Potential exposure to endocrine disrupting chemicals and selected adverse pregnancy outcomes: a follow-up study of pregnant women referred for occupational counselling

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

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Potential exposure to endocrine disrupting chemicals and selected adverse pregnancy outcomes : a follow-up study of pregnant women referred for occupational counselling. / Bengtsson, Jessica; Thygesen, Pernille Søgaard; Kaerlev, Linda; Knudsen, Lisbeth E.; Bonde, Jens Peter.

I: Journal of Occupational Medicine and Toxicology (London), Bind 12, 6, 09.03.2017, s. 1-6.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Bengtsson, J, Thygesen, PS, Kaerlev, L, Knudsen, LE & Bonde, JP 2017, 'Potential exposure to endocrine disrupting chemicals and selected adverse pregnancy outcomes: a follow-up study of pregnant women referred for occupational counselling', Journal of Occupational Medicine and Toxicology (London), bind 12, 6, s. 1-6. https://doi.org/10.1186/s12995-017-0152-y

APA

Bengtsson, J., Thygesen, P. S., Kaerlev, L., Knudsen, L. E., & Bonde, J. P. (2017). Potential exposure to endocrine disrupting chemicals and selected adverse pregnancy outcomes: a follow-up study of pregnant women referred for occupational counselling. Journal of Occupational Medicine and Toxicology (London), 12, 1-6. [6]. https://doi.org/10.1186/s12995-017-0152-y

Vancouver

Bengtsson J, Thygesen PS, Kaerlev L, Knudsen LE, Bonde JP. Potential exposure to endocrine disrupting chemicals and selected adverse pregnancy outcomes: a follow-up study of pregnant women referred for occupational counselling. Journal of Occupational Medicine and Toxicology (London). 2017 mar. 9;12:1-6. 6. https://doi.org/10.1186/s12995-017-0152-y

Author

Bengtsson, Jessica ; Thygesen, Pernille Søgaard ; Kaerlev, Linda ; Knudsen, Lisbeth E. ; Bonde, Jens Peter. / Potential exposure to endocrine disrupting chemicals and selected adverse pregnancy outcomes : a follow-up study of pregnant women referred for occupational counselling. I: Journal of Occupational Medicine and Toxicology (London). 2017 ; Bind 12. s. 1-6.

Bibtex

@article{f8f33a9b5de84fde9ff655414f1f2b25,
title = "Potential exposure to endocrine disrupting chemicals and selected adverse pregnancy outcomes: a follow-up study of pregnant women referred for occupational counselling",
abstract = "Background: Experimental evidence indicates that fetal exposure to xenobiotics with the potential to interfere with the endogenous steroid hormone regulation of fetal development may reduce birth weight. However, epidemiological studies are limited. The aim of the study was to investigate whether potential occupational exposure to endocrine disrupting chemicals (EDC) of the mother during pregnancy is associated with preterm birth and low birth weight.Methods: Pregnant women referred to an Occupational Health Clinic (OHC) in two Danish regions (Copenhagen or Aarhus) between 1984 and 2010, suspected of being exposed to occupational reproductive hazards were included in the study. A job exposure matrix enabled estimation of potential occupational exposure to EDC on the basis of job title. Births by women potentially exposed to EDC (n = 582) were compared to births by women referred to an OHC on the suspicion of other exposures than EDC (n = 620), and to a sample of births by all occupationally active women in the same geographical regions (n = 346,544), including 1,077 births of the referred women{\textquoteright}s non-referred pregnancies.Results: No indications of reduced birth weight or increased risk of preterm birth were found among women potentially exposed to EDC. Women potentially exposed to EDC had children with a higher birth weight compared to the sample of occupationally active women but not compared to other women referred to an OHC.Conclusions: Potential maternal exposure to EDC at Danish workplaces is not related to low birth weight or preterm birth among women referred to occupational counselling. Occupational exposures might be too weak on the average to cause these adverse effects or counselling at the OHCs is effective in preventing them.",
keywords = "Endocrine disrupting chemicals, Birth weight, Gestational age, Job exposure matrix, Occupational health clinic, Work health, Prospective study, Epidemiology, Public health",
author = "Jessica Bengtsson and Thygesen, {Pernille S{\o}gaard} and Linda Kaerlev and Knudsen, {Lisbeth E.} and Bonde, {Jens Peter}",
year = "2017",
month = mar,
day = "9",
doi = "10.1186/s12995-017-0152-y",
language = "English",
volume = "12",
pages = "1--6",
journal = "Journal of Occupational Medicine and Toxicology",
issn = "1745-6673",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Potential exposure to endocrine disrupting chemicals and selected adverse pregnancy outcomes

