Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice

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Standard

Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice. / Jögi, Annika; Rønø, Birgitte; Lund, Ida K; Nielsen, Boye S; Ploug, Michael; Høyer-Hansen, Gunilla; Rømer, John; Lund, Leif R.

I: P L o S One, Bind 5, Nr. 9, 01.09.2010, s. e12746.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jögi, A, Rønø, B, Lund, IK, Nielsen, BS, Ploug, M, Høyer-Hansen, G, Rømer, J & Lund, LR 2010, 'Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice', P L o S One, bind 5, nr. 9, s. e12746. https://doi.org/10.1371/journal.pone.0012746

APA

Jögi, A., Rønø, B., Lund, I. K., Nielsen, B. S., Ploug, M., Høyer-Hansen, G., Rømer, J., & Lund, L. R. (2010). Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice. P L o S One, 5(9), e12746. https://doi.org/10.1371/journal.pone.0012746

Vancouver

Jögi A, Rønø B, Lund IK, Nielsen BS, Ploug M, Høyer-Hansen G o.a. Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice. P L o S One. 2010 sep. 1;5(9):e12746. https://doi.org/10.1371/journal.pone.0012746

Author

Jögi, Annika ; Rønø, Birgitte ; Lund, Ida K ; Nielsen, Boye S ; Ploug, Michael ; Høyer-Hansen, Gunilla ; Rømer, John ; Lund, Leif R. / Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice. I: P L o S One. 2010 ; Bind 5, Nr. 9. s. e12746.

Bibtex

@article{4d039f635bf0469e814bbf5b8fdd48ee,

title = "Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice",

abstract = "Proteolytic degradation by plasmin and metalloproteinases is essential for epidermal regeneration in skin wound healing. Plasminogen deficient mice have severely delayed wound closure as have mice simultaneously lacking the two plasminogen activators, urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA). In contrast, individual genetic deficiencies in either uPA or tPA lead to wound healing kinetics with no or only slightly delayed closure of skin wounds.",

keywords = "Animals, Antibodies, Monoclonal, Disease Models, Animal, Fibrinolysin, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Neutralization Tests, Skin, Tissue Plasminogen Activator, Urokinase-Type Plasminogen Activator, Wound Healing, Wounds and Injuries",

author = "Annika J{\"o}gi and Birgitte R{\o}n{\o} and Lund, {Ida K} and Nielsen, {Boye S} and Michael Ploug and Gunilla H{\o}yer-Hansen and John R{\o}mer and Lund, {Leif R}",

year = "2010",

month = sep,

day = "1",

doi = "10.1371/journal.pone.0012746",

language = "English",

volume = "5",

pages = "e12746",

journal = "PLoS ONE",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "9",

}

RIS

TY - JOUR

T1 - Neutralisation of uPA with a monoclonal antibody reduces plasmin formation and delays skin wound healing in tPA-deficient mice

AU - Jögi, Annika

AU - Rønø, Birgitte

AU - Lund, Ida K

AU - Nielsen, Boye S

AU - Ploug, Michael

AU - Høyer-Hansen, Gunilla

AU - Rømer, John

AU - Lund, Leif R

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Proteolytic degradation by plasmin and metalloproteinases is essential for epidermal regeneration in skin wound healing. Plasminogen deficient mice have severely delayed wound closure as have mice simultaneously lacking the two plasminogen activators, urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA). In contrast, individual genetic deficiencies in either uPA or tPA lead to wound healing kinetics with no or only slightly delayed closure of skin wounds.

AB - Proteolytic degradation by plasmin and metalloproteinases is essential for epidermal regeneration in skin wound healing. Plasminogen deficient mice have severely delayed wound closure as have mice simultaneously lacking the two plasminogen activators, urokinase-type plasminogen activator (uPA) and tissue-type plasminogen activator (tPA). In contrast, individual genetic deficiencies in either uPA or tPA lead to wound healing kinetics with no or only slightly delayed closure of skin wounds.

KW - Animals

KW - Antibodies, Monoclonal

KW - Disease Models, Animal

KW - Fibrinolysin

KW - Humans

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Neutralization Tests

KW - Skin

KW - Tissue Plasminogen Activator

KW - Urokinase-Type Plasminogen Activator

KW - Wound Healing

KW - Wounds and Injuries

U2 - 10.1371/journal.pone.0012746

DO - 10.1371/journal.pone.0012746

M3 - Journal article

C2 - 20856796

VL - 5

SP - e12746

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 9

ER -

ID: 33752700