TY - JOUR

T1 - Neuromedin U Does Not Act as a Decretin in Rats

AU - Kuhre, Rune Ehrenreich

AU - Christiansen, Charlotte Bayer

AU - Ghiasi, Seyed Mojtaba

AU - Gabe, Maria Buur Nordskov

AU - Skat-Rørdam, Patricia Almine

AU - Modvig, Ida Marie

AU - Mandrup-Poulsen, Thomas

AU - Albrechtsen, Reidar

AU - Rosenkilde, Mette Marie

AU - Hartmann, Bolette

AU - Albrechtsen, Nicolai Jacob Wewer

AU - Holst, Jens Juul

PY - 2019

Y1 - 2019

N2 - Studies on isolated pancreatic islets suggest that neuromedin U (NMU), a brain and gastrointestinal peptide, acts as a decretin hormone, inhibiting glucose-stimulated insulin secretion. We investigated whether this effect could be reproduced in vivo and in isolated perfused rat pancreas. Unlike the incretin hormone, glucagon-like peptide 1 (GLP-1), intravenous NMU administration had no effects on blood glucose and plasma insulin and glucagon in vivo. Moreover, NMU neither changed insulin, glucagon, or somatostatin secretion from isolated perfused rat pancreas, nor affected GLP-1-stimulated insulin and somatostatin secretion. For NMU to act as a decretin hormone, its secretion should increase following glucose ingestion; however, glucose did not affect NMU secretion from isolated perfused rat small intestine, which contained extractable NMU. Furthermore, the two NMU receptors were not detected in endocrine rat or human pancreas. We conclude that NMU does not act as a decretin hormone in rats.

AB - Studies on isolated pancreatic islets suggest that neuromedin U (NMU), a brain and gastrointestinal peptide, acts as a decretin hormone, inhibiting glucose-stimulated insulin secretion. We investigated whether this effect could be reproduced in vivo and in isolated perfused rat pancreas. Unlike the incretin hormone, glucagon-like peptide 1 (GLP-1), intravenous NMU administration had no effects on blood glucose and plasma insulin and glucagon in vivo. Moreover, NMU neither changed insulin, glucagon, or somatostatin secretion from isolated perfused rat pancreas, nor affected GLP-1-stimulated insulin and somatostatin secretion. For NMU to act as a decretin hormone, its secretion should increase following glucose ingestion; however, glucose did not affect NMU secretion from isolated perfused rat small intestine, which contained extractable NMU. Furthermore, the two NMU receptors were not detected in endocrine rat or human pancreas. We conclude that NMU does not act as a decretin hormone in rats.

KW - decretin

KW - glucagon-like peptide 1

KW - insulin secretion

KW - neuromedin U

KW - neuromedin U receptor 1 and 2

KW - type 2 diabetes

U2 - 10.1016/j.cmet.2018.10.008

DO - 10.1016/j.cmet.2018.10.008

M3 - Journal article

C2 - 30449683

AN - SCOPUS:85062064719

VL - 29

SP - 719-726.e1-e5

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 3

ER -