Potassium Channels in the Heart

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

Standard

Potassium Channels in the Heart. / Thomsen, Morten B.

Cardiac and Vascular Biology. Springer Science and Business Media Deutschland GmbH, 2018. s. 47-75 (Cardiac and Vascular Biology, Bind 6).

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

Harvard

Thomsen, MB 2018, Potassium Channels in the Heart. i Cardiac and Vascular Biology. Springer Science and Business Media Deutschland GmbH, Cardiac and Vascular Biology, bind 6, s. 47-75. https://doi.org/10.1007/978-3-319-77812-9_3

APA

Thomsen, M. B. (2018). Potassium Channels in the Heart. I Cardiac and Vascular Biology (s. 47-75). Springer Science and Business Media Deutschland GmbH. Cardiac and Vascular Biology Bind 6 https://doi.org/10.1007/978-3-319-77812-9_3

Vancouver

Thomsen MB. Potassium Channels in the Heart. I Cardiac and Vascular Biology. Springer Science and Business Media Deutschland GmbH. 2018. s. 47-75. (Cardiac and Vascular Biology, Bind 6). https://doi.org/10.1007/978-3-319-77812-9_3

Author

Thomsen, Morten B. / Potassium Channels in the Heart. Cardiac and Vascular Biology. Springer Science and Business Media Deutschland GmbH, 2018. s. 47-75 (Cardiac and Vascular Biology, Bind 6).

Bibtex

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title = "Potassium Channels in the Heart",
abstract = "Ionic currents over the plasma membrane through channels are the cornerstone of excitable cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized and a repolarized state every second throughout human life, initiating and coordinating cardiac pump function. Ion channels selective for potassium (K+) critically participate in cellular repolarization and contribute to stabilizing the diastolic membrane potential, thus shaping the cardiac action potential. Four different subfamilies of potassium channels are present in the heart: small conductance, calcium-activated potassium channels (SK or KCa2), inwardly rectifying potassium channels (Kir), two-pore-domain potassium channels (K2P), and voltage-gated potassium channels (KV). In the present review, the structure and biophysical function of these cardiac potassium ion channels are reviewed. Moreover, rectification, inactivation, and current dependency on the extracellular potassium concentration are explained.",
author = "Thomsen, {Morten B.}",
note = "Publisher Copyright: {\textcopyright} 2018, Springer International Publishing AG, part of Springer Nature.",
year = "2018",
doi = "10.1007/978-3-319-77812-9_3",
language = "English",
series = "Cardiac and Vascular Biology",
publisher = "Springer Science and Business Media Deutschland GmbH",
pages = "47--75",
booktitle = "Cardiac and Vascular Biology",
address = "Germany",

}

RIS

TY - CHAP

T1 - Potassium Channels in the Heart

AU - Thomsen, Morten B.

N1 - Publisher Copyright: © 2018, Springer International Publishing AG, part of Springer Nature.

PY - 2018

Y1 - 2018

N2 - Ionic currents over the plasma membrane through channels are the cornerstone of excitable cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized and a repolarized state every second throughout human life, initiating and coordinating cardiac pump function. Ion channels selective for potassium (K+) critically participate in cellular repolarization and contribute to stabilizing the diastolic membrane potential, thus shaping the cardiac action potential. Four different subfamilies of potassium channels are present in the heart: small conductance, calcium-activated potassium channels (SK or KCa2), inwardly rectifying potassium channels (Kir), two-pore-domain potassium channels (K2P), and voltage-gated potassium channels (KV). In the present review, the structure and biophysical function of these cardiac potassium ion channels are reviewed. Moreover, rectification, inactivation, and current dependency on the extracellular potassium concentration are explained.

AB - Ionic currents over the plasma membrane through channels are the cornerstone of excitable cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized and a repolarized state every second throughout human life, initiating and coordinating cardiac pump function. Ion channels selective for potassium (K+) critically participate in cellular repolarization and contribute to stabilizing the diastolic membrane potential, thus shaping the cardiac action potential. Four different subfamilies of potassium channels are present in the heart: small conductance, calcium-activated potassium channels (SK or KCa2), inwardly rectifying potassium channels (Kir), two-pore-domain potassium channels (K2P), and voltage-gated potassium channels (KV). In the present review, the structure and biophysical function of these cardiac potassium ion channels are reviewed. Moreover, rectification, inactivation, and current dependency on the extracellular potassium concentration are explained.

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U2 - 10.1007/978-3-319-77812-9_3

DO - 10.1007/978-3-319-77812-9_3

M3 - Book chapter

AN - SCOPUS:85102585634

T3 - Cardiac and Vascular Biology

SP - 47

EP - 75

BT - Cardiac and Vascular Biology

PB - Springer Science and Business Media Deutschland GmbH

ER -

ID: 272642328