Perivascular spaces, glymphatic dysfunction, and small vessel disease
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Perivascular spaces, glymphatic dysfunction, and small vessel disease. / Mestre, Humberto; Kostrikov, Serhii; Mehta, Rupal I.; Nedergaard, Maiken.
I: Clinical Science, Bind 131, Nr. 17, 01.09.2017, s. 2257-2274.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Perivascular spaces, glymphatic dysfunction, and small vessel disease
AU - Mestre, Humberto
AU - Kostrikov, Serhii
AU - Mehta, Rupal I.
AU - Nedergaard, Maiken
N1 - © 2017 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Cerebral small vessel diseases (SVDs) range broadly in etiology but share remarkably overlapping pathology. Features of SVD including enlarged perivascular spaces (EPVS) and formation of abluminal protein deposits cannot be completely explained by the putative pathophysiology. The recently discovered glymphatic system provides a new perspective to potentially address these gaps. This work provides a comprehensive review of the known factors that regulate glymphatic function and the disease mechanisms underlying glymphatic impairment emphasizing the role that aquaporin-4 (AQP4)-lined perivascular spaces (PVSs), cerebrovascular pulsatility, and metabolite clearance play in normal CNS physiology. This review also discusses the implications that glymphatic impairment may have on SVD inception and progression with the aim of exploring novel therapeutic targets and highlighting the key questions that remain to be answered.
AB - Cerebral small vessel diseases (SVDs) range broadly in etiology but share remarkably overlapping pathology. Features of SVD including enlarged perivascular spaces (EPVS) and formation of abluminal protein deposits cannot be completely explained by the putative pathophysiology. The recently discovered glymphatic system provides a new perspective to potentially address these gaps. This work provides a comprehensive review of the known factors that regulate glymphatic function and the disease mechanisms underlying glymphatic impairment emphasizing the role that aquaporin-4 (AQP4)-lined perivascular spaces (PVSs), cerebrovascular pulsatility, and metabolite clearance play in normal CNS physiology. This review also discusses the implications that glymphatic impairment may have on SVD inception and progression with the aim of exploring novel therapeutic targets and highlighting the key questions that remain to be answered.
KW - Animals
KW - Aquaporin 4
KW - Blood Vessels
KW - Brain
KW - Cerebral Small Vessel Diseases
KW - Humans
KW - Journal Article
KW - Review
U2 - 10.1042/CS20160381
DO - 10.1042/CS20160381
M3 - Review
C2 - 28798076
VL - 131
SP - 2257
EP - 2274
JO - Clinical Science
JF - Clinical Science
SN - 0143-5221
IS - 17
ER -
ID: 185945302