Potassium channels in the heart

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologi

Ionic currents over the plasma membrane through channels are the cornerstone of excitable cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized and a repolarized state every second throughout human life, initiating and coordinating cardiac pump function. Ion channels selective for potassium (K+) critically participate in cellular repolarization and contribute to stabilizing the diastolic membrane potential, thus shaping the cardiac action potential. Four different subfamilies of potassium channels are present in the heart: small conductance, calcium-activated potassium channels (SK or K-Ca(2)), inwardly rectifying potassium channels (K-ir), two-pore-domain potassium channels (K-2P), and voltage-gated potassium channels (K-V). In the present review, the structure and biophysical function of these cardiac potassium ion channels are reviewed. Moreover, rectification, inactivation, and current dependency on the extracellular potassium concentration are explained.
OriginalsprogEngelsk
TitelChannelopathies in Heart Disease
RedaktørerDierk Thomas , Carol Ann Remme
ForlagSpringer
Publikationsdato2018
Sider47-75
ISBN (Trykt)978-3-319-77811-2
ISBN (Elektronisk) 978-3-319-77812-9
DOI
StatusUdgivet - 2018
NavnCardiac and Vascular Biology

ID: 210151234