A Danish 73 year-old male patient with polymyalgia rheumatica and in prednisone treatment presented with a cutaneous ulcer on the hand caused by a scratch from a pigeon. Initial treatment with antibiotics was unsuccessful. Biopsy revealed Cryptococcus neoformans and the patient recovered on antifungal treatment. Primary cutaneous cryptococcosis is a rare manifestation of a C. neoformans infection. This case exemplifies the importance of differential diagnosis in immunosuppressed patients who do not respond to a given treatment.