Prenatal and early childhood phthalate exposures and thyroid function among school-age children

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Prenatal and early childhood phthalate exposures and thyroid function among school-age children. / Kim, Kyoung-Nam; Kim, Hwa Young; Lim, Youn-Hee; Shin, Choong Ho; Kim, Johanna Inhyang; Kim, Bung-Nyun; Lee, Young Ah; Hong, Yun-Chul.

I: Environment International, Bind 141, 105782, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Kim, K-N, Kim, HY, Lim, Y-H, Shin, CH, Kim, JI, Kim, B-N, Lee, YA & Hong, Y-C 2020, 'Prenatal and early childhood phthalate exposures and thyroid function among school-age children', Environment International, bind 141, 105782. https://doi.org/10.1016/j.envint.2020.105782

APA

Kim, K-N., Kim, H. Y., Lim, Y-H., Shin, C. H., Kim, J. I., Kim, B-N., Lee, Y. A., & Hong, Y-C. (2020). Prenatal and early childhood phthalate exposures and thyroid function among school-age children. Environment International, 141, [105782]. https://doi.org/10.1016/j.envint.2020.105782

Vancouver

Kim K-N, Kim HY, Lim Y-H, Shin CH, Kim JI, Kim B-N o.a. Prenatal and early childhood phthalate exposures and thyroid function among school-age children. Environment International. 2020;141. 105782. https://doi.org/10.1016/j.envint.2020.105782

Author

Kim, Kyoung-Nam ; Kim, Hwa Young ; Lim, Youn-Hee ; Shin, Choong Ho ; Kim, Johanna Inhyang ; Kim, Bung-Nyun ; Lee, Young Ah ; Hong, Yun-Chul. / Prenatal and early childhood phthalate exposures and thyroid function among school-age children. I: Environment International. 2020 ; Bind 141.

Bibtex

@article{a7790ef7e84f4f20b7eac5135f2ed5af,
title = "Prenatal and early childhood phthalate exposures and thyroid function among school-age children",
abstract = "BACKGROUND: Limited studies have investigated the association between prenatal and early childhood phthalate exposures and thyroid function among children.OBJECTIVES: To investigate the association between early life phthalate exposure and thyroid function among school-age children, considering both prenatal and early childhood exposures, using longitudinal data from an established prospective cohort.METHODS: We measured urinary phthalate metabolite levels during pregnancy and at 2, 4, and 6 years of age and conducted thyroid function tests at 6 years of age. We assessed the associations between phthalate metabolite levels and thyroid function using linear regression and Bayesian kernel machine regression (BKMR) models (n = 492).RESULTS: In linear regression models, a doubling of urinary mono-n-butyl phthalate (MnBP) levels, measured during pregnancy and at 4 years of age, was associated with lower thyroid-stimulating hormone (TSH) levels at 6 years of age (-5.0%, 95% confidence interval [CI]: -8.8%, -1.0% and -5.7%, 95% CI: -9.7%, -1.5%, respectively). A similar association was found between mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) levels at 4 years of age and TSH levels at 6 years of age (-5.5%, 95% CI: -9.7%, -1.1%). Urinary mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) (2.3%, 95% CI: 0.1%, 4.5%) and MEOHP levels at 2 years of age (2.2%, 95% CI: 0.1%, 4.4%) and mono-2-ethyl-5-carboxypentyl phthalate (1.4%, 95% CI: 0.1%, 2.7%) and mono-benzyl phthalate levels at 6 years of age (1.1%, 95% CI: 0.4%, 1.9%) were associated with higher triiodothyronine (T3) levels at 6 years of age. Urinary MnBP during pregnancy, MEHHP, MEOHP, and MnBP at 4 years of age were also associated with lower free thyroxine (fT4) × TSH. In BKMR models, urinary MnBP levels during pregnancy were associated with lower TSH levels and fT4 × TSH (both posterior inclusion probabilities: 0.99).CONCLUSIONS: Our findings suggest that early life phthalate exposure influences subsequent thyroid function. However, the results should be interpreted cautiously, because a single spot urine sample was used to quantify the phthalate exposures at each time point.",
author = "Kyoung-Nam Kim and Kim, {Hwa Young} and Youn-Hee Lim and Shin, {Choong Ho} and Kim, {Johanna Inhyang} and Bung-Nyun Kim and Lee, {Young Ah} and Yun-Chul Hong",
note = "Copyright {\textcopyright} 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2020",
doi = "10.1016/j.envint.2020.105782",
language = "English",
volume = "141",
journal = "Environment International",
issn = "0160-4120",
publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Prenatal and early childhood phthalate exposures and thyroid function among school-age children

