New Parvovirus Associated with Serum Hepatitis in Horses after Inoculation of Common Biological Product
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Equine serum hepatitis (i.e., Theiler's disease) is a serious and often life-threatening disease of unknown etiology that affects horses. A horse in Nebraska, USA, with serum hepatitis died 65 days after treatment with equine-origin tetanus antitoxin. We identified an unknown parvovirus in serum and liver of the dead horse and in the administered antitoxin. The equine parvovirus-hepatitis (EqPV-H) shares <50% protein identity with its phylogenetic relatives of the genus Copiparvovirus. Next, we experimentally infected 2 horses using a tetanus antitoxin contaminated with EqPV-H. Viremia developed, the horses seroconverted, and acute hepatitis developed that was confirmed by clinical, biochemical, and histopathologic testing. We also determined that EqPV-H is an endemic infection because, in a cohort of 100 clinically normal adult horses, 13 were viremic and 15 were seropositive. We identified a new virus associated with equine serum hepatitis and confirmed its pathogenicity and transmissibility through contaminated biological products.
Originalsprog | Engelsk |
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Tidsskrift | Emerging Infectious Diseases |
Vol/bind | 24 |
Udgave nummer | 2 |
Sider (fra-til) | 303-310 |
Antal sider | 8 |
ISSN | 1080-6040 |
DOI | |
Status | Udgivet - feb. 2018 |
ID: 195496116