New descriptors of T-wave morphology are independent of heart rate

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Standard

New descriptors of T-wave morphology are independent of heart rate. / Andersen, Mads Peter; Xue, Joel Q; Graff, Claus; Kanters, Jørgen K.; Toft, Egon; Struijk, Johannes J.

I: Journal of Electrocardiology, Bind 41, Nr. 6, 2008, s. 557-61.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Andersen, MP, Xue, JQ, Graff, C, Kanters, JK, Toft, E & Struijk, JJ 2008, 'New descriptors of T-wave morphology are independent of heart rate', Journal of Electrocardiology, bind 41, nr. 6, s. 557-61. https://doi.org/10.1016/j.jelectrocard.2008.07.021

APA

Andersen, M. P., Xue, J. Q., Graff, C., Kanters, J. K., Toft, E., & Struijk, J. J. (2008). New descriptors of T-wave morphology are independent of heart rate. Journal of Electrocardiology, 41(6), 557-61. https://doi.org/10.1016/j.jelectrocard.2008.07.021

Vancouver

Andersen MP, Xue JQ, Graff C, Kanters JK, Toft E, Struijk JJ. New descriptors of T-wave morphology are independent of heart rate. Journal of Electrocardiology. 2008;41(6):557-61. https://doi.org/10.1016/j.jelectrocard.2008.07.021

Author

Andersen, Mads Peter ; Xue, Joel Q ; Graff, Claus ; Kanters, Jørgen K. ; Toft, Egon ; Struijk, Johannes J. / New descriptors of T-wave morphology are independent of heart rate. I: Journal of Electrocardiology. 2008 ; Bind 41, Nr. 6. s. 557-61.

Bibtex

@article{b067de687f2c430dbb8b579b79cf4b05,

title = "New descriptors of T-wave morphology are independent of heart rate",

abstract = "T-wave morphology descriptors are sensitive to drug-induced changes and may be a useful addition to the QT interval in cardiac safety trials. Intrasubject heart rate dependence of T-wave morphology was investigated in a sample of 39 healthy individuals. Ten-second electrocardiograms were obtained from daytime Holter recordings. Duration parameters (QT, ToTe, TpTe, and others), a number of basic T-wave morphology parameters (amplitude, area, and others) as well as advanced morphology descriptors (asymmetry, flatness, and others) were measured automatically. Heart rate dependence was examined by means of analysis of covariance. The results showed clear heart rate dependence for the QT interval (R(2) = 0.53-0.57) and a moderate degree of heart rate dependence for the basic morphology parameters (amplitude, area, and others) (R(2) = 0.17-0.42). Both the advanced T-wave descriptors (asymmetry, flatness, and others), ToTe intervals and TpTe intervals, were practically independent of heart rate (R(2) = 0-0.08), making heart rate correction unnecessary for these parameters.",

keywords = "Algorithms, Artifacts, Diagnosis, Computer-Assisted, Electrocardiography, Heart Rate, Humans, Pattern Recognition, Automated, Reproducibility of Results, Sensitivity and Specificity",

author = "Andersen, {Mads Peter} and Xue, {Joel Q} and Claus Graff and Kanters, {J{\o}rgen K.} and Egon Toft and Struijk, {Johannes J.}",

year = "2008",

doi = "10.1016/j.jelectrocard.2008.07.021",

language = "English",

volume = "41",

pages = "557--61",

journal = "Journal of Electrocardiology",

issn = "0022-0736",

publisher = "Churchill Livingstone",

number = "6",

}

RIS

TY - JOUR

T1 - New descriptors of T-wave morphology are independent of heart rate

AU - Andersen, Mads Peter

AU - Xue, Joel Q

AU - Graff, Claus

AU - Kanters, Jørgen K.

AU - Toft, Egon

AU - Struijk, Johannes J.

PY - 2008

Y1 - 2008

N2 - T-wave morphology descriptors are sensitive to drug-induced changes and may be a useful addition to the QT interval in cardiac safety trials. Intrasubject heart rate dependence of T-wave morphology was investigated in a sample of 39 healthy individuals. Ten-second electrocardiograms were obtained from daytime Holter recordings. Duration parameters (QT, ToTe, TpTe, and others), a number of basic T-wave morphology parameters (amplitude, area, and others) as well as advanced morphology descriptors (asymmetry, flatness, and others) were measured automatically. Heart rate dependence was examined by means of analysis of covariance. The results showed clear heart rate dependence for the QT interval (R(2) = 0.53-0.57) and a moderate degree of heart rate dependence for the basic morphology parameters (amplitude, area, and others) (R(2) = 0.17-0.42). Both the advanced T-wave descriptors (asymmetry, flatness, and others), ToTe intervals and TpTe intervals, were practically independent of heart rate (R(2) = 0-0.08), making heart rate correction unnecessary for these parameters.

AB - T-wave morphology descriptors are sensitive to drug-induced changes and may be a useful addition to the QT interval in cardiac safety trials. Intrasubject heart rate dependence of T-wave morphology was investigated in a sample of 39 healthy individuals. Ten-second electrocardiograms were obtained from daytime Holter recordings. Duration parameters (QT, ToTe, TpTe, and others), a number of basic T-wave morphology parameters (amplitude, area, and others) as well as advanced morphology descriptors (asymmetry, flatness, and others) were measured automatically. Heart rate dependence was examined by means of analysis of covariance. The results showed clear heart rate dependence for the QT interval (R(2) = 0.53-0.57) and a moderate degree of heart rate dependence for the basic morphology parameters (amplitude, area, and others) (R(2) = 0.17-0.42). Both the advanced T-wave descriptors (asymmetry, flatness, and others), ToTe intervals and TpTe intervals, were practically independent of heart rate (R(2) = 0-0.08), making heart rate correction unnecessary for these parameters.

KW - Algorithms

KW - Artifacts

KW - Diagnosis, Computer-Assisted

KW - Electrocardiography

KW - Heart Rate

KW - Humans

KW - Pattern Recognition, Automated

KW - Reproducibility of Results

KW - Sensitivity and Specificity

U2 - 10.1016/j.jelectrocard.2008.07.021

DO - 10.1016/j.jelectrocard.2008.07.021

M3 - Journal article

C2 - 18804787

VL - 41

SP - 557

EP - 561

JO - Journal of Electrocardiology

JF - Journal of Electrocardiology

SN - 0022-0736

IS - 6

ER -

ID: 33911254