AU - Kim, Kyoung-Nam

AU - Kim, Hwa Young

AU - Lim, Youn-Hee

AU - Shin, Choong Ho

AU - Kim, Johanna Inhyang

AU - Kim, Bung-Nyun

AU - Lee, Young Ah

AU - Hong, Yun-Chul

N1 - Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2020

Y1 - 2020

N2 - BACKGROUND: Limited studies have investigated the association between prenatal and early childhood phthalate exposures and thyroid function among children.OBJECTIVES: To investigate the association between early life phthalate exposure and thyroid function among school-age children, considering both prenatal and early childhood exposures, using longitudinal data from an established prospective cohort.METHODS: We measured urinary phthalate metabolite levels during pregnancy and at 2, 4, and 6 years of age and conducted thyroid function tests at 6 years of age. We assessed the associations between phthalate metabolite levels and thyroid function using linear regression and Bayesian kernel machine regression (BKMR) models (n = 492).RESULTS: In linear regression models, a doubling of urinary mono-n-butyl phthalate (MnBP) levels, measured during pregnancy and at 4 years of age, was associated with lower thyroid-stimulating hormone (TSH) levels at 6 years of age (-5.0%, 95% confidence interval [CI]: -8.8%, -1.0% and -5.7%, 95% CI: -9.7%, -1.5%, respectively). A similar association was found between mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) levels at 4 years of age and TSH levels at 6 years of age (-5.5%, 95% CI: -9.7%, -1.1%). Urinary mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) (2.3%, 95% CI: 0.1%, 4.5%) and MEOHP levels at 2 years of age (2.2%, 95% CI: 0.1%, 4.4%) and mono-2-ethyl-5-carboxypentyl phthalate (1.4%, 95% CI: 0.1%, 2.7%) and mono-benzyl phthalate levels at 6 years of age (1.1%, 95% CI: 0.4%, 1.9%) were associated with higher triiodothyronine (T3) levels at 6 years of age. Urinary MnBP during pregnancy, MEHHP, MEOHP, and MnBP at 4 years of age were also associated with lower free thyroxine (fT4) × TSH. In BKMR models, urinary MnBP levels during pregnancy were associated with lower TSH levels and fT4 × TSH (both posterior inclusion probabilities: 0.99).CONCLUSIONS: Our findings suggest that early life phthalate exposure influences subsequent thyroid function. However, the results should be interpreted cautiously, because a single spot urine sample was used to quantify the phthalate exposures at each time point.

AB - BACKGROUND: Limited studies have investigated the association between prenatal and early childhood phthalate exposures and thyroid function among children.OBJECTIVES: To investigate the association between early life phthalate exposure and thyroid function among school-age children, considering both prenatal and early childhood exposures, using longitudinal data from an established prospective cohort.METHODS: We measured urinary phthalate metabolite levels during pregnancy and at 2, 4, and 6 years of age and conducted thyroid function tests at 6 years of age. We assessed the associations between phthalate metabolite levels and thyroid function using linear regression and Bayesian kernel machine regression (BKMR) models (n = 492).RESULTS: In linear regression models, a doubling of urinary mono-n-butyl phthalate (MnBP) levels, measured during pregnancy and at 4 years of age, was associated with lower thyroid-stimulating hormone (TSH) levels at 6 years of age (-5.0%, 95% confidence interval [CI]: -8.8%, -1.0% and -5.7%, 95% CI: -9.7%, -1.5%, respectively). A similar association was found between mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) levels at 4 years of age and TSH levels at 6 years of age (-5.5%, 95% CI: -9.7%, -1.1%). Urinary mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) (2.3%, 95% CI: 0.1%, 4.5%) and MEOHP levels at 2 years of age (2.2%, 95% CI: 0.1%, 4.4%) and mono-2-ethyl-5-carboxypentyl phthalate (1.4%, 95% CI: 0.1%, 2.7%) and mono-benzyl phthalate levels at 6 years of age (1.1%, 95% CI: 0.4%, 1.9%) were associated with higher triiodothyronine (T3) levels at 6 years of age. Urinary MnBP during pregnancy, MEHHP, MEOHP, and MnBP at 4 years of age were also associated with lower free thyroxine (fT4) × TSH. In BKMR models, urinary MnBP levels during pregnancy were associated with lower TSH levels and fT4 × TSH (both posterior inclusion probabilities: 0.99).CONCLUSIONS: Our findings suggest that early life phthalate exposure influences subsequent thyroid function. However, the results should be interpreted cautiously, because a single spot urine sample was used to quantify the phthalate exposures at each time point.

U2 - 10.1016/j.envint.2020.105782

DO - 10.1016/j.envint.2020.105782

M3 - Journal article

C2 - 32450450

VL - 141

JO - Environment International

JF - Environment International

SN - 0160-4120

M1 - 105782

ER -

ID: 241877054