Potassium channels in the heart
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Potassium channels in the heart. / Thomsen, Morten Bækgaard.
Channelopathies in Heart Disease. red. / Dierk Thomas ; Carol Ann Remme. Springer, 2018. s. 47-75 (Cardiac and Vascular Biology, Bind 6).Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - Potassium channels in the heart
AU - Thomsen, Morten Bækgaard
N1 - Publisher Copyright: © 2018, Springer International Publishing AG, part of Springer Nature.
PY - 2018
Y1 - 2018
N2 - Ionic currents over the plasma membrane through channels are the cornerstone of excitable cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized and a repolarized state every second throughout human life, initiating and coordinating cardiac pump function. Ion channels selective for potassium (K+) critically participate in cellular repolarization and contribute to stabilizing the diastolic membrane potential, thus shaping the cardiac action potential. Four different subfamilies of potassium channels are present in the heart: small conductance, calcium-activated potassium channels (SK or KCa2), inwardly rectifying potassium channels (Kir), two-pore-domain potassium channels (K2P), and voltage-gated potassium channels (KV). In the present review, the structure and biophysical function of these cardiac potassium ion channels are reviewed. Moreover, rectification, inactivation, and current dependency on the extracellular potassium concentration are explained.
AB - Ionic currents over the plasma membrane through channels are the cornerstone of excitable cells. Human cardiomyocytes are excitable and continuously cycle between a depolarized and a repolarized state every second throughout human life, initiating and coordinating cardiac pump function. Ion channels selective for potassium (K+) critically participate in cellular repolarization and contribute to stabilizing the diastolic membrane potential, thus shaping the cardiac action potential. Four different subfamilies of potassium channels are present in the heart: small conductance, calcium-activated potassium channels (SK or KCa2), inwardly rectifying potassium channels (Kir), two-pore-domain potassium channels (K2P), and voltage-gated potassium channels (KV). In the present review, the structure and biophysical function of these cardiac potassium ion channels are reviewed. Moreover, rectification, inactivation, and current dependency on the extracellular potassium concentration are explained.
U2 - 10.1007/978-3-319-77812-9_3
DO - 10.1007/978-3-319-77812-9_3
M3 - Book chapter
AN - SCOPUS:85102585634
SN - 978-3-319-77811-2
T3 - Cardiac and Vascular Biology
SP - 47
EP - 75
BT - Channelopathies in Heart Disease
A2 - Thomas , Dierk
A2 - Remme, Carol Ann
PB - Springer
ER -
ID: 210151234