Oxyntomodulin and glicentin may predict the effect of bariatric surgery on food preferences and weight loss

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Standard

Oxyntomodulin and glicentin may predict the effect of bariatric surgery on food preferences and weight loss. / Nielsen, Mette Søndergaard; Ritz, Christian; Albrechtsen, Nicolai Jacob Wewer; Holst, Jens Juul; le Roux, Carel W; Sjödin, Anders Mikael.

I: Journal of Clinical Endocrinology and Metabolism, Bind 105, Nr. 4, 2020, s. e1064-e1074.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Nielsen, MS, Ritz, C, Albrechtsen, NJW, Holst, JJ, le Roux, CW & Sjödin, AM 2020, 'Oxyntomodulin and glicentin may predict the effect of bariatric surgery on food preferences and weight loss', Journal of Clinical Endocrinology and Metabolism, bind 105, nr. 4, s. e1064-e1074. https://doi.org/10.1210/clinem/dgaa061

APA

Nielsen, M. S., Ritz, C., Albrechtsen, N. J. W., Holst, J. J., le Roux, C. W., & Sjödin, A. M. (2020). Oxyntomodulin and glicentin may predict the effect of bariatric surgery on food preferences and weight loss. Journal of Clinical Endocrinology and Metabolism, 105(4), e1064-e1074. https://doi.org/10.1210/clinem/dgaa061

Vancouver

Nielsen MS, Ritz C, Albrechtsen NJW, Holst JJ, le Roux CW, Sjödin AM. Oxyntomodulin and glicentin may predict the effect of bariatric surgery on food preferences and weight loss. Journal of Clinical Endocrinology and Metabolism. 2020;105(4):e1064-e1074. https://doi.org/10.1210/clinem/dgaa061

Author

Nielsen, Mette Søndergaard ; Ritz, Christian ; Albrechtsen, Nicolai Jacob Wewer ; Holst, Jens Juul ; le Roux, Carel W ; Sjödin, Anders Mikael. / Oxyntomodulin and glicentin may predict the effect of bariatric surgery on food preferences and weight loss. I: Journal of Clinical Endocrinology and Metabolism. 2020 ; Bind 105, Nr. 4. s. e1064-e1074.

Bibtex

@article{d2068859aacb4eceb33c992205ea2f6e,
title = "Oxyntomodulin and glicentin may predict the effect of bariatric surgery on food preferences and weight loss",
abstract = "Background: Alterations in several gastrointestinal hormones are implicated in the postoperative suppression of food intake leading to weight loss after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). The aim was to evaluate changes in responses of gastrointestinal hormones after RYGB and SG and the associations of these changes with weight loss, energy intake, and food preferences.Methods: Forty-two subjects with severe obesity were included (32 RYGB; 10 SG). Postprandial responses of glicentin, oxyntomodulin, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and ghrelin were measured before and 6 months after surgery. Energy intake and energy density were assessed before and 6 months after surgery using a buffet meal test and weight loss was assessed 18 months after surgery.Results: Postprandial concentrations of glicentin, oxyntomodulin, GLP-1, and ghrelin differed between RYGB and SG (all P ≤ .02). Enhanced responses of glicentin and oxyntomodulin predicted a greater weight loss (both P < .01) and were associated with a larger decrease in energy density (P ≤ .04). No associations were found for GLP-1, PYY, and ghrelin, and changes were not associated with changes in energy intake. When combing all hormones, 60{\%}, 19{\%}, and 33{\%} of the variations in weight loss, energy intake, and energy density, respectively, could be explained.Conclusion: Postprandial responses of gastrointestinal hormones differed between RYGB and SG. Enhanced responses of glicentin and oxyntomodulin predicted a better weight loss and were associated with a decreased preference for energy-dense foods. Replication of these results could imply an opportunity to identify patients in need of additional support after surgical treatments of obesity.",
keywords = "Faculty of Science, Gut hormones, Predictors, Bariatric surgery",
author = "Nielsen, {Mette S{\o}ndergaard} and Christian Ritz and Albrechtsen, {Nicolai Jacob Wewer} and Holst, {Jens Juul} and {le Roux}, {Carel W} and Sj{\"o}din, {Anders Mikael}",
note = "{\circledC} Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.",
year = "2020",
doi = "10.1210/clinem/dgaa061",
language = "English",
volume = "105",
pages = "e1064--e1074",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Oxyntomodulin and glicentin may predict the effect of bariatric surgery on food preferences and weight loss