T2 - a follow-up study of pregnant women referred for occupational counselling

AU - Bengtsson, Jessica

AU - Thygesen, Pernille Søgaard

AU - Kaerlev, Linda

AU - Knudsen, Lisbeth E.

AU - Bonde, Jens Peter

PY - 2017/3/9

Y1 - 2017/3/9

N2 - Background: Experimental evidence indicates that fetal exposure to xenobiotics with the potential to interfere with the endogenous steroid hormone regulation of fetal development may reduce birth weight. However, epidemiological studies are limited. The aim of the study was to investigate whether potential occupational exposure to endocrine disrupting chemicals (EDC) of the mother during pregnancy is associated with preterm birth and low birth weight.Methods: Pregnant women referred to an Occupational Health Clinic (OHC) in two Danish regions (Copenhagen or Aarhus) between 1984 and 2010, suspected of being exposed to occupational reproductive hazards were included in the study. A job exposure matrix enabled estimation of potential occupational exposure to EDC on the basis of job title. Births by women potentially exposed to EDC (n = 582) were compared to births by women referred to an OHC on the suspicion of other exposures than EDC (n = 620), and to a sample of births by all occupationally active women in the same geographical regions (n = 346,544), including 1,077 births of the referred women’s non-referred pregnancies.Results: No indications of reduced birth weight or increased risk of preterm birth were found among women potentially exposed to EDC. Women potentially exposed to EDC had children with a higher birth weight compared to the sample of occupationally active women but not compared to other women referred to an OHC.Conclusions: Potential maternal exposure to EDC at Danish workplaces is not related to low birth weight or preterm birth among women referred to occupational counselling. Occupational exposures might be too weak on the average to cause these adverse effects or counselling at the OHCs is effective in preventing them.

AB - Background: Experimental evidence indicates that fetal exposure to xenobiotics with the potential to interfere with the endogenous steroid hormone regulation of fetal development may reduce birth weight. However, epidemiological studies are limited. The aim of the study was to investigate whether potential occupational exposure to endocrine disrupting chemicals (EDC) of the mother during pregnancy is associated with preterm birth and low birth weight.Methods: Pregnant women referred to an Occupational Health Clinic (OHC) in two Danish regions (Copenhagen or Aarhus) between 1984 and 2010, suspected of being exposed to occupational reproductive hazards were included in the study. A job exposure matrix enabled estimation of potential occupational exposure to EDC on the basis of job title. Births by women potentially exposed to EDC (n = 582) were compared to births by women referred to an OHC on the suspicion of other exposures than EDC (n = 620), and to a sample of births by all occupationally active women in the same geographical regions (n = 346,544), including 1,077 births of the referred women’s non-referred pregnancies.Results: No indications of reduced birth weight or increased risk of preterm birth were found among women potentially exposed to EDC. Women potentially exposed to EDC had children with a higher birth weight compared to the sample of occupationally active women but not compared to other women referred to an OHC.Conclusions: Potential maternal exposure to EDC at Danish workplaces is not related to low birth weight or preterm birth among women referred to occupational counselling. Occupational exposures might be too weak on the average to cause these adverse effects or counselling at the OHCs is effective in preventing them.

KW - Endocrine disrupting chemicals

KW - Birth weight

KW - Gestational age

KW - Job exposure matrix

KW - Occupational health clinic

KW - Work health

KW - Prospective study

KW - Epidemiology

KW - Public health

U2 - 10.1186/s12995-017-0152-y

DO - 10.1186/s12995-017-0152-y

M3 - Journal article

C2 - 28286539

VL - 12

SP - 1

EP - 6

JO - Journal of Occupational Medicine and Toxicology

JF - Journal of Occupational Medicine and Toxicology

SN - 1745-6673

M1 - 6

ER -

ID: 180576902