No effect of resveratrol on fatty acid oxidation or exercise capacity in patients with fatty acid oxidation disorders: A randomized clinical cross-over trial

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  • Jesper H. Storgaard
  • Nicoline Løkken
  • Karen L. Madsen
  • Nicol C. Voermans
  • Pascal Laforêt
  • Aleksandra Nadaj-Pakleza
  • Céline Tard
  • van Hall, Gerrit
  • Vissing, John
  • Mette C. Ørngreen

The objective was to investigate whether resveratrol (RSV) can improve exercise capacity in patients with fatty acid oxidation (FAO) disorders. The study was a randomized, double-blind, cross-over trial. Nine patients with very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency or carnitine palmitoyl transferase (CPT) II deficiency were randomized to receive either 8 weeks of 1000 mg day−1 RSV or placebo (P) followed by a 4-weeks wash-out period and subsequently 8 weeks of the opposite treatment. Primary outcome measures were heart rate and FAO as measured via stable isotope technique during constant workload exercise. Secondary outcome measures included fat and glucose metabolism; perceived exertion; as well as subjective measures of energy expenditure, fatigue, and daily function. Eight participants completed the trial. Heart rate did not differ at the end of exercise after treatment with RSV vs placebo (P =.063). Rate of oxidation of palmitate at end of exercise was not different with 1.5 ± 0.8 (RSV) vs 1.3 ± 0.6 (P) μmol kg−1 min−1 (P =.109). Secondary outcomes did not change except for increased plasma glycerol and decreased plasma glucose levels at the end of exercise after treatment with RSV vs placebo. A daily dose of 1000 mg resveratrol does not improve exercise capacity or FAO during exercise in patients with CPTII or VLCAD deficiencies.

OriginalsprogEngelsk
TidsskriftJournal of Inherited Metabolic Disease
Vol/bind45
Udgave nummer3
Sider (fra-til)517-528
ISSN0141-8955
DOI
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
The study was investigator‐driven. Both RSV and placebo capsules were provided by Evolva. This research was funded by Aase og Ejnar Danielsens Fond (grant number: 18‐10‐0350), Novo Nordisk Fonden (grant number: NNF17OC0027164), Grosserer L. F. Foghts Fond (grant number: 21.383), and Jascha Fonden (grant number: 7715). The authors confirm independence from the sponsors; the content of the article has not been influenced by the sponsors.

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© 2022 SSIEM.

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