AU - Nielsen, Mette Søndergaard

AU - Ritz, Christian

AU - Albrechtsen, Nicolai Jacob Wewer

AU - Holst, Jens Juul

AU - le Roux, Carel W

AU - Sjödin, Anders Mikael

N1 - © Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

PY - 2020

Y1 - 2020

N2 - Background: Alterations in several gastrointestinal hormones are implicated in the postoperative suppression of food intake leading to weight loss after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). The aim was to evaluate changes in responses of gastrointestinal hormones after RYGB and SG and the associations of these changes with weight loss, energy intake, and food preferences.Methods: Forty-two subjects with severe obesity were included (32 RYGB; 10 SG). Postprandial responses of glicentin, oxyntomodulin, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and ghrelin were measured before and 6 months after surgery. Energy intake and energy density were assessed before and 6 months after surgery using a buffet meal test and weight loss was assessed 18 months after surgery.Results: Postprandial concentrations of glicentin, oxyntomodulin, GLP-1, and ghrelin differed between RYGB and SG (all P ≤ .02). Enhanced responses of glicentin and oxyntomodulin predicted a greater weight loss (both P < .01) and were associated with a larger decrease in energy density (P ≤ .04). No associations were found for GLP-1, PYY, and ghrelin, and changes were not associated with changes in energy intake. When combing all hormones, 60%, 19%, and 33% of the variations in weight loss, energy intake, and energy density, respectively, could be explained.Conclusion: Postprandial responses of gastrointestinal hormones differed between RYGB and SG. Enhanced responses of glicentin and oxyntomodulin predicted a better weight loss and were associated with a decreased preference for energy-dense foods. Replication of these results could imply an opportunity to identify patients in need of additional support after surgical treatments of obesity.

AB - Background: Alterations in several gastrointestinal hormones are implicated in the postoperative suppression of food intake leading to weight loss after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG). The aim was to evaluate changes in responses of gastrointestinal hormones after RYGB and SG and the associations of these changes with weight loss, energy intake, and food preferences.Methods: Forty-two subjects with severe obesity were included (32 RYGB; 10 SG). Postprandial responses of glicentin, oxyntomodulin, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), and ghrelin were measured before and 6 months after surgery. Energy intake and energy density were assessed before and 6 months after surgery using a buffet meal test and weight loss was assessed 18 months after surgery.Results: Postprandial concentrations of glicentin, oxyntomodulin, GLP-1, and ghrelin differed between RYGB and SG (all P ≤ .02). Enhanced responses of glicentin and oxyntomodulin predicted a greater weight loss (both P < .01) and were associated with a larger decrease in energy density (P ≤ .04). No associations were found for GLP-1, PYY, and ghrelin, and changes were not associated with changes in energy intake. When combing all hormones, 60%, 19%, and 33% of the variations in weight loss, energy intake, and energy density, respectively, could be explained.Conclusion: Postprandial responses of gastrointestinal hormones differed between RYGB and SG. Enhanced responses of glicentin and oxyntomodulin predicted a better weight loss and were associated with a decreased preference for energy-dense foods. Replication of these results could imply an opportunity to identify patients in need of additional support after surgical treatments of obesity.

KW - Faculty of Science

KW - Gut hormones

KW - Predictors

KW - Bariatric surgery

U2 - 10.1210/clinem/dgaa061

DO - 10.1210/clinem/dgaa061

M3 - Journal article

C2 - 32016415

VL - 105

SP - e1064-e1074

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 4

ER -

ID: 237757832