Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes
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Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes. / Magnus, Maria C; Olsen, Sjurdur F.; Granstrom, Charlotta; Lund-Blix, Nicolai A; Svensson, Jannet; Johannesen, Jesper; Fraser, Abigail; Skrivarhaug, Torild; Joner, Geir; Njølstad, Pål R; Størdal, Ketil; Stene, Lars C.
I: International Journal of Epidemiology, Bind 47, Nr. 2, 2018, s. 417-426.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes
AU - Magnus, Maria C
AU - Olsen, Sjurdur F.
AU - Granstrom, Charlotta
AU - Lund-Blix, Nicolai A
AU - Svensson, Jannet
AU - Johannesen, Jesper
AU - Fraser, Abigail
AU - Skrivarhaug, Torild
AU - Joner, Geir
AU - Njølstad, Pål R
AU - Størdal, Ketil
AU - Stene, Lars C
PY - 2018
Y1 - 2018
N2 - Background: Our objective was to examine the associations of parental body mass index (BMI) and maternal gestational weight gain with childhood-onset type 1 diabetes. Comparing the associations of maternal and paternal BMI with type 1 diabetes in the offspring will provide further insight into the role of unmeasured confounding by characteristics linked to BMI in both parents.Methods: We studied 132 331 children participating in the Norwegian Mother and Child Cohort Study (MoBa) and the Danish National Birth Cohort (DNBC) who were born between February 1998 and July 2009. Exposures of interest included parental BMI and maternal gestational weight gain obtained by maternal report. We used Cox-proportional hazards regression to examine the risk of type 1 diabetes (n=499 cases), which was ascertained by national childhood diabetes registers.Results: The incidence of type 1 diabetes was 32.7 per 100 000 person-years in MoBa and 28.5 per 100 000 person-years in DNBC. Both maternal pre-pregnancy obesity, adjusted hazard ratio (HR) 1.41 [95% confidence interval (CI): 1.06, 1.89] and paternal obesity, adjusted HR 1.51 (95% CI: 1.11, 2.04), were associated with childhood-onset type 1 diabetes. The associations were similar after mutual adjustment. In contrast, maternal total gestational weight gain was not associated with childhood-onset type 1 diabetes, adjusted HR 1.00 (95% CI: 0.99, 1.02) per kilogram increase.Conclusions: Our study suggests that the association between maternal obesity and childhood-onset type 1 diabetes is not likely explained by intrauterine mechanisms, but possibly rather by unknown environmental factors influencing BMI in the family.
AB - Background: Our objective was to examine the associations of parental body mass index (BMI) and maternal gestational weight gain with childhood-onset type 1 diabetes. Comparing the associations of maternal and paternal BMI with type 1 diabetes in the offspring will provide further insight into the role of unmeasured confounding by characteristics linked to BMI in both parents.Methods: We studied 132 331 children participating in the Norwegian Mother and Child Cohort Study (MoBa) and the Danish National Birth Cohort (DNBC) who were born between February 1998 and July 2009. Exposures of interest included parental BMI and maternal gestational weight gain obtained by maternal report. We used Cox-proportional hazards regression to examine the risk of type 1 diabetes (n=499 cases), which was ascertained by national childhood diabetes registers.Results: The incidence of type 1 diabetes was 32.7 per 100 000 person-years in MoBa and 28.5 per 100 000 person-years in DNBC. Both maternal pre-pregnancy obesity, adjusted hazard ratio (HR) 1.41 [95% confidence interval (CI): 1.06, 1.89] and paternal obesity, adjusted HR 1.51 (95% CI: 1.11, 2.04), were associated with childhood-onset type 1 diabetes. The associations were similar after mutual adjustment. In contrast, maternal total gestational weight gain was not associated with childhood-onset type 1 diabetes, adjusted HR 1.00 (95% CI: 0.99, 1.02) per kilogram increase.Conclusions: Our study suggests that the association between maternal obesity and childhood-onset type 1 diabetes is not likely explained by intrauterine mechanisms, but possibly rather by unknown environmental factors influencing BMI in the family.
KW - Adolescent
KW - Adult
KW - Body Mass Index
KW - Child
KW - Cohort Studies
KW - Denmark/epidemiology
KW - Diabetes Mellitus, Type 1/epidemiology
KW - Female
KW - Gestational Weight Gain
KW - Humans
KW - Incidence
KW - Male
KW - Norway/epidemiology
KW - Obesity/epidemiology
KW - Parents
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects
KW - Proportional Hazards Models
KW - Risk Factors
KW - Young Adult
U2 - 10.1093/ije/dyx266
DO - 10.1093/ije/dyx266
M3 - Journal article
C2 - 29415279
VL - 47
SP - 417
EP - 426
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
SN - 0300-5771
IS - 2
ER -
ID: 215239644