Objectives: The purpose of this study was to examine whether peak oxygen uptake (pVO₂) and other cardiopulmonary exercise test (CPET)-derived variables could predict intermediate-term mortality in stable continuous flow LVAD recipients. Background: pVO₂ is a cornerstone in the selection of patients for heart transplantation, but the prognostic power of pVO₂ obtained in patients treated with a left ventricular assist device (LVAD) is unknown. Methods: We collected data for pVO₂ and outcomes in adult LVAD recipients in a retrospective, multicenter study and evaluated cutoff values for pVO₂ including: 1) values above or below medians; 2) grouping patients in tertiles; and 3) pVO₂ ≤14 ml/kg/min if the patient was not treated with beta-blockers (BB) or pVO₂ ≤12 ml/kg/min if the patient was taking BB therapy. Results: Nine centers contributed data from 450 patients. Patients were 53 ± 13 years of age; 78% were male; body mass index was 25 ± 5 kg/m² with few comorbidities (stroke: 11%; diabetes: 18%; and peripheral artery disease: 4%). The cause of heart failure (HF) was most often nonischemic (66%). Devices included were the HeartMate II and 3 (Abbott); and Heartware ventricular assist devices Jarvik and Duraheart (Medtronic). The index CPET was performed at a median of 189 days (154-225 days) after LVAD implantation, and mean pVO₂ was 14.1 ± 5 ml/kg/min (47% ± 14% of predicted value). Lower pVO₂ values were strongly associated with poorer survival regardless of whether patients were analyzed for absolute pVO₂ in ml/kg/min, pVO₂ ≤12 BB/14 ml/kg/min, or as a percentage of predicted pVO₂ values (P ≤ 0.001 for all). For patients with pVO₂ >12 BB/14 and ventilation/carbon dioxide relationship (VE/VCO₂) slope <35, the 1-year survival was 100%. Conclusions: Even after LVAD implantation, pVO₂ has prognostic value, similar to HF patients not supported by mechanical circulatory support devices. (PROgnostic Value of Exercise Capacity Measured as Peak Oxygen Uptake [pVO₂] in Recipients of Left Ventricular Assist Devices [PRO-VAD]; NCT04423562)