(OH)D <10 ng/mL, hsIL-6 concentration increased by 4.7%(95% CI, .2,9.4, P = .04) annually after adjustment for immunological/inflammatory markers, and no change in hsCRP rate was observed (P = .76).CONCLUSIONS: Low Vitamin D predicts short term mortality in HIV-positive persons. Effectiveness of vitamin D supplementation on inflammation and patient outcomes should be investigated.

KW - Adult

KW - Biological Markers

KW - Cohort Studies

KW - Disease Progression

KW - Female

KW - HIV Infections

KW - Humans

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Prospective Studies

KW - Survival Analysis

KW - Vitamin D

U2 - 10.1093/infdis/jiu074

DO - 10.1093/infdis/jiu074

M3 - Journal article

C2 - 24493824

VL - 210

SP - 234

EP - 243

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 2

ER -

ID: 137199994